Timeline

Laleh Majlessi

Associate Professor

02 Apr 2024

publication

A measles-vectored vaccine candidate expressing prefusion-stabilized SARS-CoV-2 spike protein brought to phase I/II clinical trials: candidate selection in a preclinical murine model.

07 Sep 2023

publication

Full eradication of pre-clinical human papilloma virus-induced tumors by a lentiviral vaccine.

18 Apr 2023

publication

Mice Humanized for MHC and hACE2 with High Permissiveness to SARS-CoV-2 Omicron Replication.

01 Jan 2023

publication

Sec61 blockade therapy overrides resistance to proteasome inhibitors and immunomodulatory drugs in multiple myeloma.

01 Jan 2023

publication

Preclinical proof of concept of a tetravalent lentiviral T-cell vaccine against dengue viruses.

21 Dec 2022

publication

Full-Lung Prophylaxis against SARS-CoV-2 by One-Shot or Booster Intranasal Lentiviral Vaccination in Syrian Golden Hamsters

14 Sep 2022

publication

A lentiviral vector expressing a dendritic cell-targeting multimer induces mucosal anti-mycobacterial CD4+ T-cell immunity.

26 Jul 2022

publication

A lentiviral vector encoding fusion of light invariant chain and mycobacterial antigens induces protective CD4+ T cell immunity.

27 Apr 2022

publication

An intranasal lentiviral booster reinforces the waning mRNA vaccine-induced SARS-CoV-2 immunity that it targets to lung mucosa.

07 Dec 2021

publication

Brain cross-protection against SARS-CoV-2 variants by a lentiviral vaccine in new transgenic mice.

29 Jul 2021

team

Institut Pasteur-TheraVectys Joint Laboratory

09 Apr 2021

event

Seminar DPT Microbiology “Intranasal Vaccination with a Lentiviral Vector Fully Protects Lungs and Brain against SARS-CoV-2”, Laleh Majlessi

06 Apr 2021

project

Modeling SARS-CoV-2 infection and immune responses in humanized mouse models

01 Mar 2019

publication

Intrinsic Antibacterial Activity of Nanoparticles Made of β-Cyclodextrins Potentiates Their Effect as Drug Nanocarriers Against Tuberculosis

11 Jul 2018

publication

Unexpected genomic and phenotypic diversity of Mycobacterium africanum Lineage 5 affects drug resistance, protein secretion and immunogenicity

18 Jun 2018

publication

RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection

24 Apr 2018

publication

Multiplexed Quantitation of Intraphagocyte Mycobacterium tuberculosis Secreted Protein Effectors

17 Jan 2018

publication

Identification of genes required for Mycobacterium abscessus growth in vivo with a prominent role of the ESX-4 locus

28 Aug 2017

publication

Un nouveau concept pour améliorer le vaccin antituberculeux

14 Mar 2017

publication

Recombinant BCG Expressing ESX-1 of Mycobacterium marinum Combines Low Virulence with Cytosolic Immune Signaling and Improved TB Protection

01 Feb 2017

publication

Colonization with Helicobacter is concomitant with modified gut microbiota and drastic failure of the immune control of Mycobacterium tuberculosis

01 Nov 2016

publication

The distinct fate of smooth and rough Mycobacterium abscessus variants inside macrophages

26 Sep 2016

publication

ESX secretion systems: mycobacterial evolution to counter host immunity

28 Jul 2016

publication

CD4+ T Cells Recognizing PE/PPE Antigens Directly or via Cross Reactivity Are Protective against Pulmonary Mycobacterium tuberculosis Infection

31 May 2016

publication

Perspectives on mycobacterial vacuole-to-cytosol translocation: the importance of cytosolic access

28 Apr 2016

publication

A unique PE_PGRS protein inhibiting host cell cytosolic defenses and sustaining full virulence of Mycobacterium marinum in multiple hosts

27 Jan 2016

publication

pks5-recombination-mediated surface remodelling in Mycobacterium tuberculosis emergence

02 Dec 2015

event

EMBO Conference Tuberculosis 2016

25 Nov 2015

publication

Revisiting the role of phospholipases C in virulence and the lifecycle of Mycobacterium tuberculosis

10 Jun 2015

publication

Mycobacterium tuberculosis Meets the Cytosol: The Role of cGAS in Anti-mycobacterial Immunity

11 May 2015

team

Integrated Mycobacterial Pathogenomics

01 Mar 2015

publication

Release of mycobacterial antigens

13 Feb 2015

publication

ESX/type VII secretion systems of mycobacteria: Insights into evolution, pathogenicity and protection

06 Feb 2015

publication

Cytosolic access of Mycobacterium tuberculosis: critical impact of phagosomal acidification control and demonstration of occurrence in vivo

06 Jan 2013

publication

Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis

19 Apr 2012

publication

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Timeline

A measles-vectored vaccine candidate expressing prefusion-stabilized SARS-CoV-2 spike protein brought to phase I/II clinical trials: candidate selection in a preclinical murine model.

Full eradication of pre-clinical human papilloma virus-induced tumors by a lentiviral vaccine.

Mice Humanized for MHC and hACE2 with High Permissiveness to SARS-CoV-2 Omicron Replication.

Sec61 blockade therapy overrides resistance to proteasome inhibitors and immunomodulatory drugs in multiple myeloma.

Preclinical proof of concept of a tetravalent lentiviral T-cell vaccine against dengue viruses.

Full-Lung Prophylaxis against SARS-CoV-2 by One-Shot or Booster Intranasal Lentiviral Vaccination in Syrian Golden Hamsters

A lentiviral vector expressing a dendritic cell-targeting multimer induces mucosal anti-mycobacterial CD4+ T-cell immunity.

A lentiviral vector encoding fusion of light invariant chain and mycobacterial antigens induces protective CD4+ T cell immunity.

An intranasal lentiviral booster reinforces the waning mRNA vaccine-induced SARS-CoV-2 immunity that it targets to lung mucosa.

Brain cross-protection against SARS-CoV-2 variants by a lentiviral vaccine in new transgenic mice.

Institut Pasteur-TheraVectys Joint Laboratory

Seminar DPT Microbiology “Intranasal Vaccination with a Lentiviral Vector Fully Protects Lungs and Brain against SARS-CoV-2”, Laleh Majlessi

Modeling SARS-CoV-2 infection and immune responses in humanized mouse models

Intrinsic Antibacterial Activity of Nanoparticles Made of β-Cyclodextrins Potentiates Their Effect as Drug Nanocarriers Against Tuberculosis

Unexpected genomic and phenotypic diversity of Mycobacterium africanum Lineage 5 affects drug resistance, protein secretion and immunogenicity

RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection

Multiplexed Quantitation of Intraphagocyte Mycobacterium tuberculosis Secreted Protein Effectors

Identification of genes required for Mycobacterium abscessus growth in vivo with a prominent role of the ESX-4 locus

Un nouveau concept pour améliorer le vaccin antituberculeux

Recombinant BCG Expressing ESX-1 of Mycobacterium marinum Combines Low Virulence with Cytosolic Immune Signaling and Improved TB Protection

Colonization with Helicobacter is concomitant with modified gut microbiota and drastic failure of the immune control of Mycobacterium tuberculosis

The distinct fate of smooth and rough Mycobacterium abscessus variants inside macrophages

ESX secretion systems: mycobacterial evolution to counter host immunity

CD4+ T Cells Recognizing PE/PPE Antigens Directly or via Cross Reactivity Are Protective against Pulmonary Mycobacterium tuberculosis Infection

Perspectives on mycobacterial vacuole-to-cytosol translocation: the importance of cytosolic access

A unique PE_PGRS protein inhibiting host cell cytosolic defenses and sustaining full virulence of Mycobacterium marinum in multiple hosts

pks5-recombination-mediated surface remodelling in Mycobacterium tuberculosis emergence

EMBO Conference Tuberculosis 2016

Revisiting the role of phospholipases C in virulence and the lifecycle of Mycobacterium tuberculosis

Mycobacterium tuberculosis Meets the Cytosol: The Role of cGAS in Anti-mycobacterial Immunity

Integrated Mycobacterial Pathogenomics

Release of mycobacterial antigens

ESX/type VII secretion systems of mycobacteria: Insights into evolution, pathogenicity and protection

Cytosolic access of Mycobacterium tuberculosis: critical impact of phagosomal acidification control and demonstration of occurrence in vivo

Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis

Strong immunogenicity and cross-reactivity of Mycobacterium tuberculosis ESX-5 type VII secretion: encoded PE-PPE proteins predicts vaccine potential