Timeline

Najma Rachidi

Permanent Researcher

15 Oct 2024

event

Meeting the EV community @Pasteur – Oct 10, 2024

11 Jul 2023

event

First international conference on CK1 PROTEIN KINASES: “FROM CELL SIGNALING TO THERAPEUTIC TARGETS IN HUMAN DISEASE”

05 Apr 2023

event

Symposium on Microbial Extracellular Vesicles ; June 15th, 2023 ; Auditorium François Jacob

27 Sep 2022

project

ANR Texleish: Targeting host-parasite interactions through the inhibition of excreted leishmania casein kinase 1

22 Sep 2022

project

Pasteur-Weizmann project: Role of kinases in vesicle-mediated regulation of host-pathogen interactions: Focus on Leishmania donovani and Plasmodium falciparum.

22 Sep 2022

project

Parafrap grant : Studying two complementary infection models to identify common mechanisms of intracellular parasite survival: The roles of Leishmania and Eimeria exo-kinases in subversion of host cell signalling.

20 Sep 2022

project

Campus France procope: CASEIN KINASE 1, A KEY REGULATOR OF TUMORIGENESIS AND HOST-PATHOGEN INTERACTIONS

31 May 2022

event

DPT Parasites and insects Vectors Seminar – Neta Regev Rudzki “How malaria parasite tricks its hots”

08 Feb 2022

team

Signalling and host-parasite interactions

01 Jan 2022

publication

Released Parasite-Derived Kinases as Novel Targets for Antiparasitic Therapies.

15 Jan 2021

publication

In vitro identification of imidazo[1,2-a]pyrazine-based antileishmanial agents and evaluation of L. major casein kinase 1 inhibition.

01 Jan 2021

publication

Dangerous Duplicity: The Dual Functions of Casein Kinase 1 in Parasite Biology and Host Subversion.

01 Jan 2021

publication

Identification of the Host Substratome of Leishmania-Secreted Casein Kinase 1 Using a SILAC-Based Quantitative Mass Spectrometry Assay.

20 Feb 2020

publication

SILAC-based quantitative proteomics reveals pleiotropic, phenotypic modulation in primary murine macrophages infected with the protozoan pathogen Leishmania donovani.

24 Oct 2019

event

Symposium “The future of Parasitology”

05 Oct 2019

publication

Structure, regulation, and (patho-)physiological functions of the stress-induced protein kinase CK1 delta (CSNK1D).

01 Sep 2019

publication

The kinase domain of CK1δ can be phosphorylated by Chk1.

22 Aug 2019

event

PhD Defense – Daniel MARTEL -20th September 2019 at 9am: “Functional characterisation of Leishmania casein kinase 1.2 in the parasite and the mammalian host”

18 Apr 2019

publication

CRISPR in Parasitology: Not Exactly Cut and Dried!

25 Mar 2019

publication

Leishmania donovani 90 kD Heat Shock Protein – Impact of Phosphosites on Parasite Fitness, Infectivity and Casein Kinase Affinity.

24 Aug 2018

event

CRISPR in Parasitology Symposium

29 Nov 2017

publication

Characterisation of Casein Kinase 1.1 in Leishmania donovani Using the CRISPR Cas9 Toolkit.

08 Jun 2017

publication

The enemy within: Targeting host-parasite interaction for antileishmanial drug discovery.

02 Jul 2016

publication

Species- and Strain-Specific Adaptation of the HSP70 Super Family in Pathogenic Trypanosomatids.

01 May 2016

publication

From Drug Screening to Target Deconvolution: a Target-Based Drug Discovery Pipeline Using Leishmania Casein Kinase 1 Isoform 2 To Identify Compounds with Antileishmanial Activity.

07 Sep 2015

project

FP7 Targeting the Leishmania kinome for the development of novel anti-parasitic strategies (LeishDrug)

07 Sep 2015

project

ANR TransLeish – Discovery of druggable protein kinases in the protozoan parasite Leishmania donovani using hit compounds identified by phenotypic screening

07 Sep 2015

project

ANR TranSig – Trans-signalling: A novel mechanism of Leishmania host cell immune evasion through the release of parasite signalling proteins

07 Sep 2015

project

PTR 539 – A multilevel systems approach to elucidate the host-Leishmania interactome and to identify host targets for anti-leishmanial drug discovery

11 May 2015

team

Molecular Parasitology and Signaling

08 Apr 2015

publication

A touch of Zen: post-translational regulation of the Leishmania stress response.

01 Sep 2014

publication

Transgenic analysis of the Leishmania MAP kinase MPK10 reveals an auto-inhibitory mechanism crucial for stage-regulated activity and parasite viability.

01 Jul 2014

publication

Probing druggability and biological function of essential proteins in Leishmania combining facilitated null mutant and plasmid shuffle analyses.

18 Feb 2014

publication

Phosphorylation of Sli15 by Ipl1 is important for proper CPC localization and chromosome stability in Saccharomyces cerevisiae.

01 Jan 2014

publication

Pharmacological assessment defines Leishmania donovani casein kinase 1 as a drug target and reveals important functions in parasite viability and intracellular infection.

21 Dec 2012

publication

Apoptotic marker expression in the absence of cell death in staurosporine-treated Leishmania donovani.

02 Nov 2012

publication

Synthesis and biological evaluation of 2,3-diarylimidazo[1,2-a]pyridines as antileishmanial agents.

01 Dec 2009

publication

Ipl1-dependent phosphorylation of Dam1 is reduced by tension applied on kinetochores.

15 May 2007

publication

Ipl1p-dependent phosphorylation of Mad3p is required for the spindle checkpoint response to lack of tension at kinetochores.

01 Dec 2005

publication

Global analysis of protein phosphorylation in yeast.

08 Feb 2002

publication

Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections.

01 Mar 2000

publication

Saccharomyces cerevisiae PAU genes are induced by anaerobiosis.

01 Jan 2000

publication

Examination of the transcriptional specificity of an enological yeast. A pilot experiment on the chromosome-III right arm.

01 Jun 1999

publication

Multiple Ty-mediated chromosomal translocations lead to karyotype changes in a wine strain of Saccharomyces cerevisiae.

18 Jul 1997

publication

Membrane potential-generating malate (MleP) and citrate (CitP) transporters of lactic acid bacteria are homologous proteins. Substrate specificity of the 2-hydroxycarboxylate transporter family.

A little guide for advanced search:

Meeting the EV community @Pasteur – Oct 10, 2024

First international conference on CK1 PROTEIN KINASES: “FROM CELL SIGNALING TO THERAPEUTIC TARGETS IN HUMAN DISEASE”

Symposium on Microbial Extracellular Vesicles ; June 15th, 2023 ; Auditorium François Jacob

ANR Texleish: Targeting host-parasite interactions through the inhibition of excreted leishmania casein kinase 1

Pasteur-Weizmann project: Role of kinases in vesicle-mediated regulation of host-pathogen interactions: Focus on Leishmania donovani and Plasmodium falciparum.

Parafrap grant : Studying two complementary infection models to identify common mechanisms of intracellular parasite survival: The roles of Leishmania and Eimeria exo-kinases in subversion of host cell signalling.

Campus France procope: CASEIN KINASE 1, A KEY REGULATOR OF TUMORIGENESIS AND HOST-PATHOGEN INTERACTIONS

DPT Parasites and insects Vectors Seminar – Neta Regev Rudzki “How malaria parasite tricks its hots”

Signalling and host-parasite interactions

Released Parasite-Derived Kinases as Novel Targets for Antiparasitic Therapies.

In vitro identification of imidazo[1,2-a]pyrazine-based antileishmanial agents and evaluation of L. major casein kinase 1 inhibition.

Dangerous Duplicity: The Dual Functions of Casein Kinase 1 in Parasite Biology and Host Subversion.

Identification of the Host Substratome of Leishmania-Secreted Casein Kinase 1 Using a SILAC-Based Quantitative Mass Spectrometry Assay.

SILAC-based quantitative proteomics reveals pleiotropic, phenotypic modulation in primary murine macrophages infected with the protozoan pathogen Leishmania donovani.

Symposium “The future of Parasitology”

Structure, regulation, and (patho-)physiological functions of the stress-induced protein kinase CK1 delta (CSNK1D).

The kinase domain of CK1δ can be phosphorylated by Chk1.

PhD Defense – Daniel MARTEL -20th September 2019 at 9am: “Functional characterisation of Leishmania casein kinase 1.2 in the parasite and the mammalian host”

CRISPR in Parasitology: Not Exactly Cut and Dried!

Leishmania donovani 90 kD Heat Shock Protein – Impact of Phosphosites on Parasite Fitness, Infectivity and Casein Kinase Affinity.

CRISPR in Parasitology Symposium

Characterisation of Casein Kinase 1.1 in Leishmania donovani Using the CRISPR Cas9 Toolkit.

The enemy within: Targeting host-parasite interaction for antileishmanial drug discovery.

Species- and Strain-Specific Adaptation of the HSP70 Super Family in Pathogenic Trypanosomatids.

From Drug Screening to Target Deconvolution: a Target-Based Drug Discovery Pipeline Using Leishmania Casein Kinase 1 Isoform 2 To Identify Compounds with Antileishmanial Activity.

FP7 Targeting the Leishmania kinome for the development of novel anti-parasitic strategies (LeishDrug)

ANR TransLeish – Discovery of druggable protein kinases in the protozoan parasite Leishmania donovani using hit compounds identified by phenotypic screening

ANR TranSig – Trans-signalling: A novel mechanism of Leishmania host cell immune evasion through the release of parasite signalling proteins

PTR 539 – A multilevel systems approach to elucidate the host-Leishmania interactome and to identify host targets for anti-leishmanial drug discovery

Molecular Parasitology and Signaling

A touch of Zen: post-translational regulation of the Leishmania stress response.

Transgenic analysis of the Leishmania MAP kinase MPK10 reveals an auto-inhibitory mechanism crucial for stage-regulated activity and parasite viability.

Probing druggability and biological function of essential proteins in Leishmania combining facilitated null mutant and plasmid shuffle analyses.

Phosphorylation of Sli15 by Ipl1 is important for proper CPC localization and chromosome stability in Saccharomyces cerevisiae.

Pharmacological assessment defines Leishmania donovani casein kinase 1 as a drug target and reveals important functions in parasite viability and intracellular infection.

Apoptotic marker expression in the absence of cell death in staurosporine-treated Leishmania donovani.

Synthesis and biological evaluation of 2,3-diarylimidazo[1,2-a]pyridines as antileishmanial agents.

Ipl1-dependent phosphorylation of Dam1 is reduced by tension applied on kinetochores.

Ipl1p-dependent phosphorylation of Mad3p is required for the spindle checkpoint response to lack of tension at kinetochores.

Global analysis of protein phosphorylation in yeast.

Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections.

Saccharomyces cerevisiae PAU genes are induced by anaerobiosis.

Examination of the transcriptional specificity of an enological yeast. A pilot experiment on the chromosome-III right arm.

Multiple Ty-mediated chromosomal translocations lead to karyotype changes in a wine strain of Saccharomyces cerevisiae.

Membrane potential-generating malate (MleP) and citrate (CitP) transporters of lactic acid bacteria are homologous proteins. Substrate specificity of the 2-hydroxycarboxylate transporter family.