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2023Interaction network among de novo purine nucleotide biosynthesis enzymes in Escherichia coli., FEBS J 2023 Feb; (): .
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2023Synthesis and structure-activity relationship studies of original cyclic diadenosine derivatives as nanomolar inhibitors of NAD kinase from pathogenic bacteria., Eur J Med Chem 2023 Jan; 246(): 114941.
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2022Structure-based design, synthesis and biological evaluation of a NAD+ analogue targeting Pseudomonas aeruginosa NAD kinase., FEBS J 2022 Aug; (): .
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2021Noncanonical DNA polymerization by aminoadenine-based siphoviruses., Science 2021 04; 372(6541): 520-524.
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2020New Chemical Probe Targeting Bacterial NAD Kinase., Molecules 2020 Oct; 25(21): .
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2020From Substrate to Fragments to Inhibitor Active In Vivo against Staphylococcus aureus., ACS Infect Dis 2020 Mar; 6(3): 422-435.
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2020Fermentation Products of Commensal Bacteria Alter Enterocyte Lipid Metabolism, Cell Host Microbe 2020 March 11;27:1-18.
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2020An expedient synthesis of flexible nucleosides through enzymatic glycosylation of proximal and distal fleximer bases, Chembiochem 2020 Jan;.
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2019Crystal structure of the Trypanosoma cruzi EIF4E5 translation factor homologue in complex with mRNA cap-4, Nucleic Acids Res. 2019 Jun;47(11):5973-5987.
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2019First-in-class allosteric inhibitors of bacterial IMPDHs, Eur J Med Chem 2019 Feb;167:124-132.
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20192′-Deoxyribonucleoside 5′-triphosphates bearing 4-phenyl and 4-pyrimidinyl imidazoles as DNA polymerase substrates, Org. Biomol. Chem. 2019 01;17(2):290-301.
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2018Enzymatic synthesis of random sequences of RNA and RNA analogues by DNA polymerase theta mutants for the generation of aptamer libraries, Nucleic Acids Res. 2018 07;46(12):6271-6284.
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2017An expedient synthesis of flexible nucleosides via a regiocontrolled enzymatic glycosylation of functionalized imidazoles, Org. Biomol. Chem., 2017, 15, 8193.
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20168-Thioalkyl-adenosine derivatives inhibit Listeria monocytogenes NAD kinase through a novel binding mode., Eur J Med Chem 2016 Nov; 124(): 1041-1056.
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2016Expedient and generic synthesis of imidazole nucleosides by enzymatic transglycosylation, Org. Biomol. Chem., 2016, 14, 3638.
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2015The Toxicity of a Novel Antifungal Compound Is Modulated by Endoplasmic Reticulum-Associated Protein Degradation Components, Antimicrob. Agents Chemother. 2015;60(3):1438-49.
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2015Synthetic Routes to Coelenterazine and Other Imidazo[1,2-a]pyrazin-3-one Luciferins: Essential Tools for Bioluminescence-Based Investigations, Chemistry 2015 Nov;21(48):17158-71.
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2015Crystallographic studies of two variants of Pseudomonas aeruginosa IMPDH with impaired allosteric regulation, Acta Crystallogr. D Biol. Crystallogr. 2015 Sep;71(Pt 9):1890-9.
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2015Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH), J. Med. Chem. 2015 Jul;58(14):5579-98.
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2015Unprecedented formation of 8(R),5′-O-cycloribonucleosides through a triflation reaction of purine ribonucleosides, Tetrahedron, 71, 2525-2529..
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2015Two classes of bacterial IMPDHs according to their quaternary structures and catalytic properties, PLoS ONE 2015;10(2):e0116578.
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2015A study of Negishi cross-coupling reactions with benzylzinc halides to prepare original 3-ethoxypyrazoles, Synthesis 2015, 47, 511-516.
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2015[Stimulation of the antiviral innate immune response by pyrimidine biosynthesis inhibitors: a surprise of phenotypic screening], Med Sci (Paris) 2015 Jan;31(1):98-104.
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2015Original 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as inhibitors of human dihydroorotate dehydrogenase (DHODH), J. Med. Chem. 2015 Jan;58(2):860-77.
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2014A convenient synthesis of 4(5)-(hetero)aryl-1H-imidazoles via microwave-assisted Suzuki-Miyaura cross-coupling reaction, Tetrahedron Lett. 2014; 55(46);6347–6350.
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20146-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: synthesis, structural studies and cytotoxic activities, Eur J Med Chem 2014 Oct;85:418-37.
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2014High-throughput screening for broad-spectrum chemical inhibitors of RNA viruses, J Vis Exp 2014;(87).
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2014Synthesis of novel 9-aryl and heteroarylpurine derivatives via copper mediated coupling reaction, Tetrahedron Letters 02/2014; 55(9):1625–1627. .
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2014Bioassay-guided fractionation of extracts from Codiaeum variegatum against Entamoeba histolytica discovers compounds that modify expression of ceramide biosynthesis related genes, PLoS Negl Trop Dis 2014;8(1):e2607.
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2013N (6)-substituted AMPs inhibit mammalian deoxynucleotide N-hydrolase DNPH1, PLoS ONE 2013;8(11):e80755.
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2013Inhibition of pyrimidine biosynthesis pathway suppresses viral growth through innate immunity, PLoS Pathog. 2013;9(10):e1003678.
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2013AutomiG, a biosensor to detect alterations in miRNA biogenesis and in small RNA silencing guided by perfect target complementarity, PLoS ONE 2013;8(9):e74296.
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2013MgATP regulates allostery and fiber formation in IMPDHs, Structure 2013 Jun;21(6):975-85.
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2013High content analysis of primary macrophages hosting proliferating Leishmania amastigotes: application to anti-leishmanial drug discovery, PLoS Negl Trop Dis 2013;7(4):e2154.
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2013Pyrazole-3/5-carboxylic acids from 3/5-trifluoromethyl NH-pyrazoles, Tetrahedron 2013, 69, 257-263.
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2013Preparations of 4-subtituted 3-carboxypyrazoles, J. Heterocycl. Chem. 2013, 50, 1410-1414.
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2012Synthesis and evaluation of 5′-modified thymidines and 5-hydroxymethyl-2′-deoxyuridines as Mycobacterium tuberculosis thymidylate kinase inhibitors, Bioorg. Med. Chem. 2013 Jan;21(1):257-68.
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2012A phenotypic assay to identify Chikungunya virus inhibitors targeting the nonstructural protein nsP2, J Biomol Screen 2013 Feb;18(2):172-9.
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2012Screening and in situ synthesis using crystals of a NAD kinase lead to a potent antistaphylococcal compound., Structure 2012 Jun; 20(6): 1107-17.
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2012Preparation and chemistry of 3/5-halogenopyrazoles, Chem. Rev. 2012 Jul;112(7):3924-58.
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2012The composition of the culture medium influences the β-1,3-glucan metabolism of Aspergillus fumigatus and the antifungal activity of inhibitors of β-1,3-glucan synthesis, Antimicrob. Agents Chemother. 2012 Jun;56(6):3428-31.
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2012Synthesis and evaluation of 6-aza-2′-deoxyuridine monophosphate analogs as inhibitors of thymidylate synthases, and as substrates or inhibitors of thymidine monophosphate kinase in Mycobacterium tuberculosis, Chem. Biodivers. 2012 Mar;9(3):536-56.
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20123-Methoxypyrazoles from 1,1-dimethoxyethene, few original results, Tetrahedron 2012, 68, 3165-3171.
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2012Few unexpected results from a Suzuki-Miyaura reaction, Tetrahedron 2012, 68, 2135-2140.
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2012Drug design and identification of potent leads against mycobacterium tuberculosis thymidine monophosphate kinase, Curr Top Med Chem 2012;12(7):694-705.
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2011Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase, Bioorg. Med. Chem. 2011 Dec;19(24):7603-11.
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2011In-plate protein crystallization, in situ ligand soaking and X-ray diffraction, Acta Crystallogr. D Biol. Crystallogr. 2011 Sep;67(Pt 9):747-55.
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2011On the Knorr synthesis of 6-bromo-4-methylquinolin-2(1H)-one, Synthesis 2011, (6), 934-942.
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2011Simple preparations of 4 and 5-iodinated pyrazoles as useful building blocks, Tetrahedron 2011, 67, 8451-8457.
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2010Structural and functional characterization of the Mycobacterium tuberculosis uridine monophosphate kinase: insights into the allosteric regulation, Nucleic Acids Res. 2011 Apr;39(8):3458-72.
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2010Probing the active site of the deoxynucleotide N-hydrolase Rcl encoded by the rat gene c6orf108, J. Biol. Chem. 2010 Dec;285(53):41806-14.
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2010Design, synthesis and inhibitory activity against Mycobacterium tuberculosis thymidine monophosphate kinase of acyclic nucleoside analogues with a distal imidazoquinolinone, Eur J Med Chem 2010 Dec;45(12):5910-8.
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2010Synthesis, biological activity, and evaluation of the mode of action of novel antitubercular benzofurobenzopyrans substituted on A ring, Eur J Med Chem 2010 Dec;45(12):5833-47.
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2010Characterisation of a DNA polymerase highly mutated along the template binding interface, Mol. Biotechnol. 2010 Sep;46(1):58-62.
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2010Glycosidic Tn-based vaccines targeting dermal dendritic cells favor germinal center B-cell development and potent antibody response in the absence of adjuvant, Blood 2010 Nov;116(18):3526-36.
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2010ATPase inhibitors of heat-shock protein 90, second season, Drug Discov. Today 2010 May;15(9-10):342-53.
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2009Phosphorylation of dGMP analogs by vaccinia virus TMP kinase and human GMP kinase, Biochem. Biophys. Res. Commun. 2009 Oct;388(1):6-11.
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2009Diversity-oriented synthesis of furo[3,2-f]chromanes with antimycobacterial activity, Eur J Med Chem 2009 Jun;44(6):2497-505.
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2009Carbon-4 arylation of 3-alkoxypyrazoles, Tetrahedron 2009, 65, 3529-3535.
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2009Nitrogen’s reactivity of various 3-alkoxypyrazoles, Tetrahedron 2009, 65, 2660-2668.
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2008Crystal structure of poxvirus thymidylate kinase: an unexpected dimerization has implications for antiviral therapy, Proc. Natl. Acad. Sci. U.S.A. 2008 Nov;105(44):16900-5.
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2007Isoxyl activation is required for bacteriostatic activity against Mycobacterium tuberculosis, Antimicrob. Agents Chemother. 2007, 51, 3824-3829.
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