APOBEC3C S188I polymorphism enhances context specific editing of Hepatitis B virus genome.

Lien vers Pubmed [PMID] – 35022749

Lien DOI – 10.1093/infdis/jiac003

J Infect Dis 2022 Jan; ():

A single nucleotide polymorphism in APOBEC3C (serine to isoleucine in position 188) is present in ~10% of African populations and greatly enhances restriction against HIV-1 and SIV by improving dimerization and DNA processivity of the enzyme. In this study, we demonstrated in culture and in infected patients that HBV could be edited by APOBEC3CS188I. Using next generation sequencing, we demonstrated that APOBEC3CS188I led to an enhanced editing activity in a more specific 5’TpCpA->5’TpTpA context. This constitutes a new hallmark of this enzyme which could be used to determine its impact on HBV or nuclear DNA.