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Présentation
Projets Transversaux
Projets
Anciennes Équipes
CV
2023-2024: Scientific Director in Infectious Diseases Immunology, Moderna, USA
Translational Immunology : establishing Immune profiling and correlates of Immunity for clinical trials and epidemiology studies. Animal models establishment for infectious disease programs (EBV, Norovirus, HIV, Covid, RSV, Flu). Strategizing and Testing mRNA constructs for T cell vaccines.
2022-2023: Associate Scientific Director in Infectious Diseases Immunology, Moderna, USA
Optimization of the mRNA vaccine Initiative lead (T and B cell responses, Durability of mRNA vaccine protection, Increased mucosal immunity, new ROA). HIV Therapeutic program Research lead.
2020-2022 Associate Scientific Director in Platform Immunology, Moderna, USA.
LNP mRNA delivery to Immune cells. Gene editing and writing using LNP mRNA in vivo. Mechanism of infusion related reactions after iv administration of LNP mRNA (clinical samples, biomarkers, Mouse, Rat and NHP models of complement activation and Innate cells inflammation). External innovation and partnership coordination as an SME in Immunology (CARISMA Tx).
2017-2019: Project leader in preclinical applications, Institut Pasteur
Preclinical models for Infectious Diseases (HIV-1).
Start of the creation of a Humanized mice (HIS mice) facility in Pasteur Institute.
Vaccine and immunotherapy assays in vivo.
Hired by Université Paris-Est Créteil (UPEC) for 2 years and Vaccine Research Institue (VRI).
2013-2017: Project leader Immunology/Virology, Institut Pasteur
Infection in humanized mouse (HIS) models (HIV-1, HBV, EBV).
Optimization of humanized mouse models
2010-2013 Project leader, Viroxis, Institut Gustave Roussy
Antigen optimization for a new vaccine strategy.
2007-2009 Post-Doc, Institut Cochin Paris
Role of Tat chromatin cofactors during HIV-1 latency in CD4+ T cells.
2003-2007 PhD Immunology, Université Paris VII Denis Diderot, Institut Pasteur
Role of γc –dependant cytokines in CD4+ T cells effector functions.
Publications
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2022Epitope convergence of broadly HIV-1 neutralizing IgA and IgG antibody lineages in a viremic controller., J Exp Med 2022 Mar; 219(3): .
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2019Accelerated thymopoiesis and improved T-cell responses in HLA-A2/-DR2 transgenic BRGS-based human immune system mice., Eur J Immunol 2019 06; 49(6): 954-965.
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2018A human immune system mouse model with robust lymph node development., Nat Methods 2018 08; 15(8): 623-630.
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2017Humanized mouse models to study pathophysiology and treatment of HIV infection., Curr Opin HIV AIDS 2018 03; 13(2): 143-151.
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2017Regulatory T cells control toxicity in a humanized model of IL-2 therapy, Nat Commun 2017 11;8(1):1762.
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2017A functional DC cross talk promotes human ILC homeostasis in humanized mice., Blood Adv 2017 Apr; 1(10): 601-614.
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2017Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation., Cell 2017 03; 168(6): 1086-1100.e10.
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2016A novel Flt3-deficient HIS mouse model with selective enhancement of human DC development., Eur J Immunol 2016 05; 46(5): 1291-9.
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2008Lymphocytes support oval cell-dependent liver regeneration, J. Immunol. 2008 Aug;181(4):2764-71.
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2007Gamma c cytokines condition the progressive differentiation of CD4+ T cells, Proc. Natl. Acad. Sci. U.S.A. 2007 Sep;104(39):15442-7.
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