Exploring immunological mechanisms of graft-versus-host disease and of functional immune tolerance in patients after allogeneic hematopoietic stem cell transplantation
In this project, we build on our previous work of T lymphocyte homeostasis after allogeneic hematopoietic stem cell transplantation (HSCT). We explore early lymphocyte reconstitution and immunological mechanisms of GVHD versus functional immune tolerance. […]
Multiparameter single-cell profiling of human CD4+FOXP3+ regulatory T-cell populations in homeostatic conditions and during graft-versus-host disease
The perspective to harness the potent immunosuppressive activity of CD4+FOXP3+ regulatory T cells (Treg) for clinical applications has sparked enormous interest in this cell population. Recent studies, however, have shown that the human Treg […]
Epigenetic mechanisms controlling the stability and plasticity of CD4+ T cell subsets
Scientific Background Differentiation of naïve CD4+ T lymphocytes into functionally distinct T helper cell subsets is essential for efficient immune responses against different types of pathogens. Effector T cell lineages selectively produce specific sets […]
Linking genotype, cell function and pathology in inflammatory diseases
The past years have been marked by a leap forward in our understanding of the genetic basis of many diseases. In particular, genome-wide association studies (GWAS) have provided insight into the “genetic architecture” of […]
2020Immune response profiling of patients with spondyloarthritis reveals signalling networks mediating TNF-blocker function in vivo., Ann Rheum Dis 2021;80:475-486.
2020Cellular and molecular profiling of T-cell subsets at the onset of human acute GVHD., Blood Adv 2020 Aug; 4(16): 3927-3942.
2019Metabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites., Nat Commun 2019 12; 10(1): 5695.
2019Anti-TNF Therapy in Spondyloarthritis and Related Diseases, Impact on the Immune System and Prediction of Treatment Responses, Front Immunol 2019;10:382.
2018Brief Report: Interleukin-17 Blockade With Secukinumab in Peripheral Spondyloarthritis Impacts Synovial Immunopathology Without Compromising Systemic Immune Responses, 2018 Dec;70(12):1994-2002.
2018Expansion of Interleukin-22- and Granulocyte-Macrophage Colony-Stimulating Factor-Expressing, but Not Interleukin-17A-Expressing, Group 3 Innate Lymphoid Cells in the Inflamed Joints of Patients With Spondyloarthritis, 2018 Sep;.
2018Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors., Nat. Immunol. 2018 03; 19(3): 302-314.
2017Regulatory T cells control toxicity in a humanized model of IL-2 therapy, Nat Commun 2017 11;8(1):1762.
2017Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation, Cell 2017 03;168(6):1086-1100.e10.
2016IL-12 drives functional plasticity of human group 2 innate lymphoid cells, J. Exp. Med. 2016 Apr;213(4):569-83.
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