Integrating the activities of SUMO in gene expression, inflammation and cancer (ERC-2011-AdG SUMOSTRESS)
Sumoylation of proteins has emerged as a central regulatory mechanism influencing a wide range of cellular processes and is notably a key pathway facilitating cellular response to stress. Gene expression appears to be particularly […]
Chromatin role of SUMO in oncogenesis
Like cellular reprogramming to stem cell fates, tumorigenesis is characterized by dysregulated cellular plasticity which facilitates the emergence of cancer cells, their survival and metastatic escape from the tumoral environment. While the contribution of […]
Deconstructing the role of SUMO on chromatin in cell identity and tissue repair (ERC-2018-AdG SUMiDENTITY)
The maintenance of cell identity and how it is subverted in disease are central questions in biology and medicine. The interplay between transcription factor and chromatin configurations plays a key role in maintaining cellular […]
2020SUMOylation of Enzymes and Ion Channels in Sensory Neurons Protects against Metabolic Dysfunction, Neuropathy, and Sensory Loss in Diabetes., Neuron 2020 09; 107(6): 1141-1159.e7.
2020An unanticipated tumor-suppressive role of the SUMO pathway in the intestine unveiled by Ubc9 haploinsufficiency., Oncogene 2020 Sep; (): .
2020Extensive SUMO Modification of Repressive Chromatin Factors Distinguishes Pluripotent from Somatic Cells., Cell Rep 2020 09; 32(11): 108146.
2018SUMO safeguards somatic and pluripotent cell identities by enforcing distinct chromatin states, Cell Stem Cell. 2018 Nov 1;23(5):742-757.e8. doi: 10.1016/j.stem.2018.10.001.
2017entry unveils a calcium/calpain-dependent mechanism for inhibiting sumoylation, Elife 2017 12;6.