Timeline

Anne Brelot

Group Leader

07 Jan 2025

publication

Neural-network model for characterizing stochastic dynamic variability of cellular particles

22 Jul 2022

publication

Tracking receptor motions at the plasma membrane reveals distinct effects of ligands on CCR5 dynamics depending on its dimerization status.

26 Jan 2022

publication

Low CCR5 expression protects HIV-specific CD4+ T cells of elite controllers from viral entry.

06 Dec 2018

publication

CCR5 structural plasticity shapes HIV-1 phenotypic properties

19 Jun 2018

publication

CCR5 Revisited: How Mechanisms of HIV Entry Govern AIDS Pathogenesis

08 May 2018

publication

CCR5 adopts three homodimeric conformations that control cell surface delivery

03 Jul 2015

project

Viral Pathogenesis Unit’s Project

11 May 2015

team

Dynamics of Host-Pathogen Interactions

22 May 2014

publication

Targeting spare CC chemokine receptor 5 (CCR5) as a principle to inhibit HIV-1 entry

21 May 2013

publication

HIV-1 exploits CCR5 conformational heterogeneity to escape inhibition by chemokines

12 Sep 2007

publication

Identification of a postendocytic sorting sequence in CCR5

01 Jun 2005

publication

On the dimerization of CCR5

22 Dec 2004

publication

Identification of the cytoplasmic domains of CXCR4 involved in Jak2 and STAT3 phosphorylation

18 Oct 2004

publication

The composition of the beta-2 adrenergic receptor oligomer affects its membrane trafficking after ligand-induced endocytosis

01 Oct 2001

publication

Antigenically distinct conformations of CXCR4

01 Jun 2001

publication

Cooperation of the V1/V2 and V3 domains of human immunodeficiency virus type 1 gp120 for interaction with the CXCR4 receptor

01 Jan 2001

publication

HIV-1 entry and how to block it

01 Jan 2001

publication

Determination of coreceptor usage of human immunodeficiency virus type 1 from patient plasma samples by using a recombinant phenotypic assay

01 Aug 2000

publication

Identification of residues of CXCR4 critical for human immunodeficiency virus coreceptor and chemokine receptor activities

01 Apr 1999

publication

Effect of mutations in the second extracellular loop of CXCR4 on its utilization by human and feline immunodeficiency viruses

01 Aug 1998

publication

The second extracellular loop of CXCR4 determines its function as a receptor for feline immunodeficiency virus

01 Aug 1998

publication

Determinants for sensitivity of human immunodeficiency virus coreceptor CXCR4 to the bicyclam AMD3100

01 Jul 1998

publication

The second extracellular loop of CXCR4 is involved in CD4-independent entry of human immunodeficiency virus type 2

15 Sep 1997

publication

HIV-1 gp120 induces an association between CD4 and the chemokine receptor CXCR4

20 Jun 1997

publication

Identification of a chemokine receptor encoded by human cytomegalovirus as a cofactor for HIV-1 entry

01 Jun 1997

publication

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Timeline

Neural-network model for characterizing stochastic dynamic variability of cellular particles

Tracking receptor motions at the plasma membrane reveals distinct effects of ligands on CCR5 dynamics depending on its dimerization status.

Low CCR5 expression protects HIV-specific CD4+ T cells of elite controllers from viral entry.

CCR5 structural plasticity shapes HIV-1 phenotypic properties

CCR5 Revisited: How Mechanisms of HIV Entry Govern AIDS Pathogenesis

CCR5 adopts three homodimeric conformations that control cell surface delivery

Viral Pathogenesis Unit’s Project

Dynamics of Host-Pathogen Interactions

Targeting spare CC chemokine receptor 5 (CCR5) as a principle to inhibit HIV-1 entry

HIV-1 exploits CCR5 conformational heterogeneity to escape inhibition by chemokines

Identification of a postendocytic sorting sequence in CCR5

On the dimerization of CCR5

Identification of the cytoplasmic domains of CXCR4 involved in Jak2 and STAT3 phosphorylation

The composition of the beta-2 adrenergic receptor oligomer affects its membrane trafficking after ligand-induced endocytosis

Antigenically distinct conformations of CXCR4

Cooperation of the V1/V2 and V3 domains of human immunodeficiency virus type 1 gp120 for interaction with the CXCR4 receptor

HIV-1 entry and how to block it

Determination of coreceptor usage of human immunodeficiency virus type 1 from patient plasma samples by using a recombinant phenotypic assay

Identification of residues of CXCR4 critical for human immunodeficiency virus coreceptor and chemokine receptor activities

Effect of mutations in the second extracellular loop of CXCR4 on its utilization by human and feline immunodeficiency viruses

The second extracellular loop of CXCR4 determines its function as a receptor for feline immunodeficiency virus

Determinants for sensitivity of human immunodeficiency virus coreceptor CXCR4 to the bicyclam AMD3100

The second extracellular loop of CXCR4 is involved in CD4-independent entry of human immunodeficiency virus type 2

HIV-1 gp120 induces an association between CD4 and the chemokine receptor CXCR4

Identification of a chemokine receptor encoded by human cytomegalovirus as a cofactor for HIV-1 entry

Role of the first and third extracellular domains of CXCR-4 in human immunodeficiency virus coreceptor activity