🚨Preprint alert - this is a big one! We transfer the revolutionary power of TnSeq to bacteriophages. Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms. A thread 1/8
Présentation
Membres
Aude Bernheim
Responsable de Structure
Responsable
Anciens Membres
2000
2000
Name
Position
2023
2024
Lucas Paoli
Post doc, now Group Leader at EPFL https://www.epfl.ch/labs/gr-paoli/
2021
2024
Helena Shomar
Post doc, now Senior Scientist in En Carta Diagnostics
Publications
Find updated list of publications on https://mdmlab.fr/publications/
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2025A human homolog of SIR2 antiphage proteins mediates immunity via the Toll-like receptor pathway, Science, 2025, 389 (6758), pp.eadr8536. ⟨10.1126/science.adr8536⟩.
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2025Sedentary chromosomal integrons as biobanks of bacterial antiphage defense systems., Science, 2025 May; 388(6747): eads0768.
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2025Evolutionary origins of archaeal and eukaryotic RNA-guided RNA modification in bacterial IS110 transposons., Nat Microbiol 2025 Jan; (): .
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2025Strain phylogroup and environmental constraints shape Escherichia coli dynamics and diversity over a 20-year human gut time series, The International Society of Microbiologial Ecology Journal, 2025, 19 (1), ⟨10.1093/ismejo/wrae245⟩.
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2024Exploring the diversity of anti-defense systems across prokaryotes, phages and mobile genetic elements., Nucleic Acids Res 2024 Dec; (): .
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2024Prediction of strain level phage-host interactions across the Escherichia genus using only genomic information., Nat Microbiol 2024 Nov; 9(11): 2847-2861.
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2024Conservation of antiviral systems across domains of life reveals immune genes in humans, Cell Host & Microbe, 2024, 32 (9), pp.1594-1607.e5. ⟨10.1016/j.chom.2024.08.002⟩.
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2024A virally encoded tRNA neutralizes the PARIS antiviral defence system, Nature, 2024, 634 (8033), pp.424-431. ⟨10.1038/s41586-024-07874-3⟩.
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2024Viperin immunity evolved across the tree of life through serial innovations on a conserved scaffold, Nature Ecology & Evolution, 2024, 8 (9), pp.667-1679. ⟨10.1038/s41559-024-02463-z⟩.
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2024The immune modules conserved across the tree of life: Towards a definition of ancestral immunity., PLoS Biol 2024 Jul; 22(7): e3002717.
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+Voir la liste complète de publications




