Ivo Gomperts Boneca

We aim to study the adjuvant effects of Enterococcus hirae in antitumoral response. In particular, we want to identify how E. hirae translocates the intestinal barrier and the cells that mediate the antitumor effect.

What’s best to study humans and their infectious deseases than Human emulation system ? It’s now possible at Pasteur to develop real Organs-on-chips with cells from different sources, patient derived or cell line. At […]

The peptidoglycan (PGN) is an essential macromolecule of bacteria composed of a glycan moiety cross-linked by small stem peptides. The assembly of this macromolecule is achieved by protein complexes that involve synthetases, scaffolding proteins […]

The phenomenon of neurogenesis in adult animals, which has therapeutic potential in treating neurodegenerative diseases, leads to several questions: What controls the pattern of connections formed by new cells? How is the stability of […]

The Think tank Mucosal Immunology gathers several research units form the departments of immunology, microbiology, cellular biology and epidemilogy and infection, as well as from the Institut Imagine (Necker) and Hôpital Paul Brousse. It […]

The role of peptidoglycan in bacterial cell physiology: from bacterial shape to host-microbe interactions Peptidoglycan (PGN) is a major essential and unique component of the cell wall of both of Gram-negative and Gram-positive bacteria. […]

We are interested in deciphering the relationships that link gut microbiota with the immune system and the brain. So far, the mechanisms underlying these interplay, and most importantly their consequences, remain largely unknown. Therefore […]

  Our research unit aims at studying peptidoglycan (PGN) metabolism to better understand how bacteria assemble a mature and essential PGN that confers rigidity and shape to the cell despite a highly dynamic process […]

The symbiotic microbiota plays an essential role at many levels of host physiology, and germfree mice develop a large number of defects. In the intestine, the microbiota metabolises nutrients and toxins to generate an […]

We are currently developping new optogenetic tools of interest for System Neuroscience.  Optogenetics is the combination of genetics and optics to control well-defined events within specific cells of living tissue. It includes the discovery and insertion into cells […]