David DiGregorio

We have installed a stimulation emission depletion (STED) microscope in order to assess the diversity of the nanoscale organization of synaptic molecules thought to underly synaptic strength and dynamics. Figure 1. Confocal and STED […]

Our CC model predicts that MF-GC STP diversity drives a temporal diversity of GC activity that enables temporal learning by PCs.  Population measurements of GC spiking activity are not readily available. We will use […]

under construction

Computational implications of functional synaptic diversity – a formalized hypothesis. Precise neural representations of “time” are essential for well-timed behaviors [1], but the cellular and circuit mechanisms are largely unknown.  We previously showed that […]

Synaptic representation of multisensory information The GC layer of the CC is thought to pre-process incoming mossy fiber (MF) activity so that PCs can more easily distinguish distinct patterns associated specific sensory contexts. The […]

Contribution of dendritic integration and electrical synapses to circuit computations. Nonlinear summation of synaptic potentials in dendrites is thought to increase computational power of neurons and has been shown to contribute to feature selectivity […]

Molecular and cellular determinants of functional synaptic  diversity At canonical fast synapses nanoscale alterations in the number, density and location of synaptic vesicles, calcium channels, receptors and fusion proteins play a critical role in […]