• 2024
  March S, Nerurkar N, Jain A, Andrus L, Kim D, Whittaker CA, Tan EKW, Thiberge S, Fleming HE, Mancio-Silva L, Rice CM, Bhatia SN, Autonomous circadian rhythms in the human hepatocyte regulate hepatic drug metabolism and inflammatory responses., Sci Adv 2024 Apr; 10(17): eadm9281.
• 2023
  Carucci M, Duez J, Tarning J, García-Barbazán I, Fricot-Monsinjon A, Sissoko A, Dumas L, Gamallo P, Beher B, Amireault P, Dussiot M, Dao M, Hull MV, McNamara CW, Roussel C, Ndour PA, Sanz LM, Gamo FJ, Buffet P, Safe drugs with high potential to block malaria transmission revealed by a spleen-mimetic screening., Nat Commun 2023 Apr; 14(1): 1951.
• 2023
  Nardella F, Dobrescu I, Hassan H, Rodrigues F, Thiberge S, Mancio-Silva L, Tafit A, Jallet C, Cadet-Daniel V, Goussin S, Lorthiois A, Menon Y, Molinier N, Pechalrieu D, Long C, Sautel F, Matondo M, Duchateau M, Médard G, Witkowski B, Scherf A, Halby L, Arimondo PB, Hemisynthetic alkaloids derived from trilobine are antimalarials with sustained activity in multidrug-resistant Plasmodium falciparum., iScience 2023 Feb; 26(2): 105940.
• 2023
  Fernandes P, Loubens M, Marinach C, Coppée R, Baron L, Grand M, Andre TP, Hamada S, Langlois AC, Briquet S, Bun P, Silvie O, , Plasmodium sporozoites require the protein B9 to invade hepatocytes., iScience 2023 Feb; 26(2): 106056.
• 2022
  Franke-Fayard B, Marin-Mogollon C, Geurten FJA, Chevalley-Maurel S, Ramesar J, Kroeze H, Baalbergen E, Wessels E, Baron L, Soulard V, Martinson T, Aleshnick M, Huijs ATG, Subudhi AK, Miyazaki Y, Othman AS, Kolli SK, Lamers OAC, Roques M, Stanway RR, Murphy SC, Foquet L, Moita D, Mendes AM, Prudêncio M, Dechering KJ, Heussler VT, Pain A, Wilder BK, Roestenberg M, Janse CJ, , Creation and preclinical evaluation of genetically attenuated malaria parasites arresting growth late in the liver., NPJ Vaccines 2022 Nov; 7(1): 139.
• 2022
  Real E, Nardella F, Scherf A, Mancio-Silva L, , Repurposing of Plasmodium falciparum var genes beyond the blood stage., Curr Opin Microbiol 2022 Sep; 70(): 102207.
• 2022
  Scoon WA, Mancio-Silva L, Suder EL, Villacorta-Martin C, Lindstrom-Vautrin J, Bernbaum JG, Mazur S, Johnson RF, Olejnik J, Flores EY, Mithal A, Wang F, Hume AJ, Kaserman JE, March-Riera S, Wilson AA, Bhatia SN, Mühlberger E, Mostoslavsky G, , Ebola virus infection induces a delayed type I IFN response in bystander cells and the shutdown of key liver genes in human iPSC-derived hepatocytes., Stem Cell Reports 2022 Aug; (): .
• 2022
  Luiza-Batista C, Thiberge S, Serra-Hassoun M, Nardella F, Claës A, Nicolete VC, Commère PH, Mancio-Silva L, Ferreira MU, Scherf A, Garcia S, , Humanized mice for investigating sustained Plasmodium vivax blood-stage infections and transmission., Nat Commun 2022 Jul; 13(1): 4123.
• 2022
  Mancio-Silva L, Gural N, Real E, Wadsworth MH, Butty VL, March S, Nerurkar N, Hughes TK, Roobsoong W, Fleming HE, Whittaker CA, Levine SS, Sattabongkot J, Shalek AK, Bhatia SN, , A single-cell liver atlas of Plasmodium vivax infection., Cell Host Microbe 2022 07; 30(7): 1048-1060.e5.
• 2022
  Real E, Mancio-Silva L, , Single-cell views of the Plasmodium life cycle., Trends Parasitol 2022 Jun; (): .
• 2022
  Domenger A, Choisy C, Baron L, Mayau V, Perthame E, Deriano L, Arnulf B, Bories JC, Dadaglio G, Demangel C, , The Sec61 translocon is a therapeutic vulnerability in multiple myeloma., EMBO Mol Med 2022 03; 14(3): e14740.
• 2022
  Keita A, Franetich JF, Carraz M, Valentin L, Bordessoules M, Baron L, Bigeard P, Dupuy F, Geay V, Tefit M, Sarrasin V, Michel S, Lavazec C, Houzé S, Mazier D, Soulard V, Porée FH, Duval R, , Potent Antiplasmodial Derivatives of Dextromethorphan Reveal the Ent-Morphinan Pharmacophore of Tazopsine-Type Alkaloids., Pharmaceutics 2022 Feb; 14(2): .
• 2021
  Romoli O, Mancio-Silva L, Gendrin M, , Linking microbiota composition with antimalarial antibody response., Trends Parasitol 2021 10; 37(10): 853-855.
• 2021
  Blight J, Sala KA, Atcheson E, Kramer H, El-Turabi A, Real E, Dahalan FA, Bettencourt P, Dickinson-Craig E, Alves E, Salman AM, Janse CJ, Ashcroft FM, Hill AV, Reyes-Sandoval A, Blagborough AM, Baum J, , Dissection-independent production of Plasmodium sporozoites from whole mosquitoes., Life Sci Alliance 2021 Jul; 4(7): .
• 2021
  Real E, Howick VM, Dahalan FA, Witmer K, Cudini J, Andradi-Brown C, Blight J, Davidson MS, Dogga SK, Reid AJ, Baum J, Lawniczak MKN, , A single-cell atlas of Plasmodium falciparum transmission through the mosquito., Nat Commun 2021 05; 12(1): 3196.
• 2020
  Yu W, Lescale C, Babin L, Bedora-Faure M, Lenden-Hasse H, Baron L, Demangel C, Yelamos J, Brunet E, Deriano L, , Repair of G1 induced DNA double-strand breaks in S-G2/M by alternative NHEJ., Nat Commun 2020 Oct; 11(1): 5239.
• 2020
  Michailidis E, Vercauteren K, Mancio-Silva L, Andrus L, Jahan C, Ricardo-Lax I, Zou C, Kabbani M, Park P, Quirk C, Pyrgaki C, Razooky B, Verhoye L, Zoluthkin I, Lu WY, Forbes SJ, Chiriboga L, Theise ND, Herzog RW, Suemizu H, Schneider WM, Shlomai A, Meuleman P, Bhatia SN, Rice CM, de Jong YP, , Expansion, in vivo-ex vivo cycling, and genetic manipulation of primary human hepatocytes., Proc Natl Acad Sci U S A 2020 01; 117(3): 1678-1688.
• 2019
  Vera IM, Grilo Ruivo MT, Lemos Rocha LF, Marques S, Bhatia SN, Mota MM, Mancio-Silva L, , Targeting liver stage malaria with metformin., JCI Insight 2019 12; 4(24): .
• 2019
  Ribot JC, Neres R, Zuzarte-Luís V, Gomes AQ, Mancio-Silva L, Mensurado S, Pinto-Neves D, Santos MM, Carvalho T, Landry JJM, Rolo EA, Malik A, Silva DV, Mota MM, Silva-Santos B, Pamplona A, , γδ-T cells promote IFN-γ-dependent Plasmodium pathogenesis upon liver-stage infection., Proc Natl Acad Sci U S A 2019 05; 116(20): 9979-9988.
• 2019
  Chaturantabut S, Shwartz A, Evason KJ, Cox AG, Labella K, Schepers AG, Yang S, Acuña M, Houvras Y, Mancio-Silva L, Romano S, Gorelick DA, Cohen DE, Zon LI, Bhatia SN, North TE, Goessling W, , Estrogen Activation of G-Protein-Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes., Gastroenterology 2019 05; 156(6): 1788-1804.e13.
• 2019
  Werling K, Shaw WR, Itoe MA, Westervelt KA, Marcenac P, Paton DG, Peng D, Singh N, Smidler AL, South A, Deik AA, Mancio-Silva L, Demas AR, March S, Calvo E, Bhatia SN, Clish CB, Catteruccia F, , Steroid Hormone Function Controls Non-competitive Plasmodium Development in Anopheles., Cell 2019 04; 177(2): 315-325.e14.
• 2019
  Mancio-Silva L, Fleming HE, Miller AB, Milstein S, Liebow A, Haslett P, Sepp-Lorenzino L, Bhatia SN, , Improving Drug Discovery by Nucleic Acid Delivery in Engineered Human Microlivers., Cell Metab 2019 03; 29(3): 727-735.e3.
• 2018
  Gural N, Mancio-Silva L, Miller AB, Galstian A, Butty VL, Levine SS, Patrapuvich R, Desai SP, Mikolajczak SA, Kappe SHI, Fleming HE, March S, Sattabongkot J, Bhatia SN, , In Vitro Culture, Drug Sensitivity, and Transcriptome of Plasmodium Vivax Hypnozoites., Cell Host Microbe 2018 Mar; 23(3): 395-406.e4.
• 2018
  Gural N, Mancio-Silva L, He J, Bhatia SN, , Engineered Livers for Infectious Diseases., Cell Mol Gastroenterol Hepatol 2018 ; 5(2): 131-144.
• 2018
  Real E, Rodrigues L, Cabal GG, Enguita FJ, Mancio-Silva L, Mello-Vieira J, Beatty W, Vera IM, Zuzarte-Luís V, Figueira TN, Mair GR, Mota MM, , Plasmodium UIS3 sequesters host LC3 to avoid elimination by autophagy in hepatocytes., Nat Microbiol 2018 Jan; 3(1): 17-25.
• 2018
  Fanny M, Nascimento M, Baron L, Schricke C, Maillet I, Akbal M, Riteau N, Le Bert M, Quesniaux V, Ryffel B, Gombault A, Même S, Même W, Couillin I, , The IL-33 Receptor ST2 Regulates Pulmonary Inflammation and Fibrosis to Bleomycin., Front Immunol 2018 ; 9(): 1476.
• 2017
  Mancio-Silva L, Slavic K, Grilo Ruivo MT, Grosso AR, Modrzynska KK, Vera IM, Sales-Dias J, Gomes AR, MacPherson CR, Crozet P, Adamo M, Baena-Gonzalez E, Tewari R, Llinás M, Billker O, Mota MM, , Nutrient sensing modulates malaria parasite virulence., Nature 2017 07; 547(7662): 213-216.
• 2017
  Meireles P, Sales-Dias J, Andrade CM, Mello-Vieira J, Mancio-Silva L, Simas JP, Staines HM, Prudêncio M, , GLUT1-mediated glucose uptake plays a crucial role during Plasmodium hepatic infection., Cell Microbiol 2017 02; 19(2): .
• 2016
  Baron L, Paatero AO, Morel JD, Impens F, Guenin-Macé L, Saint-Auret S, Blanchard N, Dillmann R, Niang F, Pellegrini S, Taunton J, Paavilainen VO, Demangel C, , Mycolactone subverts immunity by selectively blocking the Sec61 translocon., J Exp Med 2016 12; 213(13): 2885-2896.
• 2016
  Ruivo MTG, Vera IM, Sales-Dias J, Meireles P, Gural N, Bhatia SN, Mota MM, Mancio-Silva L, , Host AMPK Is a Modulator of Plasmodium Liver Infection., Cell Rep 2016 09; 16(10): 2539-2545.
• 2015
  Veigas B, Pedrosa P, Carlos FF, Mancio-Silva L, Grosso AR, Fortunato E, Mota MM, Baptista PV, , One nanoprobe, two pathogens: gold nanoprobes multiplexing for point-of-care., J Nanobiotechnology 2015 Aug; 13(): 48.
• 2015
  Guenin-Macé L, Baron L, Chany AC, Tresse C, Saint-Auret S, Jönsson F, Le Chevalier F, Bruhns P, Bismuth G, Hidalgo-Lucas S, Bisson JF, Blanchard N, Demangel C, , Shaping mycolactone for therapeutic use against inflammatory disorders., Sci Transl Med 2015 May; 7(289): 289ra85.
• 2015
  Mancio-Silva L, Mota MM, , A mediator for malaria stickiness in A versus O blood., Nat Med 2015 Apr; 21(4): 307-8.
• 2015
  Baron L, Gombault A, Fanny M, Villeret B, Savigny F, Guillou N, Panek C, Le Bert M, Lagente V, Rassendren F, Riteau N, Couillin I, , The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine., Cell Death Dis 2015 Feb; 6(): e1629.
• 2014
  Itoe MA, Sampaio JL, Cabal GG, Real E, Zuzarte-Luis V, March S, Bhatia SN, Frischknecht F, Thiele C, Shevchenko A, Mota MM, , Host cell phosphatidylcholine is a key mediator of malaria parasite survival during liver stage infection., Cell Host Microbe 2014 Dec; 16(6): 778-86.
• 2013
  Mancio-Silva L, Lopez-Rubio JJ, Claes A, Scherf A, , Sir2a regulates rDNA transcription and multiplication rate in the human malaria parasite Plasmodium falciparum., Nat Commun 2013 ; 4(): 1530.
• 2013
  Mancio-Silva L, Scherf A, , In situ fluorescence visualization of transcription sites and genomic Loci in blood stages of Plasmodium falciparum., Methods Mol Biol 2013 ; 923(): 335-51.
• 2012
  Riteau N, Baron L, Villeret B, Guillou N, Savigny F, Ryffel B, Rassendren F, Le Bert M, Gombault A, Couillin I, , ATP release and purinergic signaling: a common pathway for particle-mediated inflammasome activation., Cell Death Dis 2012 Oct; 3(): e403.
• 2012
  Sierra-Miranda M, Delgadillo DM, Mancio-Silva L, Vargas M, Villegas-Sepulveda N, Martínez-Calvillo S, Scherf A, Hernandez-Rivas R, , Two long non-coding RNAs generated from subtelomeric regions accumulate in a novel perinuclear compartment in Plasmodium falciparum., Mol Biochem Parasitol 2012 Sep; 185(1): 36-47.
• 2012
  Ribot JC, Debarros A, Mancio-Silva L, Pamplona A, Silva-Santos B, , B7-CD28 costimulatory signals control the survival and proliferation of murine and human γδ T cells via IL-2 production., J Immunol 2012 Aug; 189(3): 1202-8.
• 2012
  Pena AC, Penacho N, Mancio-Silva L, Neres R, Seixas JD, Fernandes AC, Romão CC, Mota MM, Bernardes GJ, Pamplona A, , A novel carbon monoxide-releasing molecule fully protects mice from severe malaria., Antimicrob Agents Chemother 2012 Mar; 56(3): 1281-90.
• 2012
  Gombault A, Baron L, Couillin I, , ATP release and purinergic signaling in NLRP3 inflammasome activation., Front Immunol 2012 ; 3(): 414.
• 2010
  Mancio-Silva L, Zhang Q, Scheidig-Benatar C, Scherf A, , Clustering of dispersed ribosomal DNA and its role in gene regulation and chromosome-end associations in malaria parasites., Proc Natl Acad Sci U S A 2010 Aug; 107(34): 15117-22.
• 2009
  Pérez-Toledo K, Rojas-Meza AP, Mancio-Silva L, Hernández-Cuevas NA, Delgadillo DM, Vargas M, Martínez-Calvillo S, Scherf A, Hernandez-Rivas R, , Plasmodium falciparum heterochromatin protein 1 binds to tri-methylated histone 3 lysine 9 and is linked to mutually exclusive expression of var genes., Nucleic Acids Res 2009 May; 37(8): 2596-606.
• 2009
  Issar N, Ralph SA, Mancio-Silva L, Keeling C, Scherf A, , Differential sub-nuclear localisation of repressive and activating histone methyl modifications in P. falciparum., Microbes Infect 2009 Mar; 11(3): 403-7.
• 2009
  Lopez-Rubio JJ, Mancio-Silva L, Scherf A, , Genome-wide analysis of heterochromatin associates clonally variant gene regulation with perinuclear repressive centers in malaria parasites., Cell Host Microbe 2009 Feb; 5(2): 179-90.
• 2008
  Mancio-Silva L, Rojas-Meza AP, Vargas M, Scherf A, Hernandez-Rivas R, , Differential association of Orc1 and Sir2 proteins to telomeric domains in Plasmodium falciparum., J Cell Sci 2008 Jun; 121(Pt 12): 2046-53.
• 2005
  Freitas-Junior LH, Hernandez-Rivas R, Ralph SA, Montiel-Condado D, Ruvalcaba-Salazar OK, Rojas-Meza AP, Mâncio-Silva L, Leal-Silvestre RJ, Gontijo AM, Shorte S, Scherf A, , Telomeric heterochromatin propagation and histone acetylation control mutually exclusive expression of antigenic variation genes in malaria parasites., Cell 2005 Apr; 121(1): 25-36.
• 2005
  Figueiredo LM, Rocha EP, Mancio-Silva L, Prevost C, Hernandez-Verdun D, Scherf A, , The unusually large Plasmodium telomerase reverse-transcriptase localizes in a discrete compartment associated with the nucleolus., Nucleic Acids Res 2005 ; 33(3): 1111-22.