• 2023
  Gedeon A, Karimova G, Ayoub N, Dairou J, Giai Gianetto Q, Vichier-Guerre S, Vidalain PO, Ladant D, Munier-Lehmann H, Interaction network among de novo purine nucleotide biosynthesis enzymes in Escherichia coli., FEBS J 2023 Feb; (): .
• 2023
  Clément DA, Gelin M, Leseigneur C, Huteau V, Mondange L, Pons JL, Dussurget O, Lionne C, Labesse G, Pochet S, , Synthesis and structure-activity relationship studies of original cyclic diadenosine derivatives as nanomolar inhibitors of NAD kinase from pathogenic bacteria., Eur J Med Chem 2023 Jan; 246(): 114941.
• 2022
  Rahimova R, Nogaret P, Huteau V, Gelin M, Clément DA, Labesse G, Pochet S, Blanc-Potard AB, Lionne C, , Structure-based design, synthesis and biological evaluation of a NAD+ analogue targeting Pseudomonas aeruginosa NAD kinase., FEBS J 2022 Aug; (): .
• 2021
  Pezo V, Jaziri F, Bourguignon PY, Louis D, Jacobs-Sera D, Rozenski J, Pochet S, Herdewijn P, Hatfull GF, Kaminski PA, Marliere P, , Noncanonical DNA polymerization by aminoadenine-based siphoviruses., Science 2021 04; 372(6541): 520-524.
• 2020
  Clément DA, Leseigneur C, Gelin M, Coelho D, Huteau V, Lionne C, Labesse G, Dussurget O, Pochet S, , New Chemical Probe Targeting Bacterial NAD Kinase., Molecules 2020 Oct; 25(21): .
• 2020
  Gelin M, Paoletti J, Nahori MA, Huteau V, Leseigneur C, Jouvion G, Dugué L, Clément D, Pons JL, Assairi L, Pochet S, Labesse G, Dussurget O, , From Substrate to Fragments to Inhibitor Active In Vivo against Staphylococcus aureus., ACS Infect Dis 2020 Mar; 6(3): 422-435.
• 2020
  Araújo JR, Tazi A, Burlen-Defranoux O, Vichier-Guerre S, Nigro G, Licandro H, Demignot S, Sansonetti PJ, Fermentation Products of Commensal Bacteria Alter Enterocyte Lipid Metabolism, Cell Host Microbe 2020 March 11;27:1-18.
• 2020
  Vichier-Guerre S, Ku T, Pochet S, Seley-Radtke KL, An expedient synthesis of flexible nucleosides through enzymatic glycosylation of proximal and distal fleximer bases, Chembiochem 2020 Jan;.
• 2019
  Reolon LW, Vichier-Guerre S, de Matos BM, Dugué L, Assunção TRDS, Zanchin NIT, Pochet S, Guimarães BG, Crystal structure of the Trypanosoma cruzi EIF4E5 translation factor homologue in complex with mRNA cap-4, Nucleic Acids Res. 2019 Jun;47(11):5973-5987.
• 2019
  Alexandre T, Lupan A, Helynck O, Vichier-Guerre S, Dugué L, Gelin M, Haouz A, Labesse G, Munier-Lehmann H, First-in-class allosteric inhibitors of bacterial IMPDHs, Eur J Med Chem 2019 Feb;167:124-132.
• 2019
  Vichier-Guerre S, Dugué L, Pochet S, 2′-Deoxyribonucleoside 5′-triphosphates bearing 4-phenyl and 4-pyrimidinyl imidazoles as DNA polymerase substrates, Org. Biomol. Chem. 2019 01;17(2):290-301.
• 2018
  Randrianjatovo-Gbalou I, Rosario S, Sismeiro O, Varet H, Legendre R, Coppée JY, Huteau V, Pochet S, Delarue M, Enzymatic synthesis of random sequences of RNA and RNA analogues by DNA polymerase theta mutants for the generation of aptamer libraries, Nucleic Acids Res. 2018 07;46(12):6271-6284.
• 2017
  S. Vichier-Guerre, L. Dugué, F. Bonhomme and S. Pochet, An expedient synthesis of flexible nucleosides via a regiocontrolled enzymatic glycosylation of functionalized imidazoles, Org. Biomol. Chem., 2017, 15, 8193.
• 2016
  Paoletti J, Assairi L, Gelin M, Huteau V, Nahori MA, Dussurget O, Labesse G, Pochet S, , 8-Thioalkyl-adenosine derivatives inhibit Listeria monocytogenes NAD kinase through a novel binding mode., Eur J Med Chem 2016 Nov; 124(): 1041-1056.
• 2016
  S. Vichier-Guerre, L. Dugué, F. Bonhomme and S. Pochet, Expedient and generic synthesis of imidazole nucleosides by enzymatic transglycosylation, Org. Biomol. Chem., 2016, 14, 3638.
• 2015
  Raj S, Krishnan K, Askew DS, Helynck O, Suzanne P, Lesnard A, Rault S, Zeidler U, d'Enfert C, Latgé JP, Munier-Lehmann H, Saveanu C, The Toxicity of a Novel Antifungal Compound Is Modulated by Endoplasmic Reticulum-Associated Protein Degradation Components, Antimicrob. Agents Chemother. 2015;60(3):1438-49.
• 2015
  Coutant EP, Janin YL, Synthetic Routes to Coelenterazine and Other Imidazo[1,2-a]pyrazin-3-one Luciferins: Essential Tools for Bioluminescence-Based Investigations, Chemistry 2015 Nov;21(48):17158-71.
• 2015
  Labesse G, Alexandre T, Gelin M, Haouz A, Munier-Lehmann H, Crystallographic studies of two variants of Pseudomonas aeruginosa IMPDH with impaired allosteric regulation, Acta Crystallogr. D Biol. Crystallogr. 2015 Sep;71(Pt 9):1890-9.
• 2015
  Lucas-Hourani M, Munier-Lehmann H, El Mazouni F, Malmquist NA, Harpon J, Coutant EP, Guillou S, Helynck O, Noel A, Scherf A, Phillips MA, Tangy F, Vidalain PO, Janin YL, Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH), J. Med. Chem. 2015 Jul;58(14):5579-98.
• 2015
  Claire Amiable and Sylvie Pochet, Unprecedented formation of 8(R),5′-O-cycloribonucleosides through a triflation reaction of purine ribonucleosides, Tetrahedron, 71, 2525-2529..
• 2015
  Alexandre T, Raynal B, Rayna B, Munier-Lehmann H, Two classes of bacterial IMPDHs according to their quaternary structures and catalytic properties, PLoS ONE 2015;10(2):e0116578.
• 2015
  Coutant, E. P.; Janin, Y. L., A study of Negishi cross-coupling reactions with benzylzinc halides to prepare original 3-ethoxypyrazoles, Synthesis 2015, 47, 511-516.
• 2015
  Vidalain PO, Lucas-Hourani M, Helynck O, Tangy F, Munier-Lehmann H, [Stimulation of the antiviral innate immune response by pyrimidine biosynthesis inhibitors: a surprise of phenotypic screening], Med Sci (Paris) 2015 Jan;31(1):98-104.
• 2015
  Munier-Lehmann H, Lucas-Hourani M, Guillou S, Helynck O, Zanghi G, Noel A, Tangy F, Vidalain PO, Janin YL, Original 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as inhibitors of human dihydroorotate dehydrogenase (DHODH), J. Med. Chem. 2015 Jan;58(2):860-77.
• 2014
  Sophie Vichier-Guerre, Laurence Dugué and Sylvie Pochet, A convenient synthesis of 4(5)-(hetero)aryl-1H-imidazoles via microwave-assisted Suzuki-Miyaura cross-coupling reaction, Tetrahedron Lett. 2014; 55(46);6347–6350.
• 2014
  Amiable C, Paoletti J, Haouz A, Padilla A, Labesse G, Kaminski PA, Pochet S, 6-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: synthesis, structural studies and cytotoxic activities, Eur J Med Chem 2014 Oct;85:418-37.
• 2014
  Lucas-Hourani M, Munier-Lehmann H, Helynck O, Komarova A, Desprès P, Tangy F, Vidalain PO, High-throughput screening for broad-spectrum chemical inhibitors of RNA viruses, J Vis Exp 2014;(87).
• 2014
  Laurence Morellato, Valérie Huteau and Sylvie Pochet, Synthesis of novel 9-aryl and heteroarylpurine derivatives via copper mediated coupling reaction, Tetrahedron Letters 02/2014; 55(9):1625–1627. .
• 2014
  Mfotie Njoya E, Weber C, Hernandez-Cuevas NA, Hon CC, Janin Y, Kamini MF, Moundipa PF, Guillén N, Bioassay-guided fractionation of extracts from Codiaeum variegatum against Entamoeba histolytica discovers compounds that modify expression of ceramide biosynthesis related genes, PLoS Negl Trop Dis 2014;8(1):e2607.
• 2013
  Amiable C, Pochet S, Padilla A, Labesse G, Kaminski PA, N (6)-substituted AMPs inhibit mammalian deoxynucleotide N-hydrolase DNPH1, PLoS ONE 2013;8(11):e80755.
• 2013
  Lucas-Hourani M, Dauzonne D, Jorda P, Cousin G, Lupan A, Helynck O, Caignard G, Janvier G, André-Leroux G, Khiar S, Escriou N, Desprès P, Jacob Y, Munier-Lehmann H, Tangy F, Vidalain PO, Inhibition of pyrimidine biosynthesis pathway suppresses viral growth through innate immunity, PLoS Pathog. 2013;9(10):e1003678.
• 2013
  Carré C, Jacquier C, Bougé AL, de Chaumont F, Besnard-Guerin C, Thomassin H, Pidoux J, Da Silva B, Chalatsi E, Zahra S, Olivo-Marin JC, Munier-Lehmann H, Antoniewski C, AutomiG, a biosensor to detect alterations in miRNA biogenesis and in small RNA silencing guided by perfect target complementarity, PLoS ONE 2013;8(9):e74296.
• 2013
  Labesse G, Alexandre T, Vaupré L, Salard-Arnaud I, Him JL, Raynal B, Bron P, Munier-Lehmann H, MgATP regulates allostery and fiber formation in IMPDHs, Structure 2013 Jun;21(6):975-85.
• 2013
  Aulner N, Danckaert A, Rouault-Hardoin E, Desrivot J, Helynck O, Commere PH, Munier-Lehmann H, Späth GF, Shorte SL, Milon G, Prina E, High content analysis of primary macrophages hosting proliferating Leishmania amastigotes: application to anti-leishmanial drug discovery, PLoS Negl Trop Dis 2013;7(4):e2154.
• 2013
  Munier-Lehmann H, Vidalain PO, Tangy F, Janin YL, On dihydroorotate dehydrogenases and their inhibitors and uses, J. Med. Chem. 2013 Apr;56(8):3148-67.
• 2013
  Zeidler U, Bougnoux ME, Lupan A, Helynck O, Doyen A, Garcia Z, Sertour N, Clavaud C, Munier-Lehmann H, Saveanu C, d'Enfert C, Synergy of the antibiotic colistin with echinocandin antifungals in Candida species, J. Antimicrob. Chemother. 2013 Jun;68(6):1285-96.
• 2013
  Padilla A, Amiable C, Pochet S, Kaminski PA, Labesse G, Structure of the oncoprotein Rcl bound to three nucleotide analogues, Acta Crystallogr. D Biol. Crystallogr. 2013 Feb;69(Pt 2):247-55.
• 2013
  Ermolenko, M. S.; Guillou, S.; Janin, Y. L., Pyrazole-3/5-carboxylic acids from 3/5-trifluoromethyl NH-pyrazoles, Tetrahedron 2013, 69, 257-263.
• 2013
  Janin, Y. L., Preparations of 4-subtituted 3-carboxypyrazoles, J. Heterocycl. Chem. 2013, 50, 1410-1414.
• 2012
  Toti KS, Verbeke F, Risseeuw MD, Frecer V, Munier-Lehmann H, Van Calenbergh S, Synthesis and evaluation of 5′-modified thymidines and 5-hydroxymethyl-2′-deoxyuridines as Mycobacterium tuberculosis thymidylate kinase inhibitors, Bioorg. Med. Chem. 2013 Jan;21(1):257-68.
• 2012
  Lucas-Hourani M, Lupan A, Desprès P, Thoret S, Pamlard O, Dubois J, Guillou C, Tangy F, Vidalain PO, Munier-Lehmann H, A phenotypic assay to identify Chikungunya virus inhibitors targeting the nonstructural protein nsP2, J Biomol Screen 2013 Feb;18(2):172-9.
• 2012
  Gelin M, Poncet-Montange G, Assairi L, Morellato L, Huteau V, Dugué L, Dussurget O, Pochet S, Labesse G, , Screening and in situ synthesis using crystals of a NAD kinase lead to a potent antistaphylococcal compound., Structure 2012 Jun; 20(6): 1107-17.
• 2012
  Janin YL, Preparation and chemistry of 3/5-halogenopyrazoles, Chem. Rev. 2012 Jul;112(7):3924-58.
• 2012
  Clavaud C, Beauvais A, Barbin L, Munier-Lehmann H, Latgé JP, The composition of the culture medium influences the β-1,3-glucan metabolism of Aspergillus fumigatus and the antifungal activity of inhibitors of β-1,3-glucan synthesis, Antimicrob. Agents Chemother. 2012 Jun;56(6):3428-31.
• 2012
  Kögler M, Busson R, De Jonghe S, Rozenski J, Van Belle K, Louat T, Munier-Lehmann H, Herdewijn P, Synthesis and evaluation of 6-aza-2′-deoxyuridine monophosphate analogs as inhibitors of thymidylate synthases, and as substrates or inhibitors of thymidine monophosphate kinase in Mycobacterium tuberculosis, Chem. Biodivers. 2012 Mar;9(3):536-56.
• 2012
  Van Calenbergh S, Pochet S, Munier-Lehmann H, Drug design and identification of potent leads against mycobacterium tuberculosis thymidine monophosphate kinase, Curr Top Med Chem 2012;12(7):694-705.
• 2012
  Salanouve, E.; Guillou, S.; Bizouarne, M.; Bonhomme, F. J.; Janin, Y. L., 3-Methoxypyrazoles from 1,1-dimethoxyethene, few original results, Tetrahedron 2012, 68, 3165-3171.
• 2012
  Salanouve, E.; Retailleau, P.; Janin, Y. L., Few unexpected results from a Suzuki-Miyaura reaction, Tetrahedron 2012, 68, 2135-2140.
• 2011
  Van Poecke S, Munier-Lehmann H, Helynck O, Froeyen M, Van Calenbergh S, Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase, Bioorg. Med. Chem. 2011 Dec;19(24):7603-11.
• 2011
  le Maire A, Gelin M, Pochet S, Hoh F, Pirocchi M, Guichou JF, Ferrer JL, Labesse G, In-plate protein crystallization, in situ ligand soaking and X-ray diffraction, Acta Crystallogr. D Biol. Crystallogr. 2011 Sep;67(Pt 9):747-55.
• 2011
  Wlodarczyk, N.; Simenel, C.; Delepierre, M.; Barale, J. C.; Janin, Y. L., On the Knorr synthesis of 6-bromo-4-methylquinolin-2(1H)-one, Synthesis 2011, (6), 934-942.
• 2011
  Guillou, S.; Bonhomme, F. J.; Ermolenko, M. S.; Janin, Y. L., Simple preparations of 4 and 5-iodinated pyrazoles as useful building blocks, Tetrahedron 2011, 67, 8451-8457.
• 2010
  Labesse G, Benkali K, Salard-Arnaud I, Gilles AM, Munier-Lehmann H, Structural and functional characterization of the Mycobacterium tuberculosis uridine monophosphate kinase: insights into the allosteric regulation, Nucleic Acids Res. 2011 Apr;39(8):3458-72.
• 2010
  Dupouy C, Zhang C, Padilla A, Pochet S, Kaminski PA, Probing the active site of the deoxynucleotide N-hydrolase Rcl encoded by the rat gene c6orf108, J. Biol. Chem. 2010 Dec;285(53):41806-14.
• 2010
  Familiar O, Munier-Lehmann H, Aínsa JA, Camarasa MJ, Pérez-Pérez MJ, Design, synthesis and inhibitory activity against Mycobacterium tuberculosis thymidine monophosphate kinase of acyclic nucleoside analogues with a distal imidazoquinolinone, Eur J Med Chem 2010 Dec;45(12):5910-8.
• 2010
  Termentzi A, Khouri I, Gaslonde T, Prado S, Saint-Joanis B, Bardou F, Amanatiadou EP, Vizirianakis IS, Kordulakova J, Jackson M, Brosch R, Janin YL, Daffé M, Tillequin F, Michel S, Synthesis, biological activity, and evaluation of the mode of action of novel antitubercular benzofurobenzopyrans substituted on A ring, Eur J Med Chem 2010 Dec;45(12):5833-47.
• 2010
  Vichier-Guerre S, Jestin JL, Characterisation of a DNA polymerase highly mutated along the template binding interface, Mol. Biotechnol. 2010 Sep;46(1):58-62.
• 2010
  Freire T, Zhang X, Dériaud E, Ganneau C, Vichier-Guerre S, Azria E, Launay O, Lo-Man R, Bay S, Leclerc C, Glycosidic Tn-based vaccines targeting dermal dendritic cells favor germinal center B-cell development and potent antibody response in the absence of adjuvant, Blood 2010 Nov;116(18):3526-36.
• 2010
  Guillou S, Janin YL, 5-Iodo-3-ethoxypyrazoles: an entry point to new chemical entities, Chemistry 2010 Apr;16(15):4669-77.
• 2010
  Janin YL, ATPase inhibitors of heat-shock protein 90, second season, Drug Discov. Today 2010 May;15(9-10):342-53.
• 2010
  Janin, Y. L., Synthetic accesses to 3/5-pyrazole carboxylic acids, Mini Rev. Org. Chem. 2010, 7, 314-323.
• 2010
  Guillou, S.; Bonhomme, F. J.; Chahine, D.; Nesme, O.; Janin, Y. L., N-arylation of 3-alkoxypyrazoles, the case of the pyridines, Tetrahedron 2010, 66, 2654-2663.
• 2009
  Auvynet C, Topalis D, Caillat C, Munier-Lehmann H, Seclaman E, Balzarini J, Agrofoglio LA, Kaminski PA, Meyer P, Deville-Bonne D, El Amri C, Phosphorylation of dGMP analogs by vaccinia virus TMP kinase and human GMP kinase, Biochem. Biophys. Res. Commun. 2009 Oct;388(1):6-11.
• 2009
  Alvey L, Prado S, Saint-Joanis B, Michel S, Koch M, Cole ST, Tillequin F, Janin YL, Diversity-oriented synthesis of furo[3,2-f]chromanes with antimycobacterial activity, Eur J Med Chem 2009 Jun;44(6):2497-505.
• 2009
  Guillou, S.; Nesme, O.; Ermolenko, M. S.; Janin, Y. L., Carbon-4 arylation of 3-alkoxypyrazoles, Tetrahedron 2009, 65, 3529-3535.
• 2009
  Guillou, S.; Bonhomme, F. J.; Janin, Y. L., Nitrogen’s reactivity of various 3-alkoxypyrazoles, Tetrahedron 2009, 65, 2660-2668.
• 2008
  Caillat C, Topalis D, Agrofoglio LA, Pochet S, Balzarini J, Deville-Bonne D, Meyer P, Crystal structure of poxvirus thymidylate kinase: an unexpected dimerization has implications for antiviral therapy, Proc. Natl. Acad. Sci. U.S.A. 2008 Nov;105(44):16900-5.
• 2008
  Binesse J, Delsert C, Saulnier D, Champomier-Vergès MC, Zagorec M, Munier-Lehmann H, Mazel D, Le Roux F, Metalloprotease vsm is the major determinant of toxicity for extracellular products of Vibrio splendidus, Appl. Environ. Microbiol. 2008 Dec;74(23):7108-17.
• 2008
  Alvey L, Prado S, Huteau V, Saint-Joanis B, Michel S, Koch M, Cole ST, Tillequin F, Janin YL, A new synthetic access to furo[3,2-f]chromene analogues of an antimycobacterial, Bioorg. Med. Chem. 2008 Sep;16(17):8264-72.
• 2008
  Familiar O, Munier-Lehmann H, Negri A, Gago F, Douguet D, Rigouts L, Hernández AI, Camarasa MJ, Pérez-Pérez MJ, Exploring acyclic nucleoside analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase, ChemMedChem 2008 Jul;3(7):1083-93.
• 2008
  Kaminski PA, Dacher P, Dugué L, Pochet S, In vivo reshaping the catalytic site of nucleoside 2′-deoxyribosyltransferase for dideoxy- and didehydronucleosides via a single amino acid substitution, J. Biol. Chem. 2008 Jul;283(29):20053-9.
• 2008
  Gasse C, Douguet D, Huteau V, Marchal G, Munier-Lehmann H, Pochet S, Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: synthesis and in vitro anti-mycobacterial activity, Bioorg. Med. Chem. 2008 Jun;16(11):6075-85.
• 2008
  Topalis D, Alvarez K, Barral K, Munier-Lehmann H, Schneider B, Véron M, Guerreiro C, Mulard L, El-Amri C, Canard B, Deville-Bonne D, Acyclic phosphonate nucleotides and human adenylate kinases: impact of a borano group on alpha-P position, Nucleosides Nucleotides Nucleic Acids 2008 Apr;27(4):319-31.
• 2008
  Kaminski PA, Dugué L, Pochet S, Expanding substrate specificity of nucleoside 2′-deoxyribosyltransferase, Nucleic Acids Symp Ser (Oxf) 2008;(52):495-6.
• 2008
  Guillou, S.; Janin, Y. L., Optimized palladium-based approaches to analogues of PK 11195, J. Heterocycl. Chem. 2008, 45, 1377-1384.
• 2008
  Guillou, S.; Bonhomme, F. J.; Janin, Y. L., An improved preparation of 3-alkoxypyrazoles, Synthesis 2008, 3504-3508.
• 2007
  Van Daele I, Munier-Lehmann H, Froeyen M, Balzarini J, Van Calenbergh S, Rational design of 5′-thiourea-substituted alpha-thymidine analogues as thymidine monophosphate kinase inhibitors capable of inhibiting mycobacterial growth, J. Med. Chem. 2007 Nov;50(22):5281-92.
• 2007
  Poncet-Montange G, Assairi L, Arold S, Pochet S, Labesse G, NAD kinases use substrate-assisted catalysis for specific recognition of NAD, J. Biol. Chem. 2007 Nov;282(47):33925-34.
• 2007
  Alexandre JA, Roy B, Topalis D, Pochet S, Périgaud C, Deville-Bonne D, Enantioselectivity of human AMP, dTMP and UMP-CMP kinases, Nucleic Acids Res. 2007;35(14):4895-904.
• 2007
  Topalis D, Kumamoto H, Amaya Velasco MF, Dugué L, Haouz A, Alexandre JA, Gallois-Montbrun S, Alzari PM, Pochet S, Agrofoglio LA, Deville-Bonne D, Nucleotide binding to human UMP-CMP kinase using fluorescent derivatives — a screening based on affinity for the UMP-CMP binding site, FEBS J. 2007 Jul;274(14):3704-14.
• 2007
  Ofiteru A, Bucurenci N, Alexov E, Bertrand T, Briozzo P, Munier-Lehmann H, Gilles AM, Structural and functional consequences of single amino acid substitutions in the pyrimidine base binding pocket of Escherichia coli CMP kinase, FEBS J. 2007 Jul;274(13):3363-73.
• 2007
  Janin YL, Antituberculosis drugs: ten years of research, Bioorg. Med. Chem. 2007 Apr;15(7):2479-513.
• 2007
  Kordulakova, J.; Janin, Y. L.; Liav, A.; Barilone, N.; Vultos, T. D.; Rauzier, J.; Brennan, P. J.; Gicquel, B.; Jackson, M., Isoxyl activation is required for bacteriostatic activity against Mycobacterium tuberculosis, Antimicrob. Agents Chemother. 2007, 51, 3824-3829.
• 2007
  Gasse C, Huteau V, Douguet D, Munier-Lehmann H, Pochet S, A new family of inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase, Nucleosides Nucleotides Nucleic Acids 2007;26(8-9):1057-61.
• 2007
  Topalis D, Kumamoto H, Alexandre JA, Dugué L, Pochet S, Berteina-Raboin S, Agrofoglio LA, Deville-Bonne D, Looking for new pyrimidine acyclic nucleotide analogues designed for phosphorylation by human UMP-CMP kinase, Nucleosides Nucleotides Nucleic Acids 2007;26(10-12):1369-73.
• 2007
  Moriou C, Thomas M, Adeline MT, Martin MT, Chiaroni A, Pochet S, Fourrey JL, Favre A, Clivio P, Crystal structure and photochemical behavior in solution of the 3′-N-sulfamate analogue of thymidylyl(3′-5′)thymidine, J. Org. Chem. 2007 Jan;72(1):43-50.
• 2007
  Prado, S.; Toum, V.; Saint-Joanis, B.; Michel, S.; Koch, M.; Cole, S. T.; Tillequin, F.; Janin, Y. L., Antimycobacterial benzofuro[3,2-f]chromenes from a 5-bromochromen-6-ol, Synthesis 2007, 1566-1570.
• 2006
  Prado S, Janin YL, Saint-Joanis B, Brodin P, Michel S, Koch M, Cole ST, Tillequin F, Bost PE, Synthesis and antimycobacterial evaluation of benzofurobenzopyran analogues, Bioorg. Med. Chem. 2007 Mar;15(5):2177-86.
• 2006
  Freire T, Bay S, Vichier-Guerre S, Lo-Man R, Leclerc C, Carbohydrate antigens: synthesis aspects and immunological applications in cancer, Mini Rev Med Chem 2006 Dec;6(12):1357-73.
• 2006
  Kamiya H, Cadena-Amaro C, Dugué L, Yakushiji H, Minakawa N, Matsuda A, Pochet S, Nakabeppu Y, Harashima H, Recognition of nucleotide analogs containing the 7,8-dihydro-8-oxo structure by the human MTH1 protein, J. Biochem. 2006 Dec;140(6):843-9.
• 2006
  Van Daele I, Munier-Lehmann H, Hendrickx PM, Marchal G, Chavarot P, Froeyen M, Qing L, Martins JC, Van Calenbergh S, Synthesis and biological evaluation of bicyclic nucleosides as inhibitors of M. tuberculosis thymidylate kinase, ChemMedChem 2006 Oct;1(10):1081-90.
• 2006
  Vichier-Guerre S, Ferris S, Auberger N, Mahiddine K, Jestin JL, A population of thermostable reverse transcriptases evolved from Thermus aquaticus DNA polymerase I by phage display, Angew. Chem. Int. Ed. Engl. 2006 Sep;45(37):6133-7.
• 2006
  Frachon E, Bondet V, Munier-Lehmann H, Bellalou J, Multiple microfermentor battery: a versatile tool for use with automated parallel cultures of microorganisms producing recombinant proteins and for optimization of cultivation protocols, Appl. Environ. Microbiol. 2006 Aug;72(8):5225-31.
• 2006
  Bellinzoni M, Haouz A, Graña M, Munier-Lehmann H, Shepard W, Alzari PM, , The crystal structure of Mycobacterium tuberculosis adenylate kinase in complex with two molecules of ADP and Mg2+ supports an associative mechanism for phosphoryl transfer., Protein Sci 2006 Jun; 15(6): 1489-93.
• 2006
  Hible G, Christova P, Renault L, Seclaman E, Thompson A, Girard E, Munier-Lehmann H, Cherfils J, Unique GMP-binding site in Mycobacterium tuberculosis guanosine monophosphate kinase, Proteins 2006 Feb;62(2):489-500.
• 2006
  Prado, S.; Janin, Y. L.; Bost, P. E., A simple two steps ytterbium triflate-catalysed preparation of 2,2-dimethylchromenes from salicylaldehydes and 2-methylpropene, J. Heterocycl. Chem. 2006, 43, 1605-1608.
• 2005
  Topalis D, Collinet B, Gasse C, Dugué L, Balzarini J, Pochet S, Deville-Bonne D, Substrate specificity of vaccinia virus thymidylate kinase, FEBS J. 2005 Dec;272(24):6254-65.
• 2005
  Janin YL, Heat shock protein 90 inhibitors. A text book example of medicinal chemistry?, J. Med. Chem. 2005 Dec;48(24):7503-12.
• 2005
  Jestin JL, Vichier-Guerre S, How to broaden enzyme substrate specificity: strategies, implications and applications, Res. Microbiol. 2005 Dec;156(10):961-6.
• 2005
  Douguet D, Munier-Lehmann H, Labesse G, Pochet S, LEA3D: a computer-aided ligand design for structure-based drug design, J. Med. Chem. 2005 Apr;48(7):2457-68.
• 2005
  Volmer R, Bajramovic JJ, Schneider U, Ufano S, Pochet S, Gonzalez-Dunia D, Mechanism of the antiviral action of 1-beta-D-arabinofuranosylcytosine on Borna disease virus, J. Virol. 2005 Apr;79(7):4514-8.
• 2005
  Cadena-Amaro C, Delepierre M, Pochet S, Synthesis and incorporation into DNA fragments of the artificial nucleobase, 2-amino-8-oxopurine, Bioorg. Med. Chem. Lett. 2005 Feb;15(4):1069-73.
• 2005
  Fioravanti E, Adam V, Munier-Lehmann H, Bourgeois D, The crystal structure of Mycobacterium tuberculosis thymidylate kinase in complex with 3′-azidodeoxythymidine monophosphate suggests a mechanism for competitive inhibition, Biochemistry 2005 Jan;44(1):130-7.
• 2004
  Vanheusden V, Munier-Lehmann H, Froeyen M, Busson R, Rozenski J, Herdewijn P, Van Calenbergh S, Discovery of bicyclic thymidine analogues as selective and high-affinity inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase, J. Med. Chem. 2004 Dec;47(25):6187-94.
• 2004
  León RG, Munier-Lehmann H, Barzu O, Baudin-Creuza V, Pietri R, López-Garriga J, Cadilla CL, High-level production of recombinant sulfide-reactive hemoglobin I from Lucina pectinata in Escherichia coli. High yields of fully functional holoprotein synthesis in the BLi5 E. coli strain, Protein Expr. Purif. 2004 Dec;38(2):184-95.
• 2004
  Lo-Man R, Vichier-Guerre S, Perraut R, Dériaud E, Huteau V, BenMohamed L, Diop OM, Livingston PO, Bay S, Leclerc C, A fully synthetic therapeutic vaccine candidate targeting carcinoma-associated Tn carbohydrate antigen induces tumor-specific antibodies in nonhuman primates, Cancer Res. 2004 Jul;64(14):4987-94.
• 2004
  Vichier-Guerre S, Lo-Man R, Huteau V, Dériaud E, Leclerc C, Bay S, Synthesis and immunological evaluation of an antitumor neoglycopeptide vaccine bearing a novel homoserine Tn antigen, Bioorg. Med. Chem. Lett. 2004 Jul;14(13):3567-70.
• 2004
  Suspène R, Sommer P, Henry M, Ferris S, Guétard D, Pochet S, Chester A, Navaratnam N, Wain-Hobson S, Vartanian JP, APOBEC3G is a single-stranded DNA cytidine deaminase and functions independently of HIV reverse transcriptase, Nucleic Acids Res. 2004;32(8):2421-9.
• 2004
  Bajramovic JJ, Volmer R, Syan S, Pochet S, Gonzalez-Dunia D, 2′-fluoro-2′-deoxycytidine inhibits Borna disease virus replication and spread, Antimicrob. Agents Chemother. 2004 Apr;48(4):1422-5.
• 2004
  Kamiya H, Yakushiji H, Dugué L, Tanimoto M, Pochet S, Nakabeppu Y, Harashima H, Probing the substrate recognition mechanism of the human MTH1 protein by nucleotide analogs, J. Mol. Biol. 2004 Feb;336(4):843-50.
• 2004
  Gallay J, Vincent M, Li de la Sierra IM, Munier-Lehmann H, Renouard M, Sakamoto H, Bârzu O, Gilles AM, Insight into the activation mechanism of Bordetella pertussis adenylate cyclase by calmodulin using fluorescence spectroscopy, Eur. J. Biochem. 2004 Feb;271(4):821-33.
• 2004
  Miron S, Munier-Lehmann H, Craescu CT, Structural and dynamic studies on ligand-free adenylate kinase from Mycobacterium tuberculosis revealed a closed conformation that can be related to the reduced catalytic activity, Biochemistry 2004 Jan;43(1):67-77.
• 2004
  Janin, Y. L.; Decaudin, D.; Monneret, C.; Poupon, M. F., Synthesis of methylenedioxy-bearing 1-aryl-3-carboxylisoquinolines using a modified Ritter reaction procedure, Tetrahedron 2004, 60, 5481-5485.
• 2003
  Pochet S, Kaminski PA, Van Aerschot A, Herdewijn P, Marlière P, Replication of hexitol oligonucleotides as a prelude to the propagation of a third type of nucleic acid in vivo, C. R. Biol. 2003 Dec;326(12):1175-84.
• 2003
  Vanheusden V, Van Rompaey P, Munier-Lehmann H, Pochet S, Herdewijn P, Van Calenbergh S, Thymidine and thymidine-5′-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase, Bioorg. Med. Chem. Lett. 2003 Sep;13(18):3045-8.
• 2003
  Vichier-Guerre S, Lo-Man R, BenMohamed L, Dériaud E, Kovats S, Leclerc C, Bay S, Induction of carbohydrate-specific antibodies in HLA-DR transgenic mice by a synthetic glycopeptide: a potential anti cancer vaccine for human use, J. Pept. Res. 2003 Sep;62(3):117-24.
• 2003
  Vanheusden V, Munier-Lehmann H, Froeyen M, Dugué L, Heyerick A, De Keukeleire D, Pochet S, Busson R, Herdewijn P, Van Calenbergh S, 3′-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase, J. Med. Chem. 2003 Aug;46(18):3811-21.
• 2003
  Van Rompaey, P., Nauwelaerts, K., Vanheusden, V., Rozenski, J., Munier-Lehmann, H., Herdewijn, P. and Van Calenbergh, S., Mycobacterium tuberculosis thymidine monophosphate kinase inhibitors: Biological evaluation and conformational analysis of 2 ‘- and 3 ‘-modified thymidine analogues, Eur. J. Org. Chem., 2003: 2911–2918. doi: 10.1002/ejoc.200300177.
• 2003
  Pochet S, Dugué L, Labesse G, Delepierre M, Munier-Lehmann H, Comparative study of purine and pyrimidine nucleoside analogues acting on the thymidylate kinases of Mycobacterium tuberculosis and of humans, Chembiochem 2003 Aug;4(8):742-7.
• 2003
  Munier-Lehmann H, Chenal-Francisque V, Ionescu M, Chrisova P, Foulon J, Carniel E, Bârzu O, Relationship between bacterial virulence and nucleotide metabolism: a mutation in the adenylate kinase gene renders Yersinia pestis avirulent, Biochem. J. 2003 Jul;373(Pt 2):515-22.
• 2003
  Munier-Lehmann H, Pochet S, Dugue L, Dutruel O, Labesse G, Douget D, Design of Mycobacterium tuberculosis thymidine monophosphate kinase inhibitors, Nucleosides Nucleotides Nucleic Acids 2003 May-Aug;22(5-8):801-4.
• 2003
  Pochet S, Dugué L, Strobel H, Synthesis and recognition by DNA polymerases of a reactive nucleoside for DNA diversification, Nucleosides Nucleotides Nucleic Acids 2003 May-Aug;22(5-8):1665-7.
• 2003
  Sophie Vichier-Guerre, jean-Luc Jestin, Iterative cycles of in vitro protein selection for DNA polymerase activity, Biocatal. Biotransfor. 2003;21(2):75-78.
• 2003
  Fioravanti E, Haouz A, Ursby T, Munier-Lehmann H, Delarue M, Bourgeois D, Mycobacterium tuberculosis thymidylate kinase: structural studies of intermediates along the reaction pathway, J. Mol. Biol. 2003 Apr;327(5):1077-92.
• 2003
  Pasti C, Gallois-Montbrun S, Munier-Lehmann H, Veron M, Gilles AM, Deville-Bonne D, Reaction of human UMP-CMP kinase with natural and analog substrates, Eur. J. Biochem. 2003 Apr;270(8):1784-90.
• 2003
  Lagoja IM, Pochet S, Boudou V, Little R, Lescrinier E, Rozenski J, Herdewijn P, A short path synthesis of [13C/15N] multilabeled pyrimidine nucleosides starting from glucopyranose nucleosides, J. Org. Chem. 2003 Mar;68(5):1867-71.
• 2003
  Janin, Y. L., Peptides with anticancer use or potential, Amino Acids 2003, 25, 1-40.
• 2002
  Strobel H, Dugué L, Marlière P, Pochet S, A parallel synthesis scheme for generating libraries of DNA polymerase substrates and inhibitors, Chembiochem 2002 Dec;3(12):1251-6.
• 2002
  Vanheusden V, Munier-Lehmann H, Pochet S, Herdewijn P, Van Calenbergh S, Synthesis and evaluation of thymidine-5′-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase, Bioorg. Med. Chem. Lett. 2002 Oct;12(19):2695-8.
• 2002
  Johansen TN, Janin YL, Nielsen B, Frydenvang K, Bräuner-Osborne H, Stensbøl TB, Vogensen SB, Madsen U, Krogsgaard-Larsen P, 2-Amino-3-(3-hydroxy-1,2,5-thiadiazol-4-yl)propionic acid: resolution, absolute stereochemistry and enantiopharmacology at glutamate receptors, Bioorg. Med. Chem. 2002 Jul;10(7):2259-66.
• 2002
  Strobel H, Dugué L, Marlière P, Pochet S, Synthesis and recognition by DNA polymerases of a reactive nucleoside, 1-(2-deoxy-beta-D-erythro-pentofuranosyl)-imidazole-4-hydrazide, Nucleic Acids Res. 2002 May;30(9):1869-78.
• 2002
  Bertrand T, Briozzo P, Assairi L, Ofiteru A, Bucurenci N, Munier-Lehmann H, Golinelli-Pimpaneau B, Bârzu O, Gilles AM, Sugar specificity of bacterial CMP kinases as revealed by crystal structures and mutagenesis of Escherichia coli enzyme, J. Mol. Biol. 2002 Feb;315(5):1099-110.
• 2002
  Pochet S, Dugue L, Douguet D, Labesse G, Munier-Lehmann H, Nucleoside analogues as inhibitors of thymidylate kinases: possible therapeutic applications, Chembiochem 2002 Jan;3(1):108-10.
• 2002
  Kamiya H, Dugué L, Yakushiji H, Pochet S, Nakabeppu Y, Harashima H, Substrate recognition by the human MTH1 protein, Nucleic Acids Res. Suppl. 2002;(2):85-6.
• 2001
  Li de la Sierra I, Munier-Lehmann H, Gilles AM, Bârzu O, Delarue M, X-ray structure of TMP kinase from Mycobacterium tuberculosis complexed with TMP at 1.95 A resolution, J. Mol. Biol. 2001 Aug;311(1):87-100.
• 2001
  Vastmans K, Froeyen M, Kerremans L, Pochet S, Herdewijn P, Reverse transcriptase incorporation of 1,5-anhydrohexitol nucleotides, Nucleic Acids Res. 2001 Aug;29(15):3154-63.
• 2001
  Munier-Lehmann H, Chaffotte A, Pochet S, Labesse G, Thymidylate kinase of Mycobacterium tuberculosis: a chimera sharing properties common to eukaryotic and bacterial enzymes, Protein Sci. 2001 Jun;10(6):1195-205.
• 2001
  Lo-Man R, Vichier-Guerre S, Bay S, Dériaud E, Cantacuzène D, Leclerc C, Anti-tumor immunity provided by a synthetic multiple antigenic glycopeptide displaying a tri-Tn glycotope, J. Immunol. 2001 Feb;166(4):2849-54.
• 2001
  Inoue M, Takahashi S, Yamashina I, Kaibori M, Okumura T, Kamiyama Y, Vichier-Guerre S, Cantacuzène D, Nakada H, High density O-glycosylation of the MUC2 tandem repeat unit by N-acetylgalactosaminyltransferase-3 in colonic adenocarcinoma extracts, Cancer Res. 2001 Feb;61(3):950-6.
• 2001
  Miron S, Munier-Lehmann H, Craescu CT, 1H, 13C and 15N resonance assignment and secondary structure of Mycobacterium tuberculosis adenylate kinase, J. Biomol. NMR 2001 Jan;19(1):89-90.
• 2000
  Vastmans K, Pochet S, Peys A, Kerremans L, Van Aerschot A, Hendrix C, Marlière P, Herdewijn P, Enzymatic incorporation in DNA of 1,5-anhydrohexitol nucleotides, Biochemistry 2000 Oct;39(42):12757-65.
• 2000
  Li de la Sierra I, Munier-Lehmann H, Gilles AM, Bârzu O, Delarue M, Crystallization and preliminary X-ray analysis of the thymidylate kinase from Mycobacterium tuberculosis, Acta Crystallogr. D Biol. Crystallogr. 2000 Feb;56(Pt 2):226-8.
• 2000
  Vichier-Guerre S, Lo-Man R, Bay S, Deriaud E, Nakada H, Leclerc C, Cantacuzène D, Short synthetic glycopeptides successfully induce antibody responses to carcinoma-associated Tn antigen, J. Pept. Res. 2000 Feb;55(2):173-80.
• 1999
  Munier-Lehmann H, Burlacu-Miron S, Craescu CT, Mantsch HH, Schultz CP, A new subfamily of short bacterial adenylate kinases with the Mycobacterium tuberculosis enzyme as a model: A predictive and experimental study, Proteins 1999 Aug;36(2):238-48.
• 1999
  Pistotnik E, Sakamoto H, Pochet S, Namane A, Bârzu O, Assay of nucleoside 2-deoxyribosyltransferase activity with pyruvate kinase/lactate dehydrogenase coupling system, Anal. Biochem. 1999 Jul;271(2):192-3.
• 1999
  Lo-Man R, Bay S, Vichier-Guerre S, Dériaud E, Cantacuzène D, Leclerc C, A fully synthetic immunogen carrying a carcinoma-associated carbohydrate for active specific immunotherapy, Cancer Res. 1999 Apr;59(7):1520-4.
• 1996
  Sala M, Pezo V, Pochet S, Wain-Hobson S, Ambiguous base pairing of the purine analogue 1-(2-deoxy-beta-D-ribofuranosyl)-imidazole-4-carboxamide during PCR, Nucleic Acids Res. 1996 Sep;24(17):3302-6.
• 1996
  Pochet S, Marlière P, Construction of a self-complementary nucleoside from deoxyguanosine, C. R. Acad. Sci. III, Sci. Vie 1996 Jan;319(1):1-7.
• 1994
  Mazel D, Pochet S, Marlière P, Genetic characterization of polypeptide deformylase, a distinctive enzyme of eubacterial translation, EMBO J. 1994 Feb;13(4):914-23.
• 1993
  Richaud C, Mengin-Lecreulx D, Pochet S, Johnson EJ, Cohen GN, Marlière P, Directed evolution of biosynthetic pathways. Recruitment of cysteine thioethers for constructing the cell wall of Escherichia coli, J. Biol. Chem. 1993 Dec;268(36):26827-35.
• 1990
  Pochet S, D'Ari R, Synthesis and enzymatic polymerisation of 5-amino-1-(2′-deoxy-beta-D-ribofuranosyl)imidazole-4-carboxamide-5′- triphosphate, Nucleic Acids Res. 1990 Dec;18(23):7127-31.
• 1989
  Arcangioli B, Pochet S, Sousa R, Huynh-Dinh T, Preparation and use of a universal primed Sepharose for the purification of DNA-binding proteins, Eur. J. Biochem. 1989 Feb;179(2):359-63.
• 1988
  Adam S, Ridoux JP, Bourtayre P, Taillandier E, Pochet S, Huynh-Dinh T, Igolen J, IR and UV studies on stability and conformations of short DNA duplexes containing a no-base residue: coexistence of B and Z conformations, J. Biomol. Struct. Dyn. 1988 Aug;6(1):167-79.
• 1988
  Pochet S, Arcangioli B, Huynh-Dinh T, Solid-supported ligation primer, Nucleic Acids Res. 1988 Feb;16(4):1619.
• 1986
  Pochet S, Huynh-Dinh T, Neumann JM, Tran-Dinh S, Adam S, Taboury J, Taillandier E, Igolen J, NMR, CD and IR spectroscopies of a tridecanucleotide containing a no-base residue: coexistence of B and Z conformations, Nucleic Acids Res. 1986 Jan;14(2):1107-26.