Insights into amebiasis using a human 3D-intestinal model (ANR-14-IFEC-0001-02)
This project is a part of the international Infect-Era program, AMOEBAC: Entamoeba histolytica-bacterium interaction and the role of this interaction in intestinal pathogenesis (http://www.infect-era.eu/2nd-call-2014) The aim of this investigation is to understand the induced […]
Understanding the Pathogenicity of Entamoeba Using Comparative Transcriptomics and Phylogenomics – GENAMIBE. Project-ANR-10-GENM-0011
Entamoeba histolytica is a protozoan parasite and an amitochondriate pathogenic amoeba, which may cause dysentery and liver abscess in humans (i.e. amoebiasis). Differential pathogenicity is observed among E. histolytica strains: strain HM1:IMSS is virulent […]
Impact of tissue components on cell migration: adhesion strength, cell morpho-dynamics and intracellular biophysics parameters.
We aim to analyze the impact of substrates on Entamoeba histolytica mode of migration during colonic mucosa invasion using live imaging and quantitative image analysis. E. histolytica, the etiological agent of amoebiasis, is a […]
Imaging and mathematical modelling of cell morphology and motility
Elucidating the mechanisms underlying cell deformation and motility is a topic of major interest in cell biology, for they are strongly involved in cell development, immune responses, cancer and infectious diseases. This projects focuses on the […]
GRAAL: genome assembly from chromosome contact frequencies
A software to reconstruct 1D genome structures from 3D contact data obtained from Hi-C experiments. This movie shows the iterative assembly by GRAAL of the Trichoderma reesei genome (right) using contact frequencies determined by […]
2023Live Cells Imaging and Comparative Phosphoproteomics Uncover Proteins from the Mechanobiome in Entamoeba histolytica., Int J Mol Sci 2023 May; 24(10): .
2023Pathogenicity and virulence of Entamoeba histolytica, the agent of amoebiasis, Virulence. 2023 Dec;14(1):2158656..
2022RNA Sequencing Reveals Widespread Transcription of Natural Antisense RNAs in Entamoeba Species, Microorganisms.
2021Queuine Is a Nutritional Regulator of Entamoeba histolytica Response to Oxidative Stress and a Virulence Attenuator., mBio 2021 Mar; 12(2): .
2021Bioimage Analysis and Cell Motility, Patterns, 2021.
2020Signals and signal transduction pathways in Entamoeba histolytica during the life cycle and when interacting with bacteria or human cells, Molecular Microbiology. 2020;00:1–15.
2020Genomic determinants for initiation and length of natural antisense transcripts in Entamoeba histolytica., Sci Rep 2020 11; 10(1): 20190.
2020Human intestinal models to study interactions between intestine and microbes, Open Biol. 2020 Oct;10(10):200199.
2020Insights into amebiasis using a human 3D-intestinal model., Cell Microbiol 2020 Aug; 22(8): e13203.
2020A Protocol to Quantify Cellular Morphodynamics: From Cell Labelling to Automatic Image Analysis, Eukaryome Impact on Human Intestine Homeostasis and Mucosal Immunology, 2020.
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