Laboratoire

Génétique du Développement Humain

Responsable

Kenneth McElreavey

CNRS UMR3738

Département de Biologie du développement & cellules souches

• Cell biology and developmental biology
• Development, developmental genetics, pattern formation and organogenesis
• Genetics
• Genetics, Genomics
• Genomics
• Growth and Morphogenesis
• Non coding RNA
• Population genetics
• Reproduction
• Stem cell biology
• Transdifferentiation
• Congenital heart defects
• Disorders of Sex Development and fertility
• Genetic disorders
• Other diseases
• Pituitary anomalies
• Rare congenital diseases
• Sterility
• Human

VOIR TOUSFermer

Présentation

Désolé, cet article est seulement disponible en Anglais Américain.

Groupes

Group

Anu Bashamboo

Groupe: Anu Bashamboo

Membres

Kenneth McElreavey

Responsable de Structure

Responsable

Joëlle Bignon-Topalovic

Capucine Hyon

Namya Mellouk

Caroline Eozenou

Post-doctorant(e)

Marie-Charlotte Dumargne

Post-doctorant(e)

Anu Bashamboo

Chef(fe) de Groupe

Pierre Calvel

Post-doctorant(e)

Sandra Rojo

Post-doctorant(e)

Laurence Boutout

Personnel Administratif

Grands Projets

LabEx Revive – Biologie régénératrice et médicine

  Objectifs du Consortium ReviveDes avancées scientifiques majeures dans la biologie des cellules souches ont ouvert la voie à des activités de recherche sur la biologie fondamentale de ces cellules et leurs applications cliniques. Le […]

Projets

Germ Cell Development and Maintenance

The specification and differentiation of primordial germs cells (PGCs) into male germ cells is a dynamic process involving a series of synchronised genetic and epigenetic changes that remain ill defined. To understand these events […]

Mammalian Somatic Sex Determination

We have developed a large collection of biological material from patients with urogenital anomalies, through collaborations with clinical centres worldwide. Much of our research activities on sex-determination (i.e. the somatic cells of the gonad) […]

Publications

• 2015
  An ancient protein-DNA interaction underlying metazoan sex determination - Murphy MW, Lee JK, Rojo S, Gearhart MD, Kurahashi K, Banerjee S, Loeuille GA, Bashamboo A, McElreavey K, Zarkower D, Aihara H, Bardwell VJ - Nature structural & molecular biology
• 2015
  Refining the regulatory region upstream of SOX9 associated with 46,XX testicular disorders of sex development (DSD) - Hyon C, Chantot-Bastaraud S, Harbuz R, Bhouri R, Perrot N, Peycelon M, Sibony M, Rojo S, Piguel X, Bilan F, Gilbert-Dussardier B, Kitzis A, McElreavey K, Siffroi JP, Bashamboo A - American journal of medical genetics. Part A
• 2015
  Genetic mutations and somatic anomalies in association with 46,XY gonadal dysgenesis - Bastian C, Muller JB, Lortat-Jacob S, Nihoul-Fékété C, Bignon-Topalovic J, McElreavey K, Bashamboo A, Brauner R - Fertility and sterility
• 2015
  Sperm global DNA methylation level: association with semen parameters and genome integrity - Montjean D, Zini A, Ravel C, Belloc S, Dalleac A, Copin H, Boyer P, McElreavey K, Benkhalifa M - Andrology
• 2014
  Etiology of primary ovarian insufficiency in a series young girls presenting at a pediatric endocrinology center - Brauner R, Pierrepont S, Bignon-Topalovic J, McElreavey K, Bashamboo A - European journal of pediatrics
• 2014
  Gene dosage effects in 46, XY DSD: usefulness of CGH technologies for diagnosis - Jaillard S, Bashamboo A, Pasquier L, Belaud-Rotureau MA, McElreavey K, Odent S, Ravel C - Journal of assisted reproduction and genetics
• 2014
  Mutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathy - Martin CA, Ahmad I, Klingseisen A, Hussain MS, Bicknell LS, Leitch A, Nürnberg G, Toliat MR, Murray JE, Hunt D, Khan F, Ali Z, Tinschert S, Ding J, Keith C, Harley ME, Heyn P, Müller R, Hoffmann I, Daire VC, Dollfus H, Dupuis L, Bashamboo A, McElreavey K, Kariminejad A, Mendoza-Londono R, Moore AT, Saggar A, Schlechter C, Weleber R, Thiele H, Altmüller J, Höhne W, Hurles ME, Noegel AA, Baig SM, Nürnberg P, Jackson AP - Nature genetics
• 2014
  Next generation sequencing for disorders of sex development - Tobias ES, McElreavey K - Endocrine development
• 2014
  Specific aspects of consanguinity: some examples from the Tunisian population - Romdhane L, Ben Halim N, Rejeb I, Kefi R, Bouyacoub Y, Ben Rekaya M, Messai H, Messaoud O, Riahi Z, Bonnet C, Ben Rhouma F, Nagara M, Petit C, McElreavey K, Romeo G, Abdelhak S - Human heredity
• 2014
  Consanguinity and disorders of sex development - Bashamboo A, McElreavey K - Human heredity
• +
  Voir la liste complète de publications

Contact

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Address
25-28 Rue du Docteur Roux
75015, Paris
France