PTR 232-2019. Mechabiome. Computational imaging of the spatiotemporal distribution of forces in gut tissue: a study of the cross talk between cell mechanics, microbiome and infectious processes
Mechanical forces trigger many cellular functions and change the geometry and physical properties of a tissue. Very few studies look at the biomechanisms of invasion of microbes at tissue level. – In this project […]
Impact of tissue components on cell migration: adhesion strength, cell morpho-dynamics and intracellular biophysics parameters.
We aim to analyze the impact of substrates on Entamoeba histolytica mode of migration during colonic mucosa invasion using live imaging and quantitative image analysis. E. histolytica, the etiological agent of amoebiasis, is a […]
Impact of gut mechanical forces and 3D architecture on the intestine homeostasis during pathogen interaction and in cancer disease
The intestine, and in particular the colon, comprising a mucus blanket, an epithelial monolayer and the lamina propria rich in immune cells, is constantly subjected to shear stress (flow) and peristaltic motion (stretching), both […]
Imaging and mathematical modelling of cell morphology and motility
Elucidating the mechanisms underlying cell deformation and motility is a topic of major interest in cell biology, for they are strongly involved in cell development, immune responses, cancer and infectious diseases. This projects focuses on the […]
2021Bioimage Analysis and Cell Motility, Patterns, 2021.
2020E-cadherin focuses protrusion formation at the front of migrating cells by impeding actin flow, Nat Commun. 2020.
2020A Protocol to Quantify Cellular Morphodynamics: From Cell Labelling to Automatic Image Analysis, Eukaryome Impact on Human Intestine Homeostasis and Mucosal Immunology, 2020.
2019Tracking and line integration of diffuse cellular subdomains by mesh advection, IEEE EMBC 2019.
2019Fluid dynamics during bleb formation in migrating cells in vivo, PLoS One 2019.
2018Multiple variational image assimilation for accessible micro-elastography, J. Phys. Conf. Ser. 2018.
2017BioFlow: a non-invasive, image-based method to measure speed, pressure and forces inside living cells., Sci Rep 2017 08; 7(1): 9178.