Ligne de temps

Lluis Quintana-Murci
Responsable de Structure
04 Jan 2021
publication

Gut microbiome stability and dynamics in healthy donors and patients with non-gastrointestinal cancers.

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29 Sep 2020
news

Detection of autoantibodies against type I IFNs in patients as a cause of life-threatening COVID-19

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24 Sep 2020
publication

Auto-antibodies against type I IFNs in patients with life-threatening COVID-19.

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30 Jul 2020
publication

Population variation in miRNAs and isomiRs and their impact on human immunity to infection.

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29 Jul 2020
event

Milieu Intérieur Annual Meeting 2020

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26 Jun 2020
publication

Recent common origin, reduced population size, and marked admixture have shaped European Roma genomes.

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19 Jun 2020
publication

A trans-eQTL network regulates osteoclast multinucleation and bone mass.

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16 Jun 2020
publication

Common homozygosity for predicted loss-of-function variants reveals both redundant and advantageous effects of dispensable human genes.

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11 Jun 2020
publication

A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection.

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01 Jun 2020
publication

Evolutionary and population (epi)genetics of immunity to infection.

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05 May 2020
publication

Associations between consumption of dietary fibers and the risk of cardiovascular diseases, cancers, type 2 diabetes, and mortality in the prospective NutriNet-Santé cohort.

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10 Apr 2020
team

Group : Milieu Intérieur

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27 Mar 2020
publication

Genetic susceptibility to severe childhood asthma and rhinovirus-C maintained by balancing selection in humans for 150 000 years.

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13 Mar 2020
publication

Quantitative genetic analysis deciphers the impact of cis and trans regulation on cell-to-cell variability in protein expression levels

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02 Jan 2020
publication

Functional consequences of archaic introgression and their impact on fitness

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05 Dec 2019
publication

Human SNORA31 variations impair cortical neuron-intrinsic immunity to HSV-1 and underlie herpes simplex encephalitis

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29 Nov 2019
news

Lluis Quintana-Murci, lauréat 2019 du Prix de la Fondation Allianz-Institut de France

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05 Nov 2019
event

Population and systems immunology symposium

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31 Oct 2019
publication

Associations of autozygosity with a broad range of human phenotypes

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01 Oct 2019
news

DISTINCTION: Lluis Quintana-Murci nommé professeur au Collège de France

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13 Sep 2019
news

distinction Lluis Quintana-Murci lauréat du Prix Duquesne 2019

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13 Sep 2019
publication

A comprehensive assessment of demographic, environmental, and host genetic associations with gut microbiome diversity in healthy individuals.

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09 Aug 2019
publication

Counting Oceanians of Non-European, Non-Asian Descent (ONENA) in the South Pacific to Make Them Count in Global Health

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08 Aug 2019
publication

Genomic Evidence for Local Adaptation of Hunter-Gatherers to the African Rainforest

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29 Jul 2019
publication

Natural selection contributed to immunological differences between hunter-gatherers and agriculturalists

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18 Jun 2019
publication

A Call for Blood-In Human Immunology

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30 May 2019
publication

Impact and Evolutionary Determinants of Neanderthal Introgression on Transcriptional and Post-Transcriptional Regulation

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08 May 2019
publication

Homozygosity for P1104A underlies tuberculosis in about 1% of patients in a cohort of European ancestry

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01 May 2019
publication

Associations between usual diet and gut microbiota composition: results from the Milieu Intérieur cross-sectional study

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11 Apr 2019
publication

Defining the genetic and evolutionary architecture of alternative splicing in response to infection

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27 Mar 2019
publication

Diversity of Killer Cell Ig-Like Receptor, HLA Class I, and Their Interactions in Seven Populations of Sub-Saharan Africans

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21 Mar 2019
publication

Human Immunology through the Lens of Evolutionary Genetics

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28 Feb 2019
publication

Recent Adaptive Acquisition by African Rainforest Hunter-Gatherers of the Late Pleistocene Sickle-Cell Mutation Suggests Past Differences in Malaria Exposure

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11 Feb 2019
team

Génomique évolutive, modélisation et santé

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27 Dec 2018
publication

Blacklisting variants common in private cohorts but not in public databases optimizes human exome analysis

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21 Dec 2018
publication

Human IFN-γ immunity to mycobacteria is governed by both IL-12 and IL-23

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21 Dec 2018
publication

Tuberculosis and impaired IL-23-dependent IFN-γ immunity in humans homozygous for a common missense variant

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18 Dec 2018
publication

Exploring the genetic basis of human population differences in DNA methylation and their causal impact on immune gene regulation

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01 Dec 2018
publication

Editorial overview: The history, geography and adaptation of human genes: A tribute to L. Luca Cavalli-Sforza

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09 Nov 2018
publication

Polygenic adaptation and convergent evolution on growth and cardiac genetic pathways in African and Asian rainforest hunter-gatherers

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16 Oct 2018
publication

Systematic evaluation of DNA methylation age estimation with common preprocessing methods and the Infinium MethylationEPIC BeadChip array

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05 Sep 2018
publication

Human thymopoiesis is influenced by a common genetic variant within the TCRA-TCRD locus.

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10 Aug 2018
publication

The demographic and adaptive history of central African hunter-gatherers and farmers

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01 Aug 2018
publication

Host and viral genetic diversity can help explain mortality during the 1918-21 influenza pandemic in the Pacific region

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27 Jul 2018
publication

Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines.

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01 Jun 2018
publication

Publisher Correction: Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors.

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14 Mar 2018
publication

IRF4 haploinsufficiency in a family with Whipple’s disease

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12 Mar 2018
publication

The demographic history and mutational load of African hunter-gatherers and farmers

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01 Mar 2018
publication

Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors.

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27 Dec 2017
publication

Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges

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20 Dec 2017
publication

miR-222 isoforms are differentially regulated by type-I interferon

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09 Nov 2017
publication

The Genetic Legacy of the Indian Ocean Slave Trade: Recent Admixture and Post-admixture Selection in the Makranis of Pakistan

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13 Jul 2017
publication

Deconvolution of the Response to Bacillus Calmette-Guérin Reveals NF-κB-Induced Cytokines As Autocrine Mediators of Innate Immunity

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22 May 2017
publication

Trends in DNA Methylation with Age Replicate Across Diverse Human Populations

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28 Mar 2017
publication

Living in an adaptive world: Genomic dissection of the genus Homo and its immune response

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13 Mar 2017
publication

Aboriginal Australian mitochondrial genome variation – an increased understanding of population antiquity and diversity

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03 Jan 2017
publication

[Innate immunity and human diseases: from archaic introgression to natural selection]

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01 Dec 2016
publication

Mitochondrial DNA diversity of present-day Aboriginal Australians and implications for human evolution in Oceania

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07 Nov 2016
publication

Understanding rare and common diseases in the context of human evolution

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20 Oct 2016
publication

Genetic Adaptation and Neandertal Admixture Shaped the Immune System of Human Populations

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17 Oct 2016
publication

Might Interspecific Interactions between Pathogens Drive Host Evolution? The Case of Plasmodium Species and Duffy-Negativity in Human Populations

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19 Sep 2016
publication

Dual T cell- and B cell-intrinsic deficiency in humans with biallelic RLTPR mutations

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26 Aug 2016
news

New publication for Milieu Intérieur

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25 Aug 2016
publication

Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses

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11 Aug 2016
publication

An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease

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13 May 2016
publication

Genetic and epigenetic variation of human populations: An adaptive tale

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01 Feb 2016
publication

The mutation significance cutoff: gene-level thresholds for variant predictions

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29 Jan 2016
event

Milieu Intérieur Scientific Advisory Board

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01 Jan 2016
publication

Genomic Signatures of Selective Pressures and Introgression from Archaic Hominins at Human Innate Immunity Genes

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30 Nov 2015
publication

The epigenomic landscape of African rainforest hunter-gatherers and farmers

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30 Oct 2015
publication

Antiquity and diversity of aboriginal Australian Y-chromosomes

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19 Oct 2015
publication

The human gene damage index as a gene-level approach to prioritizing exome variants

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08 Oct 2015
publication

Genetic Diversity in the Lesser Antilles and Its Implications for the Settlement of the Caribbean Basin

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16 Sep 2015
publication

Origins, admixture and founder lineages in European Roma

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10 Sep 2015
project

ERC-2011-StG EVOIMMUNOPOP

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10 Sep 2015
project

The footprints of natural selection in the human genome

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10 Sep 2015
project

Evolutionary genomics of innate immunity in humans

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10 Sep 2015
project

Genetics of gene expression in immunity to infection

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10 Sep 2015
project

Human lifestyle and genetic and epigenetic variation

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10 Sep 2015
event

Milieu Intérieur speed-dating symposium

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10 Sep 2015
event

Milieu Intérieur seminar

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10 Sep 2015
event

Milieu Intérieur seminar

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04 Aug 2015
program_project

The Healthy Human Global Project

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11 Jul 2015
program_project

Milieu Intérieur [LabEx]

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21 May 2015
publication

Genome-wide signatures of male-mediated migration shaping the Indian gene pool

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11 May 2015
team

Génétique Évolutive Humaine

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01 Apr 2015
publication

The Milieu Intérieur study – an integrative approach for study of human immunological variance.

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20 Mar 2015
publication

bacterial infection drives the expression dynamics of microRNAs and their isomiRs

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14 Jan 2015
publication

Y-chromosome descent clusters and male differential reproductive success: young lineage expansions dominate Asian pastoral nomadic populations

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07 Jan 2015
publication

Automated flow cytometric analysis across large numbers of samples and cell types

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20 Dec 2014
project

LISTERIAGEN (ANR)

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17 Sep 2014
publication

Editorial Overview: immunogenetics and transplantation: bringing evolution and genomics to human immunology

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03 Sep 2014
publication

Preserving immune diversity through ancient inheritance and admixture

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24 Aug 2014
publication

The Red Queen’s long race: human adaptation to pathogen pressure

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18 Aug 2014
publication

Adaptive, convergent origins of the pygmy phenotype in African rainforest hunter-gatherers

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17 Jul 2014
publication

Genetic diversity in Puerto Rico and its implications for the peopling of the Island and the West Indies

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29 Apr 2014
publication

Geographic population structure analysis of worldwide human populations infers their biogeographical origins

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03 Apr 2014
publication

HGCS: an online tool for prioritizing disease-causing gene variants by biological distance

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01 Apr 2014
publication

Exploring the occurrence of classic selective sweeps in humans using whole-genome sequencing data sets

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20 Mar 2014
publication

Functional analysis via standardized whole-blood stimulation systems defines the boundaries of a healthy immune response to complex stimuli

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04 Feb 2014
publication

Mitochondrial genome sequencing in Mesolithic North East Europe Unearths a new sub-clade within the broadly distributed human haplogroup C1

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30 Jan 2014
publication

A genomic portrait of the genetic architecture and regulatory impact of microRNA expression in response to infection

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25 Jan 2014
publication

From cheek swabs to consensus sequences: an A to Z protocol for high-throughput DNA sequencing of complete human mitochondrial genomes

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11 Oct 2013
publication

Ancient DNA reveals key stages in the formation of central European mitochondrial genetic diversity

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03 Oct 2013
publication

Immunology taught by human genetics

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24 Sep 2013
publication

Human genetic data reveal contrasting demographic patterns between sedentary and nomadic populations that predate the emergence of farming

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01 Aug 2013
publication

Sequencing Y chromosomes resolves discrepancy in time to common ancestor of males versus females

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12 Jul 2013
publication

Different selective pressures shape the evolution of Toll-like receptors in human and African great ape populations

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29 May 2013
publication

Uniparental markers in Italy reveal a sex-biased genetic structure and different historical strata

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26 Apr 2013
publication

Evidence for polygenic adaptation to pathogens in the human genome

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11 Apr 2013
publication

Ribosomal protein SA haploinsufficiency in humans with isolated congenital asplenia

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01 Apr 2013
publication

The genetics of innate immunity sensors and human disease

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18 Mar 2013
publication

The human gene connectome as a map of short cuts for morbid allele discovery

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08 Mar 2013
publication

Population genetic tools for dissecting innate immunity in humans

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14 Feb 2013
publication

Ancient DNA reveals prehistoric gene-flow from siberia in the complex human population history of North East Europe

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30 Jan 2013
publication

Y-chromosome and mtDNA genetics reveal significant contrasts in affinities of modern Middle Eastern populations with European and African populations

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21 Jan 2013
publication

The impact of natural selection on health and disease: uses of the population genetics approach in humans

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07 Jan 2013
publication

Sociocultural behavior, sex-biased admixture, and effective population sizes in Central African Pygmies and non-Pygmies

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01 Jan 2013
publication

The GenoChip: a new tool for genetic anthropology

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01 Jan 2013
publication

Neolithic mitochondrial haplogroup H genomes and the genetic origins of Europeans

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01 Jan 2013
publication

A genome-wide perspective of human diversity and its implications in infectious disease

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21 Dec 2012
publication

[Population genetics and human immunity: the interferon paradigm]

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28 Nov 2012
publication

Population differentiation of southern Indian male lineages correlates with agricultural expansions predating the caste system

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12 Sep 2012
publication

Contemporary paternal genetic landscape of Polish and German populations: from early medieval Slavic expansion to post-World War II resettlements

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25 Jul 2012
publication

Y-chromosome analysis in individuals bearing the Basarab name of the first dynasty of Wallachian kings

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28 Jun 2012
publication

The evolutionary landscape of cytosolic microbial sensors in humans

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14 May 2012
publication

Y-chromosome analysis reveals genetic divergence and new founding native lineages in Athapaskan- and Eskimoan-speaking populations

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01 May 2012
publication

Clan, language, and migration history has shaped genetic diversity in Haida and Tlingit populations from Southeast Alaska

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28 Mar 2012
publication

Afghanistan’s ethnic groups share a Y-chromosomal heritage structured by historical events

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12 Mar 2012
publication

Evidence of pre-Roman tribal genetic structure in Basques from uniparentally inherited markers

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23 Feb 2012
publication

The Basque paradigm: genetic evidence of a maternal continuity in the Franco-Cantabrian region since pre-Neolithic times

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17 Feb 2012
publication

Genetics. Gene losses in the human genome

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01 Feb 2012
publication

Mitochondrial origin of the matrilocal Mosuo people in China

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12 Dec 2011
publication

Evolutionary genetic dissection of human interferons

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23 Nov 2011
publication

Y-chromosome O3 haplogroup diversity in Sino-Tibetan populations reveals two migration routes into the eastern Himalayas

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23 Oct 2011
publication

Population variation in NAIP functional copy number confers increased cell death upon Legionella pneumophila infection

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18 Oct 2011
publication

Recombination networks as genetic markers in a human variation study of the Old World

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01 Sep 2011
publication

Recombination gives a new insight in the effective population size and the history of the old world human populations

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31 Aug 2011
publication

Human migration through bottlenecks from Southeast Asia into East Asia during Last Glacial Maximum revealed by Y chromosomes

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24 Aug 2011
publication

Genetic ancestry and indigenous heritage in a Native American descendant community in Bermuda

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24 Aug 2011
publication

The selective footprints of viral pressures at the human RIG-I-like receptor family

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09 Jun 2011
publication

Evolution of the TIR domain-containing adaptors in humans: swinging between constraint and adaptation

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01 Jun 2011
publication

Functional characterization of naturally occurring genetic variants in the human TLR1-2-6 gene family

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01 Jun 2011
publication

Lactase persistence in central Asia: phenotype, genotype, and evolution

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13 May 2011
publication

Parallel evolution of genes and languages in the Caucasus region

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01 May 2011
publication

HTLV-2B strains, similar to those found in several Amerindian tribes, are endemic in central African Bakola Pygmies

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20 Apr 2011
publication

An updated tree of Y-chromosome Haplogroup O and revised phylogenetic positions of mutations P164 and PK4

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29 Mar 2011
publication

Evolutionary genetics evidence of an essential, nonredundant role of the IFN-γ pathway in protective immunity

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01 Jan 2011
publication

Human TLRs and IL-1Rs in host defense: natural insights from evolutionary, epidemiological, and clinical genetics

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23 Dec 2010
publication

Positive selection on mitochondrial M7 lineages among the Gelong people in Hainan

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01 Dec 2010
publication

The role played by natural selection on Mendelian traits in humans

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01 Dec 2010
publication

Influences of history, geography, and religion on genetic structure: the Maronites in Lebanon

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01 Dec 2010
publication

A mitochondrial revelation of early human migrations to the Tibetan Plateau before and after the last glacial maximum

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24 Nov 2010
publication

A new method to reconstruct recombination events at a genomic scale

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22 Nov 2010
publication

Life-threatening infectious diseases of childhood: single-gene inborn errors of immunity?

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09 Nov 2010
publication

Ancient DNA from European early neolithic farmers reveals their near eastern affinities

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01 Nov 2010
publication

Insights into the demographic history of African Pygmies from complete mitochondrial genomes

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08 Sep 2010
publication

In the heartland of Eurasia: the multilocus genetic landscape of Central Asian populations

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01 Aug 2010
publication

Genetic heritage and native identity of the Seaconke Wampanoag tribe of Massachusetts

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22 Apr 2010
publication

Formulating a historical and demographic model of recent human evolution based on resequencing data from noncoding regions

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25 Mar 2010
publication

Strong maternal Khoisan contribution to the South African coloured population: a case of gender-biased admixture

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02 Mar 2010
publication

Parkinson’s disease-related LRRK2 G2019S mutation results from independent mutational events in humans

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01 Mar 2010
publication

Human herpesvirus 8, Southern Siberia

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22 Dec 2009
publication

Sexual inequality in tuberculosis

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11 Dec 2009
publication

Positively selected G6PD-Mahidol mutation reduces Plasmodium vivax density in Southeast Asians

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01 Dec 2009
publication

From evolutionary genetics to human immunology: how selection shapes host defence genes

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27 Oct 2009
publication

Study of human RIG-I polymorphisms identifies two variants with an opposite impact on the antiviral immune response

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02 Sep 2009
publication

Evolutionary trajectories of primate genes involved in HIV pathogenesis

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01 Sep 2009
publication

Genetic diversity and the emergence of ethnic groups in Central Asia

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16 Aug 2009
publication

Geographical structure of the Y-chromosomal genetic landscape of the Levant: a coastal-inland contrast

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17 Jul 2009
publication

Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense

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15 Apr 2009
publication

Genetic and demographic implications of the Bantu expansion: insights from human paternal lineages

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10 Apr 2009
publication

Inferring the demographic history of African farmers and pygmy hunter-gatherers using a multilocus resequencing data set

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19 Feb 2009
publication

Signatures of purifying and local positive selection in human miRNAs

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05 Feb 2009
publication

Origins and genetic diversity of pygmy hunter-gatherers from Western Central Africa

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01 Feb 2009
publication

Evolutionary genetics as a tool to target genes involved in phenotypes of medical relevance

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01 Dec 2008
publication

A novel 154-bp deletion in the human mitochondrial DNA control region in healthy individuals

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01 Dec 2008
publication

The genetic legacy of religious diversity and intolerance: paternal lineages of Christians, Jews, and Muslims in the Iberian Peninsula

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30 Oct 2008
publication

Identifying genetic traces of historical expansions: Phoenician footprints in the Mediterranean

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01 Oct 2008
publication

Dynamic nature of the proximal AZFc region of the human Y chromosome: multiple independent deletion and duplication events revealed by microsatellite analysis

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26 Sep 2008
publication

Sex-specific genetic structure and social organization in Central Asia: insights from a multi-locus study

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14 Sep 2008
publication

Maximum-likelihood estimation of site-specific mutation rates in human mitochondrial DNA from partial phylogenetic classification

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05 Sep 2008
publication

Multiple advantageous amino acid variants in the NAT2 gene in human populations

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01 Jul 2008
publication

Protective role of DC-SIGN (CD209) neck-region alleles with <5 repeat units in HIV-1 transmission

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01 Jul 2008
publication

Genetic traces of east-to-west human expansion waves in Eurasia

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24 Apr 2008
publication

The dawn of human matrilineal diversity

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27 Mar 2008
publication

Y-chromosomal diversity in Lebanon is structured by recent historical events

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03 Feb 2008
publication

Natural selection has driven population differentiation in modern humans

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23 Jan 2008
publication

Maternal traces of deep common ancestry and asymmetric gene flow between Pygmy hunter-gatherers and Bantu-speaking farmers

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11 Jan 2008
publication

Demeter’s legacy: rapid changes to our genome imposed by diet

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28 Nov 2007
publication

Population genetic diversity of the NAT2 gene supports a role of acetylation in human adaptation to farming in Central Asia

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01 Nov 2007
publication

Immunology in natura: clinical, epidemiological and evolutionary genetics of infectious diseases

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05 Oct 2007
publication

Promoter and neck region length variation of DC-SIGN is not associated with susceptibility to tuberculosis in Tunisian patients

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14 Sep 2007
publication

TLR3 deficiency in patients with herpes simplex encephalitis

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01 Jun 2007
publication

The Genographic Project public participation mitochondrial DNA database

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01 Jan 2007
publication

From social to genetic structures in central Asia

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04 Dec 2006
publication

Length variation of DC-SIGN and L-SIGN neck-region has no impact on tuberculosis susceptibility

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15 Oct 2006
publication

DC-SIGNR neck-region polymorphisms and HIV-1 susceptibility: From population stratification to a possible advantage of the 7/5 heterozygous genotype

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02 Aug 2006
publication

Evolutionary insights into the high worldwide prevalence of MBL2 deficiency alleles

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31 Jul 2006
publication

Towards a crucial role for DC-SIGN in tuberculosis and beyond

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01 Jul 2006
publication

Sub-Saharan African coding sequence variation and haplotype diversity at the NAT2 gene

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05 Apr 2006
publication

DC-SIGN interacts with Mycobacterium leprae but sequence variation in this lectin is not associated with leprosy in the Pakistani population

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06 Mar 2006
publication

Horizontal transfer of a virulence operon to the ancestor of Mycobacterium tuberculosis

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13 Jan 2006
publication

Deciphering the ancient and complex evolutionary history of human arylamine N-acetyltransferase genes

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11 Jan 2006
publication

The matrilineal ancestry of Ashkenazi Jewry: portrait of a recent founder event

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03 Jan 2006
publication

Promoter variation in the DC-SIGN-encoding gene CD209 is associated with tuberculosis

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01 Jan 2006
publication

[Natural selection of DC-SIGN and its homologues L-SIGN and mSIGNR1 in pathogen recognition and innate immunity]

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29 Sep 2005
publication

The heritage of pathogen pressures and ancient demography in the human innate-immunity CD209/CD209L region

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01 Jan 2005
publication

The Tyr978X BRCA1 mutation: occurrence in non-Jewish Iranians and haplotype in French-Canadian and non-Ashkenazi Jews

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01 Oct 2004
publication

The genetic or mythical ancestry of descent groups: lessons from the Y chromosome

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01 May 2004
publication

MtDNA evidence for a genetic bottleneck in the early history of the Ashkenazi Jewish population

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07 Apr 2004
publication

Where west meets east: the complex mtDNA landscape of the southwest and Central Asian corridor

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10 Feb 2004
publication

Y-chromosomal STR haplotypes in Berber and Arabic-speaking populations from Morocco

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22 Jan 2004
publication

Contrasting patterns of Y chromosome variation in Ashkenazi Jewish and host non-Jewish European populations

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01 Jan 2004
publication

Y chromosome polymorphisms in medicine

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01 Oct 2003
publication

From surnames to the history of Y chromosomes: the Sardinian population as a paradigm

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01 Jul 2003
publication

Male reproductive function and the human Y chromosome: is selection acting on the Y?

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01 Jun 2003
publication

Genetic structure of Mediterranean populations revealed by Y-chromosome haplotype analysis

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01 Jan 2003
publication

Y chromosome haplogroups: a correlation with testicular dysgenesis syndrome?

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19 Oct 2002
publication

Effects of transmission of Y chromosome AZFc deletions

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15 Oct 2002
publication

The fingerprint of phantom mutations in mitochondrial DNA data

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01 Oct 2002
publication

Y-chromosome analysis in Egypt suggests a genetic regional continuity in Northeastern Africa

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01 Jan 2001
publication

The Human Y Chromosome: The Biological Role of a “Functional Wasteland”

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