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Présentation
Projets
CV
Education |
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1998-2001 |
Ph.D. in Biology and Pharmacology of Hemostasis and Vessels / University Paris Diderot (B2T), Paris 7 |
1997 |
Master II (DEA) in Biology and Pharmacology of Hemostasis and Vessels / University Paris 7 (B2T) |
1991-1996 |
Degree in Biochemistry (DEUG/Licence/Master I) / University P& M Curie, Paris 6 |
Positions and Professional Experiences |
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2014-now |
Research engineer, Institut Pasteur. →½ time: HIV, Inflammation & Persistence Unit (M. Müller-Trutwin). Regulation of inflammation in monkeys resistant or susceptible to AIDS →½ time: Ebola Task Force (P. Lafayes’ Work Package). Development of a diagnostic point-of-care test for Ebola virus (collaboration with P. Tabeling & L. Magro, ESPCI) →summer 2015: visiting scientist, CTE of Macenta, Guinea. Diagnostic of Ebola |
2007-2014 |
Research engineer, Regulation of Retroviral Infections Unit (F. Barré-Sinoussi, M. Müller-Trutwins’ team), Institut Pasteur. Immunoregulation of SIV infection in monkeys resistant to AIDS |
2004-2007 |
Research engineer, Platform 2 / DNA microarrays, Institut Pasteur. GPH # 2 “AIDS”, sub-program #1 leaded by M. Müller-Trutwin: Gene expression profiles and signaling pathways differentially regulated in monkeys resistant or susceptible to AIDS |
2002-2004 |
Postdoctoral position as research engineer, CEA (D. Tronik-Leroux laboratory), Genopole of Evry, France: Gene expression profiles during megakaryocytopoiesis in mice |
2002 |
Postdoctoral position, UMR 5533 CNRS (AT. Nurdens’ laboratory), Bordeaux, France: Impact of platelet glycoproteins polymorphisms in cardiovascular diseases |
1998-2001 |
TJ. Kunickis’ laboratory, MEM, The Scripps Research Institute, La Jolla, USA: Study of the factors influencing the integrin alpha-2 gene transcription |
1997 |
UMR 5533 CNRS (AT. Nurdens’ laboratory), Bordeaux, France: Construction of a physical map of Protease-Activated Receptor genes on 5q13 |
Training |
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2015 |
Training to work on Ebola-infected biological samples (PSM III, Diagnostic tests…)/ Institut Pasteur |
2008 |
Basics in Biostatistics / University Paris Diderot, Paris 7 |
2008 |
Quality Basics / Institut Pasteur |
2007 |
Animal experimentation level I / Veterinary School of Alfort |
Skills |
Scientific Broad range of biomedical laboratory techniques, including nucleic acid handling and related assays, qRT-PCR, library constructions, cloning, microarrays, PFGE, western-blot, ELISA, PBMC isolation, magnetic cell separation, cell culture techniques… Biosafety level 3 working, SIV/HIV quantifications, handling of human and simian infected samples… Data analysis (Office, EndNote, GraphPad Prism, Statview, Blast, Clustal-W, Photoshop…) Project management, grant writing… |
Training 2007-2011: Co-supervision of a graduate student (IP) 2004-2007: Supervision of a master student and a graduate student (IP) |
Teaching 2012: Course on Animal models for AIDS for the “Université des Jeunes Chercheurs” (Sidaction), Carry-le-Rouet. 2004-2007: Teaching of the practical part of the “Mouse genetics course” on DNA microarrays (IP) |
Other activities 2008-2015: In co-charge of the “quality“ supervision for the Unit 2008-2013: Member of the editorial board of the vih.org website 2007-2013: In co-charge of the transcriptomic platform for nonhuman primates and of the french preclinical research database website of the ANRS 2002-2004: Coordinator for the CEA of the Genopole journal “FORUM” |
Languages French (native speaker), English (fluent) |
Publications
Télécharger-
2023SARS-CoV-2 viral persistence in lung alveolar macrophages is controlled by IFN-γ and NK cells., Nat Immunol 2023 Nov; (): .
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2022NK cell spatial dynamics and IgA responses in gut-associated lymphoid tissues during SIV infections., Commun Biol 2022 Jul; 5(1): 674.
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2021NK-B cell cross talk induces CXCR5 expression on natural killer cells., iScience 2021 Oct; 24(10): 103109.
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2021Interests of the Non-Human Primate Models for HIV Cure Research., Vaccines (Basel) 2021 Aug; 9(9): .
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2021IL-21 and IFNα therapy rescues terminally differentiated NK cells and limits SIV reservoir in ART-treated macaques., Nat Commun 2021 05; 12(1): 2866.
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2021Role of NKG2a/c+CD8+ T cells in pathogenic versus non-pathogenic SIV infections., iScience 2021 Apr; 24(4): 102314.
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2021SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity., Nat Commun 2021 02; 12(1): 1282.
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2021Analysis and annotation of DNA methylation in two nonhuman primate species using the Infinium Human Methylation 450K and EPIC BeadChips., Epigenomics 2021 02; 13(3): 169-186.
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2021CD32+CD4+ T Cells Sharing B Cell Properties Increase With Simian Immunodeficiency Virus Replication in Lymphoid Tissues., Front Immunol 2021 ; 12(): 695148.
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2020DNA methylation changes in metabolic and immune-regulatory pathways in blood and lymph node CD4 + T cells in response to SIV infections., Clin Epigenetics 2020 Dec; 12(1): 188.
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