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Scientific Fields
Diseases
Organisms
Applications
Technique
Date
03
Jul 2019
Time
11:00:00
25 Rue du Docteur Roux, Paris, France
Address
Room: Amphitheater Jaques Monod - Pasteur
Location
2019-07-03 11:00:00 2019-07-03 00:00:00 Europe/Paris Antigen Receptor Repertoires and Specificities at Single Cell Resolution Abstract The adaptive immune system requires an enormously diverse repertoire of antigen receptors (AgRs) on T and B cells. This diversity is generated by DNA rearrangement in each developing lymphocyte that combines randomly chosen gene segments and introduces […] 25 Rue du Docteur Roux, Paris, France Valentina Libri valentina.libri@pasteur.fr

About

Abstract

The adaptive immune system requires an enormously diverse repertoire of antigen receptors (AgRs) on T and B cells. This diversity is generated by DNA rearrangement in each developing lymphocyte that combines randomly chosen gene segments and introduces additional variability at the junctions between segments. The distinctiveness and diversity of AgRs mean that single-cell techniques are ideal to study antigen receptor repertoires. Furthermore, AgRs are heterodimeric proteins that comprise two independently encoded protein chains that both typically determine each receptor’s antigen specificity; single-cell measurements identify the paired receptor chains in each cell.
Single-cell AgR analysis allows us to infer clonal relationships between lymphocytes and connect this to their transcriptional state. I will discuss insights that have been gained using this approach and the potential for exciting future advances that will be made possible by methods also identify each receptor’s cognate antigen. I will introduce a new, large-scale dataset that maps TCR specificity with high throughput and resolution.

Location

Room: Amphitheater Jaques Monod - Pasteur
Address: 25 Rue du Docteur Roux, Paris, France