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Laleh Majlessi, PhD, HDR, is associate professor at Institut Pasteur. She is interested in the interaction between mycobacteria and the etiological agent of human pulmonary tuberculosis, Mycobacterium tuberculosis, with the host immune system and the induction of innate and adaptive anti-mycobacterial immune responses.
Her work on the immunogenicity of substrates of mycobacterial type VII secretion systems has applications in the development of new vaccine candidates against tuberculosis.
Laleh Majlessi was the winner of the Jean-Marie Dubert Prize for the best PhD in immunology from Paris VII University in 1994 and the winner of the Georges, Jacques and Elias Canetti prize in 2016 for her work on mycobacteria.
Publications
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2024A measles-vectored vaccine candidate expressing prefusion-stabilized SARS-CoV-2 spike protein brought to phase I/II clinical trials: candidate selection in a preclinical murine model., J Virol 2024 Apr; (): e0169323.
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2023Full eradication of pre-clinical human papilloma virus-induced tumors by a lentiviral vaccine., EMBO Mol Med 2023 Sep; (): e17723.
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2023Mice Humanized for MHC and hACE2 with High Permissiveness to SARS-CoV-2 Omicron Replication., Microbes Infect 2023 Apr; (): 105142.
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2023Sec61 blockade therapy overrides resistance to proteasome inhibitors and immunomodulatory drugs in multiple myeloma., Front Oncol 2023 ; 13(): 1110916.
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2023Preclinical proof of concept of a tetravalent lentiviral T-cell vaccine against dengue viruses., Front Immunol 2023 ; 14(): 1208041.
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2022Full-Lung Prophylaxis against SARS-CoV-2 by One-Shot or Booster Intranasal Lentiviral Vaccination in Syrian Golden Hamsters, Vaccines (Basel).
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2022A lentiviral vector expressing a dendritic cell-targeting multimer induces mucosal anti-mycobacterial CD4+ T-cell immunity., Mucosal Immunol 2022 Sep; (): .
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2022A lentiviral vector encoding fusion of light invariant chain and mycobacterial antigens induces protective CD4+ T cell immunity., Cell Rep 2022 Jul; 40(4): 111142.
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2022An intranasal lentiviral booster reinforces the waning mRNA vaccine-induced SARS-CoV-2 immunity that it targets to lung mucosa., Mol Ther 2022 Apr; (): .
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2021Brain cross-protection against SARS-CoV-2 variants by a lentiviral vaccine in new transgenic mice., EMBO Mol Med 2021 12; 13(12): e14459.
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