Lien vers Pubmed [PMID] – 27246523
J. Allergy Clin. Immunol. 2017 01;139(1):269-280.e7
Animal models have demonstrated that allergen-specific IgG confers sensitivity to systemic anaphylaxis that relies on IgG Fc receptors (FcγRs). Mouse IgG and IgG bind activating FcγRI, FcγRIII, and FcγRIV and inhibitory FcγRIIB; mouse IgG binds only FcγRIII and FcγRIIB. Although these interactions are of strikingly different affinities, these 3 IgG subclasses have been shown to enable induction of systemic anaphylaxis.