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SaMMBA seminar (Modélisation mathématique et statistique en Biologie) Infection & Epidemiology department : “Forecasting the spreading of diseases in the digital era ” with Nicola Perra

Department of Immunology seminar: Jak/STAT signals underlying innate lymphoid cell homeostasis and activation, Giuseppe Sciumè

© William Beaucardet

Reportage Laboratoire des Anticorps en Thérapie et Pathologie

Event

Antigen Receptor Repertoires and Specificities at Single Cell Resolution

Team: UTechS Single Cell Biomarkers

Department of: Immunology

Center: Center for Technological Resources and Research

Member: Valentina Libri

Member: Milena Hasan

Member: Bernd Jagla

Scientific Fields

Diseases

Organisms

Applications

Technique

Date

03

Jul 2019

Time

11:00:00

25 Rue du Docteur Roux, Paris, France

Address

2019-07-03 11:00:00 2019-07-03 00:00:00 Europe/Paris Antigen Receptor Repertoires and Specificities at Single Cell Resolution Abstract The adaptive immune system requires an enormously diverse repertoire of antigen receptors (AgRs) on T and B cells. This diversity is generated by DNA rearrangement in each developing lymphocyte that combines randomly chosen gene segments and introduces […] 25 Rue du Docteur Roux, Paris, France Valentina Libri valentina.libri@pasteur.fr

Speakers

Mike Stubbington

About

Abstract

The adaptive immune system requires an enormously diverse repertoire of antigen receptors (AgRs) on T and B cells. This diversity is generated by DNA rearrangement in each developing lymphocyte that combines randomly chosen gene segments and introduces additional variability at the junctions between segments. The distinctiveness and diversity of AgRs mean that single-cell techniques are ideal to study antigen receptor repertoires. Furthermore, AgRs are heterodimeric proteins that comprise two independently encoded protein chains that both typically determine each receptor’s antigen specificity; single-cell measurements identify the paired receptor chains in each cell.

Single-cell AgR analysis allows us to infer clonal relationships between lymphocytes and connect this to their transcriptional state. I will discuss insights that have been gained using this approach and the potential for exciting future advances that will be made possible by methods also identify each receptor’s cognate antigen. I will introduce a new, large-scale dataset that maps TCR specificity with high throughput and resolution.

Location

Address: 25 Rue du Docteur Roux, Paris, France

Published on: 18 Mar 2019 • Modified on: 10 Mar 2021

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