Désolé, cet article est seulement disponible en anglais américain.
Cliquez pour voir le graph
Connexions
Cliquez pour voir la ligne de temps
Ligne de temps
Présentation
Cours
Resistance to antibacterial agents MOOC
The origin, risks, diagnosis, epidemiology of resistance to antibacterial agents in man and livestock worlwide, as well as preventive and countermeasures, in a « one health » perspective. >>Register here << In 2016, the […]
2023-01-10 09:00:00
2023-03-14 22:00:00
Europe/Paris
Resistance to antibacterial agents MOOC
The origin, risks, diagnosis, epidemiology of resistance to antibacterial agents in man and livestock worlwide, as well as preventive and countermeasures, in a « one health » perspective. >>Register here << In 2016, the […]
Projets Transversaux
Projets
Anciennes Équipes
CV
(EN) Dr. Paola B. Arimondo works at the interface of Chemistry and Biology and develop original chemical tools able (i) to elucidate, at the molecular level, the biological mechanisms that are aberrant in human diseases and (ii) to target these mechanisms aiming at novel therapeutic strategies. She studied Chemistry at the University of Pisa (Scuola Normale Superiore, Italy) and received her Ph.D in Biophysics at the MNHN in Paris. In October 2001, Paola Arimondo was recruited by the CNRS in Paris. Her research focused on the interactions between nucleic acids and proteins and their modulation by small chemical molecules. Initially she developed a strategy to target at a specific DNA site a class of antitumor agents directed against human DNA topoisomerases I and II, resulting in site-specific “DNA scissors”. The strategy was patented and developed in collaboration with a pharmaceutical company, Sigma Tau, Italy. After a six-month sabbatical in 2005 at the University of California in Berkeley, she initiated a new project developing an innovative antitumor strategy aiming at the epigenetic control of gene expression in cancers. In 2011, Paola Arimondo was recruited to lead the Laboratory of Epigenetic Targeting of Cancer (ETaC) USR3388, a joint public-private Laboratory between the CNRS and Pierre Fabre Laboratories, in Toulouse, France. ETaC research projects spanned from the chemistry of the natural products to the discovery of chemical modulators of DNA methylation in cancer. Under her leadership the ETaC laboratory in Toulouse has discovered novel potential drugs and biomarkers. In 2016-2017 she was Oversea Fellow of the Churchill College, Cambridge, UK. In January 2018 she start a new Research Unit Epigenetic Chemical Biology (EpiChBio) at the Institut Pasteur dedicated to the design and use of novel chemical tools to study the molecular mechanisms underlying the aberrant methylation in cancer cells towards a better understanding of the disease and how to target it. The Institut Pasteur offers a unique integrated research frame from microbiology to cancer, from chemistry, structural biology to cellular biology and in vivo experiments. The chemical tools I develop will bring an alternative approach to address the biological questions and, in return, their knowledge and expertise in biology will be a certain asset for our research.
Publications
Télécharger-
2023Design and synthesis of naturally-inspired SARS-CoV-2 inhibitors., RSC Med Chem 2023 Mar; 14(3): 507-519.
-
2023Hemisynthetic alkaloids derived from trilobine are antimalarials with sustained activity in multidrug-resistant Plasmodium falciparum., iScience 2023 Feb; 26(2): 105940.
-
2023EFMC: Trends in Medicinal Chemistry and Chemical Biology, Chemistry Europe.
-
2022DNA methylome combined with chromosome cluster-oriented analysis provides an early signature for cutaneous melanoma aggressiveness., Elife 2022 Sep; 11(): .
-
2022Identification of Chemical Probes Targeting MBD2., ACS Chem Biol 2022.
-
2022Quinazoline-based analog of adenine as an antidote against MLL-rearranged leukemia cells: synthesis, inhibition assays and docking studies., Future Med Chem 2022 04; 14(8): 557-570.
-
2021Direct Synthesis of Allyl Amines with 2-Nitrosulfonamide Derivatives via the Tsuji-Trost Reaction., ChemistryOpen 2021 12; 10(12): 1166-1169.
-
2021Malaria Parasite Stress Tolerance Is Regulated by DNMT2-Mediated tRNA Cytosine Methylation, mBio. 2021 Nov-Dec; 12(6): e02558-21.
-
2021A ruthenium-oligonucleotide bioconjugated photosensitizing aptamer for cancer cell specific photodynamic therapy, RSC Chemical Biology.
-
2021The methylome of Biomphalaria glabrata and other mollusks: enduring modification of epigenetic landscape and phenotypic traits by a new DNA methylation inhibitor., Epigenetics Chromatin 2021 10; 14(1): 48.
-
+Voir la liste complète de publications