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Host-associated microbes, collectively known as the host microbiota, have manifold effects on host biology. Like other animals, insects establish various symbiotic associations with their microbial communities that shape their individual phenotype and fitness. In […]

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LIPOARBO est une demande d’utilisation de données et d’échantillons collectés chez des participants de la cohorte COSIPOP. Quel est l’objectif ? L’objectif est de déterminer le rôle de certaines protéines humaines présentes dans le […]

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  Herpesviruses envelop glycoproteins     Herpesviridae are a large family of double-stranded DNA viruses, counting more than 200 members that infect humans and a wide range of invertebrates and vertebrates. Herpesviruses carry a […]

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Contexte de l’étude PoxVac22 La variole du singe est une maladie infectieuse apparentée à la variole (éradiquée en 1980), causée par un virus. Ce virus a été décrit pour la première fois chez l’homme […]

Priming mosquito immunity with fungus: A novel strategy to reduce malaria transmission

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Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

This project intends to share expertise, developments, equipement and bioinformatics tools to apply Oxford Nanopore Technology sequencing to the detection, diagnostic and characterization of pathogens of public health importance. It corresponds to a collaboration […]

HB4EIMA est une demande d’utilisation de données et d’échantillons de participants de la cohorte COSIPOP. Quelles données personnelles et quels échantillons collectés auprès des participants sont utilisés ?  Ces personnes ne doivent pas avoir […]

The FURTHEST proposal concerns a multidisciplinary study that focuses on simian foamy viruses (SFVs) which are the most ancient retroviruses. SFVs are prevalent in non-human primates and are transmitted to humans via contact with […]

The ANRS 12225 – PEDIACAM III study involves a cohort of young adolescents infected with HIV placed early (median: 4 months) on antiretroviral therapy (ART) and not infected with HIV monitored in Cameroon. This […]

2016 – 2019         European Commission H2020 A global alliance for Zika virus control and prevention (ZIKALLIANCE) PI: Xavier de Lamballerie (Univ. Aix Marseille) A.-B. Failloux: WP6 Leader (18 partners)

Chronic immune activation during HIV infection is considered as the driving force of CD4+ T cell depletion and AIDS. In cART-treated patients, a residual systemic immune activation persists. It is this chronic low level […]

Dengue virus genotype replacements: investigating viral fitness differences driving the evolution of dengue epidemics Phylogenetic analyses have revealed that dengue virus (DENV) evolutionary dynamics are often characterized by the replacement of a DENV genotype […]

Le monkeypox est un Orthopoxvirus émergent responsable de la variole du singe, une maladie cliniquement similaire à la variole avec une létalité autour de 1 à 10 %. Cette maladie est une zoonose initialement […]

A thousand fold improvement of an antiviral activity The starting point of this project was the modest activity displayed by compounds 1 and 2, on the phenotypic Measles-based antiviral assay designed by Pierre-Olivier Vidalain […]

“Large-scale genomic re-encoding of RNA viruses for producing live-attenuated vaccine candidates” (RNA Vacci-Code)  

The ANRS 12225-Pediacam study is coordinated by Mr. Tejiokem at the Center Pasteur in Cameroon. Since 2007, the project has included children exposed or infected with HIV-1 and a group of unexposed and uninfected […]

Broadly neutralizing HIV-1 antibodies (bNAbs) can develop in rare infected individuals several years after co-evolution with diversifying viruses. In animal models, passive immunotherapy with potent HIV-1 bNAbs has been shown to protect from infection […]

Lymphocytic choriomeningitis virus GP2 envelop protein Arenaviruses are important agents of zoonotic disease worldwide. The virions expose a tripartite envelope glycoprotein complex (GPC) at their surface, formed by the glycoprotein subunits GP1, GP2 and […]

The virulence of a microbe is related to its capacity to invade host tissues and successfully promote its own multiplication and dissemination. Rabies virus, a neurotropic virus that causes fatal encephalitis in mammals, has […]

Bivalent vaccines derived from measles vaccine (F. Tangy, N. Escriou) Major childhood diseases, such as polio or measles, have been virtually eliminated since the 60s thanks to the use of live-attenuated vaccines. Today, millions […]

Several emerging arthropod-borne viruses (arboviruses) such as dengue, yellow fever, chikungunya and Zika viruses originate from sylvatic transmission cycles where they are transmitted among non-human primates by arboreal mosquitoes. Initial virus spillover from the […]

  Cell-cell fusion proteins are essential in development. We show that the C. elegans cell-cell fusion protein EFF-1 is structurally homologous to viral class II fusion proteins. The 2.6 Ang. crystal structure of the […]

Chikungunya virus p62-E1 envelope glycoproteins The Chikungunya virus (CHIKV) is an emerging mosquito-borne alphavirus that has caused widespread outbreaks of a debilitating human disease in the last 5 years. CHIKV invasion of susceptible cells […]

  An unprecedented epidemic of Chikungunya virus (CHIKV) infection recently occurred in countries of the Indian Ocean area, causing an acute and painful syndrome with strong fever, asthenia, skin rash, polyarthritis, and lethal cases […]

Structural and functional studies of Chikungunya virus entry into host cells Deciphering Chikungunya virus cell biology by high-throughput / high-content screening Chikungunya virus infection of fibroblasts Chikungunya virus and the central nervous system infection  

2018 – 2023 “COST Action Aedes Invasive Mosquitoes (AIM)” (European Commission H2020) PI: Alessandra della TORRE (Universitat di Roma Sapienza)

The main objective of the programme is to focus on finding key factors determining dengue transmission and dynamics in order to develop new tools and strategies for controlling dengue transmission. We will estimate the […]

  Dengue virus E envelop glycoprotein The dengue virus (DENV) is a mosquito-borne member of the flavivirus genus responsible for roughly 50 million human infections each year. DENV is composed of four distinct but […]

Le projet EBO-SURSY est financé par l’Union Européenne (UE) à hauteur de 8 millions d’euros. Il a été lancé le 15 janvier 2017 dans 10 pays prioritaires pour une période de 5 ans.   […]

Tick-borne encephalitis virus (TBEV) is a growing health concern in Europe and Asia. It causes severe disease that can lead to permanent neurological complications or death. Recently, the incidence of TBEV infections in endemic […]

2018 – 2020 “ENVironmental changes and mosquito-borne diseases: the example of West Nile (ENVIRON-MOS)” (IPIN) PI: Anna-Bella FAILLOUX (IP Paris)

Cell-Cell fusion in fertilization and developmental biology: a structural biology approach. My group has made seminal contributions in the past toward understanding the mechanism of membrane fusion used by enveloped viruses to infect a […]

The field of insect immunity has been largely dominated by studies on antimicrobial immunity, while antiviral immunity received relatively little attention. The discovery of RNAi as an antiviral mechanism, first in plants and later […]

The field of insect immunity has been largely dominated by studies on antimicrobial immunity, while antiviral immunity received relatively little attention. The discovery of RNAi as an antiviral mechanism, first in plants and later […]

A  collaborative study with members of Pasteur Institute (A. Saez-Cirion, D. Scott-Algara), french perinatal cohort (ANRS CO10; J. Warszawsky) and 10 hospitals from Paris Area (Principal investigator, P. Frange). The study has included 76 […]

In cancer, infection and inflammation, the immune system’s function can be dysregulated, contributing to disease pathology. As part of this process, instead of fighting disease, immune cells may suppress beneficial immune responses and increase […]

Arthropod-borne viruses (arboviruses) pose a major threat to public health worldwide and are continuously (re-)emerging or spreading to uninfected areas. Recent examples notably include dengue, Chikungunya, yellow fever, and Zika virus disease. In addition […]

Dengue is the most rapidly expanding, globally dominant arthropod-borne (arbo) viral disease. It affects close to 400 million people each year in more than 125 countries. Recent reports of autochtonous cases in Southern France […]

The Group for AIDS Research (Groupe de Réflexion SIDA, GRS) organizes  bimonthly meetings and seminars around an HIV / AIDS research topic. Meetings and seminars are open to all. Meetings are usually held on […]

  Hepatitis C virus E2 envelop glycoprotein     The hepatitis C virus (HCV) is a major cause of chronic liver disease worldwide, leading to cirrhosis and hepatocellular carcinoma. In spite of being the focus […]

Mechanisms of HIV-1 replication and interaction with the immune system. More than 35 years after its appearance, the HIV/AIDS epidemic represents more than ever a public health threat worldwide. About 37 million people are […]

The pathogenesis of HIV infection, and in particular the development of immunodeficiency, remains incompletely understood. During HIV infection both innate and adaptive immune responses are raised, but they appear to be insufficient or too […]

Zika virus is an arbovirus responsible for recent epidemics in Polynesia and in the Americas. Clinical descriptions range from mild flu-like syndromes to rare but severe neurological complications such as Guillain-Barré syndrome and encephalitis […]

The objective of this research project is to understand the molecular and functional basis of the memory B-cell antibody response to the SARS-CoV-2 Spike protein. One of the key goals of this research program […]

Rare infected individuals who initiated antiretroviral therapy (ART) very early during primary infection can enter in remission after its interruption, a phenomenon known as post-treatment control. Interestingly, early treatment has been associated with the […]

ICISTEM is a collaborative project to guide and investigate the potential for HIV cure in HIV-infected patients requiring allogeneic stem cell transplantation for hematological disorders. The ICIISTEM consortium is composed of an expert European […]

Collaborative project with UMR Virologie (INRA, ANSES, ENVA), Maisons-Alfort, France. Flaviviruses, which are principally transmitted by mosquitoes and ticks, cause devastating human diseases such as Dengue fever in the tropics and subtropics and are […]

Human T-lymphotropic virus type 1 (HTLV-1) is the etiological agent of a slowly progressive neurodegenerative disease, HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). This disease develops upon infiltration of HTLV-1-infected lymphocytes into the central nervous system, […]

Several enveloped RNA viruses of the Arenaviridae, Bunyaviridae, Filoviridae and Flaviviridae families are associated with a syndrome known as viral hemorrhagic fever (VHF). VHF is characterized by fever, vascular leakage, coagulation defects and multi-organ […]

The interferon (IFN) response protects cells from invading viral pathogens by transcriptionally inducing the expression of interferon-stimulated genes (ISGs). Only a handful of these ISGs have been well characterized, mainly by artificial gain-of-function screening […]

In the frame of a collaboration with Stephen Cusack (EMBL Grenoble) we showed that the direct interaction of the influenza virus polymerase (FluPol) PA subunit to the phosphorylated C-terminal domain of the cellular RNA […]

This project investigates the entomological genetic determinants of human DENV infectiousness to mosquitoes. Specifically, we are testing the hypothesis that mosquitoes are genetically variable in their dose-response to a DENV-infectious blood meal. We recently […]

2019 – 2023 “Mosquito host barriers driving vector specificity for arbovirus transmission (ArboVEC)” (ANR) PI: Kenneth VERNICK (IP Paris)

Specific interactions between host and pathogen genotypes are commonly found in invertebrate systems, but their genetic basis has not been elucidated. Such insect-virus genetic specificity plays a critical role in the emergence and evolution […]

HIV-controllers (HIC) (also called “elite controllers” or “elite suppressors”) are rare (less than 1%) HIV-infected patients who control viral replication to undetectable levels in the absence of antiretroviral treatment. In the context of the […]

http://www.anrs.fr/fr/actualites/412/3-questions-michaela-muller-trutwin

What’s best to study humans and their infectious deseases than Human emulation system ? It’s now possible at Pasteur to develop real Organs-on-chips with cells from different sources, patient derived or cell line. At […]

Our main objective is to increase the knowledge regarding the human virome during homeostasis and diseases. We mainly focus on: immunocompromised patients, where new pathogens and new associations between known pathogens and diseases at found at higher frequency than […]

Rift Valley fever (RVF) is a an arthropod-borne emerging viral disease that primarily affects domesticated animals (such as cattle, sheep and goats) and humans, with recent outbreaks in sub-Saharan Africa, Madagascar, and the Arabian […]

 Bovine Viral Diarrhea virus envelop protein E(rns) Pestiviruses, which belong to the Flaviviridae family of RNA viruses, are important agents of veterinary diseases causing substantial economical losses in animal farming worldwide. Pestivirus particles display […]

  Double-stranded (ds) RNA virus particles are organized around a central icosahedral core capsid made of 120 identical subunits. This core capsid is unable to invade cells from outside, and animal dsRNA viruses have […]

2016 – 2020         European Research Council “Population genomics of co-evolution between non-retroviral RNA viruses and their hosts”; PI: Mariangela Bonizzoni (University of Pavia, Italy)

2018 – 2022 “PREventing EMerging Pathogenic Threats (PREEMPT)” (DARPA) PI: Carla SALEH (IP Paris)

“High-throughput screening of arboviruses in mosquitoes and ticks” (CHIPARBO)

PDB Crystal Structures Resolution (A) Year NON-VIRAL proteins Eukariotyc cell-cell fusion 4OJC Wild-type full-length trimeric ectodomain of C. elegans fusion protein EFF-1  2.93 2014 4OJD C-ter truncated trimeric ectodomain of C. elegans fusion protein […]

Current knowledge of dengue virus (DENV) transmission provides, at best, only a partial understanding of a complicated and dynamic system with a public health track record that has more failures than successes. An important […]

The public health relevance of retroviruses of zoonotic origin is illustrated by the human immunodeficiency virus (HIV) epidemic, the worldwide distribution of human T-lymphotropic viruses (HTLVs), and the morbidity and mortality associated with both […]

2017 – 2022         European Commission H2020 Research capacity for the implementation of genetic control of mosquitoes -2 (Infravec 2) PI: Kenneth VERNICK (Institut Pasteur); A.-B. Failloux: co-leader of WP1 (14 partners)

  Respiratory Syncytial Virus Nucleoprotein-RNA complex     Human respiratory syncytial virus (RSV) is the most important viral agent of pediatric respiratory tract disease worldwide, causing pneumonia and bronchiolitis in infants. No vaccine is currently […]

Knowledge concerning the interaction of SARS-CoV-2 with human and bat cells is sparse. We will use state-of-the-art RNA-sequencing analysis, original bioinformatics tools, loss-of-function approaches and mechanistic studies to identify and characterize coding and non-coding […]

2016 – 2018         Programmes Transversaux de Recherche Risk of reemergence of urban yellow fever in Brazil: role of the invasive mosquito Aedes albopictus PI: Ricardo Lourenço-de-Oliveira (Instituto de Oswaldo Cruz, Rio de Janeiro, Brazil)

The number of persons living with HIV-1 is around 35 million while roughly one million persons are living with HIV-2, with a decreasing prevalence. Both HIV-1 and HIV-2 are associated with AIDS, however most HIV-2 […]

  Little is known about the three-dimensional organization of rubella virus, which causes a relatively mild measles-like disease in children but leads to serious congenital health problems when contracted in utero. Although rubella virus […]

2018 – 2022 “Strengthening Omics Data Analysis Capacities in Pathogen-Host Interaction – PHINDaccess” (European Commission H2020) PI: Helmi Merdassi (Institut Pasteur of Tunis)  

Our project proposes to address, in vitro and in cells infected with Flaviviruses and Coronaviruses, the mechanisms by which enzymes forming the replication transcription complexes i) replicate and transcribe faithfully the RNA genome, ii) […]

Our overall goal is to understand the cellular and molecular aspects of immune response to SARS-CoV-2 virus in terms of activation of over-reactive immunity and induction of immune protection. COVIMUNE is designed to target […]

EVA-GLOBAL objective is to generate the largest accessible collection of human, animal and plant viruses in the world and move beyond the current state-of-the-art to provide an increasingly valuable resource and service to the […]

If you are not a scientist, here’s a simple summary of our research: Insects have an immune system that allows them to live undisturbed when they are infected by a virus that is deadly […]

A collaboration with the electron microscopy expert Cristina Risco (CSIC, Madrid) led us to propose a model in which the endoplasmic reticulum (ER) plays an essential role in the trafficking of newly synthesized viral […]

Dengue is caused by dengue virus (DENV), a virus which can be transmitted by Aedes mosquitos. Half of the world’s population live in areas where the mosquito and the virus are circulating. Infection by […]

Vaccination is one of the greatest successes of modern medicine. The first generation of viral vaccines relied on empiric attenuation by repeated passage in animals and/or cultured cells. A successful attenuation process eliminates virulence […]

The major goal of the vaccine research institute (VRI) consists in boosting the development of a vaccine against HIV.  The VRI is a laboratory of excellence (Labex) created as part of the first PIA […]

Zika virus multiplication and cytopathic effects The Zika virus (ZIKV) epidemics in South East Asia, French Polynesia, the Caribbean islands and the Americas, and its association with neurological disorders including Guillain-Barré syndrome and microcephaly […]

25 leading research and public health organizations from Latin America, North America, Africa, Asia and Europe united to fight Zika virus today and build long-term outbreak response capacity in Latin America. ZikaPLAN takes a […]