Chetan Chitnis joined Institut Pasteur in 2014 to set up the Malaria Parasite Biology & Vaccines Unit. His laboratory investigates how malaria parasites invade human erythrocytes and uses these findings to develop new intervention strategies such as malaria vaccines. Dr. Chitnis completed his PhD at the University of California, Berkeley, in 1990 and conducted postdoctoral research on malaria at the US National Institutes of Health. He returned to India in 1995 where he established a laboratory that combined fundamental and translational malaria research. Dr. Chitnis is a Fellow of the Indian National Science Academy and has been a Wellcome Trust Senior Research Fellow and a Howard Hughes International Research Scholar. He is a recipient of the Infosys Prize in Life Sciences and the Bhatnagar Award in Medical Science, two of India’s most prestigious life sciences awards.
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Plasmodium vivax Invasion Pathways into Human Reticulocytes
Erythrocyte invasion is a complex process involving multiple interactions between Plasmodium merozoites and host erythrocytes. Unlike P. falciparum, which can use multiple erythrocyte receptors for invasion and has merozoite proteins with overlapping and redundant […]
2022Human peroxiredoxin 6 is essential for malaria parasites and provides a host-based drug target., Cell Rep 2022 Jun; 39(11): 110923.
2020Phosphorylation-Dependent Assembly of a 14-3-3 Mediated Signaling Complex during Red Blood Cell Invasion by Plasmodium falciparum Merozoites., mBio 2020 08; 11(4): .
2015Phase I Clinical Trial of a Recombinant Blood Stage Vaccine Candidate for Plasmodium falciparum Malaria Based on MSP1 and EBA175, PLoS ONE 2015;10(4):e0117820.
2014The central role of cAMP in regulating Plasmodium falciparum merozoite invasion of human erythrocytes, PLoS Pathog. 2014 Dec;10(12):e1004520.
2013Role of calcineurin and actin dynamics in regulated secretion of microneme proteins in Plasmodium falciparum merozoites during erythrocyte invasion, Cell. Microbiol. 2014 Jan;16(1):50-63.
2013Calcium-dependent permeabilization of erythrocytes by a perforin-like protein during egress of malaria parasites, Nat Commun 2013;4:1736.
2012Characterization of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) and its role in microneme secretion during erythrocyte invasion, J. Biol. Chem. 2013 Jan;288(3):1590-602.
2011Targeting TLRs expands the antibody repertoire in response to a malaria vaccine, Sci Transl Med 2011 Jul;3(93):93ra69.