👏🥳 Congrats to Lucas Paoli and all authors for this collective effort, from data generation to analysis and discussion, and to the broader community whose tools, datasets, and ideas made this work possible (YAY iModulons).
Présentation
Membres
Aude Bernheim
Responsable de Structure
Responsable
Anciens Membres
2000
2000
Name
Position
2023
2024
Lucas Paoli
Post doc, now Group Leader at EPFL https://www.epfl.ch/labs/gr-paoli/
2021
2024
Helena Shomar
Post doc, now Senior Scientist in En Carta Diagnostics
Publications
Find updated list of publications on https://mdmlab.fr/publications/
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2025Structural basis for Lamassu-based antiviral immunity and its evolution from DNA repair machinery., Proc Natl Acad Sci U S A 2025 Nov; 122(47): e2519643122.
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2025A human homolog of SIR2 antiphage proteins mediates immunity via the Toll-like receptor pathway, Science, 2025, 389 (6758), pp.eadr8536. ⟨10.1126/science.adr8536⟩.
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2025Sedentary chromosomal integrons as biobanks of bacterial antiphage defense systems., Science, 2025 May; 388(6747): eads0768.
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2025Evolutionary origins of archaeal and eukaryotic RNA-guided RNA modification in bacterial IS110 transposons., Nat Microbiol 2025 Jan; (): .
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2025Strain phylogroup and environmental constraints shape Escherichia coli dynamics and diversity over a 20-year human gut time series, The International Society of Microbiologial Ecology Journal, 2025, 19 (1), ⟨10.1093/ismejo/wrae245⟩.
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2024Exploring the diversity of anti-defense systems across prokaryotes, phages and mobile genetic elements., Nucleic Acids Res 2024 Dec; (): .
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2024Prediction of strain level phage-host interactions across the Escherichia genus using only genomic information., Nat Microbiol 2024 Nov; 9(11): 2847-2861.
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2024Conservation of antiviral systems across domains of life reveals immune genes in humans, Cell Host & Microbe, 2024, 32 (9), pp.1594-1607.e5. ⟨10.1016/j.chom.2024.08.002⟩.
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2024A virally encoded tRNA neutralizes the PARIS antiviral defence system, Nature, 2024, 634 (8033), pp.424-431. ⟨10.1038/s41586-024-07874-3⟩.
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2024Viperin immunity evolved across the tree of life through serial innovations on a conserved scaffold, Nature Ecology & Evolution, 2024, 8 (9), pp.667-1679. ⟨10.1038/s41559-024-02463-z⟩.
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+Voir la liste complète de publications




