Ligne de temps
Eric Prina
Chercheur(euse) Permanent(e)
10 févr. 2022
22 juin 2020
publication
Dynamic imaging reveals surface exposure of virulent Leishmania amastigotes during pyroptosis of infected macrophages.
Lire plus20 mai 2020
publication
Infectivity and Drug Susceptibility Profiling of Different Leishmania-Host Cell Combinations.
Lire plus20 févr. 2020
publication
SILAC-based quantitative proteomics reveals pleiotropic, phenotypic modulation in primary murine macrophages infected with the protozoan pathogen Leishmania donovani.
Lire plus11 févr. 2020
publication
Targeting Macrophage Histone H3 Modification as a Leishmania Strategy to Dampen the NF-κB/NLRP3-Mediated Inflammatory Response.
Lire plus01 janv. 2020
publication
Leishmania amazonensis Subverts the Transcription Factor Landscape in Dendritic Cells to Avoid Inflammasome Activation and Stall Maturation.
Lire plus24 janv. 2019
publication
Discovery of novel hit compounds with broad activity against visceral and cutaneous Leishmania species by comparative phenotypic screening.
Lire plus16 janv. 2019
project
International Mixed Unit ‘Inflammation and Leishmania infection’ (IMU-InflaLeish): Exploiting host-pathogen interaction for the discovery of novel anti-microbial drug targets and drug candidates.
Lire plus16 janv. 2019
project
“Modelling and functional analysis of clonal Evolution in Leishmania – possible role of non-coding RNAs and RNA modification”
Lire plus23 déc. 2016
publication
Effect of clinically approved HDAC inhibitors on Plasmodium, Leishmania and Schistosoma parasite growth
Lire plus22 sept. 2016
publication
Exploration of the imidazo[1,2-b]pyridazine scaffold as a protein kinase inhibitor
Lire plus01 mai 2016
publication
From Drug Screening to Target Deconvolution: a Target-Based Drug Discovery Pipeline Using Leishmania Casein Kinase 1 Isoform 2 To Identify Compounds with Antileishmanial Activity.
Lire plus08 sept. 2015
project
ANR Patho-Methylome – The role of lysine methylation in host-pathogen interactions
Lire plus07 sept. 2015
07 sept. 2015
project
FP7 Targeting the Leishmania kinome for the development of novel anti-parasitic strategies (LeishDrug)
Lire plus07 sept. 2015
project
ANR TransLeish – Discovery of druggable protein kinases in the protozoan parasite Leishmania donovani using hit compounds identified by phenotypic screening
Lire plus07 sept. 2015
project
PTR 539 – A multilevel systems approach to elucidate the host-Leishmania interactome and to identify host targets for anti-leishmanial drug discovery
Lire plus07 sept. 2015
project
PTR 496 – Investigating the reciprocal relationship between macrophage inflammasome activity and intracellular Leishmania infection
Lire plus11 mai 2015
31 oct. 2014
publication
Simultaneous multi-parametric analysis of Leishmania and of its hosting mammal cells: A high content imaging-based method enabling sound drug discovery process
Lire plus01 juil. 2014
publication
Probing druggability and biological function of essential proteins in Leishmania combining facilitated null mutant and plasmid shuffle analyses.
Lire plus01 janv. 2014
publication
Pharmacological assessment defines Leishmania donovani casein kinase 1 as a drug target and reveals important functions in parasite viability and intracellular infection.
Lire plus09 août 2012
publication