After a BTS in Biotechnology (1996) at ENCPB – Paris, Agnes DUBOIS started her career as a Technician and went through different fields in several companies. First, working for an industrialist (EUROVANILLE-|1997-2001) she has successfully driven an innovative research project onto the Vanilla orchid. Moving then to an academic institute (CENTRE NATIONAL DE GENOTYPAGE|2001-2003), she was involved into the identification of Human disease genes and genetic variants. After a short incursion into the hospital world (HEGP|2003-2004), she worked for a start-up (MOLECULAR CYTOGENETICS LABS|2004-2006) onto the development and quality certification of Human pan genomic bio-chips.
Since she joined the Philip AVNER’s lab at the INSTITUT PASTEUR – Paris in 2006, she has been particularly captivated to understand early epigenetic mechanisms of regulation of X Chromosome Inactivation, providing her a strong proficiency into embryonic stem cells culture, chromatin and non-coding RNAs fields of expertise, and, allowing her to validate an Ingenieur CNAM – Paris qualification in 2010. Finally, in 2013, she contributed to the establishment of the Epigenomics, Proliferation and Cell Identity lab in which she holds her current position. Her main focus deals with the deciphering of Chromatin regulation at the locus of the stemness-related marker Nanog in embryonic stem cells.
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2024Molecular and epistatic interactions between pioneer transcription factors shape nucleosome dynamics and cell differentiation, 2024.
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2024Mitotic bookmarking redundancy by nuclear receptors in pluripotent cells., Nat Struct Mol Biol 2024 Jan; (): .
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2022A gene subset requires CTCF bookmarking during the fast post-mitotic reactivation of mouse ES cells., EMBO Rep 2022 Nov; (): e56075.
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2022H3K9 tri-methylation at Nanog times differentiation commitment and enables the acquisition of primitive endoderm fate., Development 2022 Sep; 149(17): .
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2022OCT4 activates a Suv39h1-repressive antisense lncRNA to couple histone H3 Lysine 9 methylation to pluripotency., Nucleic Acids Res 2022 07; 50(13): 7367-7379.
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2021The combined action of Esrrb and Nr5a2 is essential for murine naïve pluripotency., Development 2021 Aug; (): .
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2019CTCF confers local nucleosome resiliency after DNA replication and during mitosis, Elife 2019 Oct;8.
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2019The molecular logic of Nanog-induced self-renewal in mouse embryonic stem cells, Nat Commun 2019 03;10(1):1109.
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2019Transcription factor activity and nucleosome organization in mitosis., Genome Res 2019 02; 29(2): 250-260.
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2016Mitotic binding of Esrrb marks key regulatory regions of the pluripotency network, Nat. Cell Biol. 2016 Oct;.
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