Publications
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2018Crystal structures of a pentameric ion channel gated by alkaline pH show a widely open pore and identify a cavity for modulation, Proc. Natl. Acad. Sci. U.S.A. 2018 04;115(17):E3959-E3968.
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2017Full mutational mapping of titratable residues helps to identify proton-sensors involved in the control of channel gating in the Gloeobacter violaceus pentameric ligand-gated ion channel, PLoS Biol. 2017 12;15(12):e2004470.
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2013Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels, EMBO J. 2013 Mar;32(5):728-41.
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2012A locally closed conformation of a bacterial pentameric proton-gated ion channel, Nat. Struct. Mol. Biol. 2012 May;19(6):642-9.
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2011X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel, Nature 2011 Jan;469(7330):428-31.
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2010One-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologue, Proc. Natl. Acad. Sci. U.S.A. 2010 Apr;107(14):6275-80.
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2009Atomic structure and dynamics of pentameric ligand-gated ion channels: new insight from bacterial homologues, J. Physiol. (Lond.) 2010 Feb;588(Pt 4):565-72.