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© Nicola Festuccia, Institut Pasteur
Mouse embryonic stem cells stained for Ki67 (red) and Esrrb (green)
Publication : EMBO reports

A gene subset requires CTCF bookmarking during the fast post-mitotic reactivation of mouse ES cells.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in EMBO reports - 04 Nov 2022

Chervova A, Festuccia N, Altamirano-Pacheco L, Dubois A, Navarro P,

Link to Pubmed [PMID] – 36330771

Link to DOI – 10.15252/embr.202256075

EMBO Rep 2022 Nov; (): e56075

Mitosis leads to global downregulation of transcription that then needs to be efficiently resumed. In somatic cells, this is mediated by a transient hyper-active state that first reactivates housekeeping and then cell identity genes. Here, we show that mouse embryonic stem cells, which display rapid cell cycles and spend little time in G1, also display accelerated reactivation dynamics. This uniquely fast global reactivation lacks specificity towards functional gene families, enabling the restoration of all regulatory functions before DNA replication. Genes displaying the fastest reactivation are bound by CTCF, a mitotic bookmarking transcription factor. In spite of this, the post-mitotic global burst is robust and largely insensitive to CTCF depletion. There are, however, around 350 genes that respond to CTCF depletion rapidly after mitotic exit. Remarkably, these are characterised by promoter-proximal mitotic bookmarking by CTCF. We propose that the structure of the cell cycle imposes distinct constrains to post-mitotic gene reactivation dynamics in different cell types, via mechanisms that are yet to be identified but that can be modulated by mitotic bookmarking factors.

https://pubmed.ncbi.nlm.nih.gov/36330771