Ligne de temps

Eric Prina
Chercheur(euse) Permanent(e)
22 Jun 2020
publication

Dynamic imaging reveals surface exposure of virulent Leishmania amastigotes during pyroptosis of infected macrophages.

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09 Jun 2020
publication

Leishmania amazonensis Subverts the Transcription Factor Landscape in Dendritic Cells to Avoid Inflammasome Activation and Stall Maturation

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20 May 2020
publication

Infectivity and Drug Susceptibility Profiling of Different Leishmania-Host Cell Combinations.

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20 Feb 2020
publication

SILAC-based quantitative proteomics reveals pleiotropic, phenotypic modulation in primary murine macrophages infected with the protozoan pathogen Leishmania donovani.

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11 Feb 2020
publication

Targeting Macrophage Histone H3 Modification as a Leishmania Strategy to Dampen the NF-κB/NLRP3-Mediated Inflammatory Response.

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24 Jan 2019
publication

Discovery of novel hit compounds with broad activity against visceral and cutaneous Leishmania species by comparative phenotypic screening

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16 Jan 2019
project

International Mixed Unit ‘Inflammation and Leishmania infection’ (IMU-InflaLeish): Exploiting host-pathogen interaction for the discovery of novel anti-microbial drug targets and drug candidates.

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16 Jan 2019
project

“Modelling and functional analysis of clonal Evolution in Leishmania – possible role of non-coding RNAs and RNA modification”

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08 Jun 2017
publication

The enemy within: Targeting host-parasite interaction for antileishmanial drug discovery

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23 Dec 2016
publication

Effect of clinically approved HDAC inhibitors on Plasmodium, Leishmania and Schistosoma parasite growth

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22 Sep 2016
publication

Exploration of the imidazo[1,2-b]pyridazine scaffold as a protein kinase inhibitor

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22 Apr 2016
publication

From Drug Screening to Target Deconvolution: a Target-Based Drug Discovery Pipeline Using Leishmania Casein Kinase 1 Isoform 2 To Identify Compounds with Antileishmanial Activity.

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08 Sep 2015
project

ANR Patho-Methylome – The role of lysine methylation in host-pathogen interactions

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07 Sep 2015
project

FP7 Anti-Parasitic Drug Discovery in Epigenetics (A-ParaDDisE)

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07 Sep 2015
project

FP7 Targeting the Leishmania kinome for the development of novel anti-parasitic strategies (LeishDrug)

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07 Sep 2015
project

ANR TransLeish – Discovery of druggable protein kinases in the protozoan parasite Leishmania donovani using hit compounds identified by phenotypic screening

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07 Sep 2015
project

PTR 539 – A multilevel systems approach to elucidate the host-Leishmania interactome and to identify host targets for anti-leishmanial drug discovery

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07 Sep 2015
project

PTR 496 – Investigating the reciprocal relationship between macrophage inflammasome activity and intracellular Leishmania infection

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11 May 2015
team

Parasitologie moléculaire et Signalisation

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31 Oct 2014
publication

Simultaneous multi-parametric analysis of Leishmania and of its hosting mammal cells: A high content imaging-based method enabling sound drug discovery process

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03 Jun 2014
publication

Probing druggability and biological function of essential proteins in Leishmania combining facilitated null mutant and plasmid shuffle analyses

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23 Dec 2013
publication

Pharmacological assessment defines Leishmania donovani casein kinase 1 as a drug target and reveals important functions in parasite viability and intracellular infection

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09 Aug 2012
publication

The crystal structure of the MAP kinase LmaMPK10 from Leishmania major reveals parasite-specific features and regulatory mechanisms

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