Humoral immunity & human monoclonal antibodies against SARS-CoV-2
The objective of this research project is to understand the molecular and functional basis of the memory B-cell antibody response to the SARS-CoV-2 Spike protein. One of the key goals of this research program […]
Intestinal and IgA B-cell responses to HIV-1
Mucosal transmission of HIV-1 can induce a local production of IgG and IgA antibodies predominantly targeting the gp41 subunit of the viral envelope glycoprotein gp160. However, whether they limit viral dissemination upon HIV-1 exposure […]
Clonal B cells in HCV-induced cryoglobulinemia vasculitis
Hepatitis C virus (HCV) infection can trigger the development of autoimmune disorders among which, cryobulininemic vasculatitis is the most prevalent. HCV-associated cryobulininemic vasculatitis is mediated by mono-/oligo-clonal IgM cryoglobulins with rheumatoid factor activity, thought […]
Human Antibody Responses to Viruses Adaptive immune responses naturally occurring upon infection or induced by vaccination generate high affinity antibodies, and memory B-cell subsets to respond to further antigenic challenges, providing protection against (re-)infections. […]
2021Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection., Nat Immunol 2021 Sep; (): .
2021Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization., Nature 2021 Jul; (): .
2021Asymptomatic and symptomatic SARS-CoV-2 infections elicit polyfunctional antibodies., Cell Rep Med 2021 May; 2(5): 100275.
2021Sex differences in the evolution of neutralizing antibodies to SARS-CoV-2., J Infect Dis 2021 Mar; (): .
2021CD32+CD4+ T Cells Sharing B Cell Properties Increase With Simian Immunodeficiency Virus Replication in Lymphoid Tissues., Front Immunol 2021 ; 12(): 695148.
2020Syncytia formation by SARS-CoV-2-infected cells., EMBO J 2020 12; 39(23): e106267.
2020A comparison of four serological assays for detecting anti-SARS-CoV-2 antibodies in human serum samples from different populations., Sci Transl Med 2020 09; 12(559): .
2020Potent human broadly neutralizing antibodies to hepatitis B virus from natural controllers., J. Exp. Med. 2020 ; 217(10): .