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© Cédric Delevoye
Cellules infectÈes par Chlamydia trachomatis. Les bactÈries se dÈveloppent dans une vacuole (rouge), ‡ proximitÈ du noyau de la cellule-hÙte (bleu). Ce compartiment interagit de faÁon Ètroite avec ceux de la cellule hÙte. Marquage vert= localisation d'une protÈine de l'hÙte, Vamp8, exprimÈe par transfection. Les Chlamydia sont, selon les souches, responsables de maladies sexuellement transmises, de cÈcitÈs, d'infections pulmonaires et pourraient Ítre impliquÈes dans l'athÈrosclÈrose.
Scientific Fields
Diseases
Organisms
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Technique
Application Deadline
30
Jun 2022
2022-06-30 8:00:00 2022-06-30 18:00:00 Europe/Paris Postdoctoral and Engineer positions – Epigenetic-based therapies to fight infectious diseases Project and Consortium description Five positions (four postdoctoral and one engineer) are available to join an interdisciplinarity consortium, located in the Paris area, to study the interplay between epigenetic regulation and infectious diseases. Our […] "25-28 rue du Dr. Roux, 75015, Paris" Agathe Subtil agathe.subtil@pasteur.fr

Project and Consortium description

Five positions (four postdoctoral and one engineer) are available to join an interdisciplinarity consortium, located in the Paris area, to study the interplay between epigenetic regulation and infectious diseases. Our objective is to find new therapeutic approaches to fight infection using epigenetic drugs. Our consortium combines expertise in the biology and epigenetics of infection (5 teams), in proteomics (1 team) and in drug-design and medicinal chemistry of epigenetics (2 teams). The partners are internationally-oriented research structures, located at the Pasteur Institute (6 laboratories), University of Paris (1 laboratory) and University Paris Saclay (1 laboratory). The strengths of the consortium are: (1) a strong track-record showing that pathogens modulate host epigenetic mechanisms; (2) considerable resources generated by medicinal chemists; (3) in-depth expertise on seven biological models, from in vitro and in cellulo to in vivo models. The research environment includes state-of-the-art equipment and facilities for the project. Salaries are funded for at least two years and will be adjusted according to the experience of the candidate.

Requirements

We are seeking highly-qualified and motivated candidates, with a strong background in the epigenetics or proteomics. We also expect good leadership skills, good English language skills, and a commitment to team science.

Selection process

Starts December 2021 and will be continued until staffing (expected start dates from February to June 2022). To apply, please submit (i) a motivation letter, (ii) a full CV including a publication list, and (iii) the contact address of three referees. Please add the reference “Position TheraEpi” in your email header.

Recruiting laboratories

  1. The Cellular biology of microbial infection lab, CNRS, Institut Pasteur, which studies the interactions between the bacterium Chlamydia trachomatis and human epithelial cells.
    For a postdoc application, please contact Dr. A. Subtil (agathe.subtil@pasteur.fr)
  2. The Proteomics platform, Institut Pasteur, which has a strong expertise in advanced quantitative proteomics approaches and post-translational modifications.
    For a postdoc application, please contact Dr. M. Matondo (mariette.matondo@pasteur.fr)
  3. The Epigenetics and Cellular Microbiology lab, INRAE, Université Paris Saclay, which studies the interactions between the Gram-positive Listeria monocytogenes bacterium and mammalian cells.
    For a postdoc and an engineer application, please contact Dr. H. Bierne (helene.bierne@inrae.fr) and Dr. A. Pagliuso (alessandro.pagliuso@inrae.fr)
  4. The Epigenetics and Cell Fate lab, CNRS, Université de Paris, which studies the interactions between intracellular apicomplexan parasites and bovine leukocytes.
    For a postdoc application, please contact Pr. J. Weitzman (jonathan.weitzman@u-paris.fr)

 

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