Timeline

Simon Wain-Hobson
Head of Structure
12 Feb 2016
project

Group for AIDS Research

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11 May 2015
team

Molecular Retrovirology

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14 Oct 2014
publication

An avian H7N1 gain-of-function experiment of great concern

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09 Oct 2014
publication

A prevalent cancer susceptibility APOBEC3A hybrid allele bearing APOBEC3B 3’UTR enhances chromosomal DNA damage

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09 Oct 2014
publication

APOBEC3A catabolism of electroporated plasmid DNA in mouse muscle

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16 Jul 2014
publication

The Irrationality of GOF Avian Influenza Virus Research

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01 Apr 2014
publication

Erroneous identification of APOBEC3-edited chromosomal DNA in cancer genomics

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25 Oct 2013
publication

Orthologous mammalian APOBEC3A cytidine deaminases hypermutate nuclear DNA

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24 Oct 2013
publication

Pandemic influenza viruses: time to recognize our inability to predict the unpredictable and stop dangerous gain-of-function experiments

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18 Oct 2013
publication

Gain-of-function research: unknown risks

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20 Aug 2013
publication

Human APOBEC3A isoforms translocate to the nucleus and induce DNA double strand breaks leading to cell stress and death

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20 Jun 2013
publication

Efficient deamination of 5-methylcytidine and 5-substituted cytidine residues in DNA by human APOBEC3A cytidine deaminase

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28 Mar 2013
publication

H5N1 viral-engineering dangers will not go away

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28 Dec 2012
publication

Polymorphic APOBEC3 modulates chronic hepatitis B in Moroccan population

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02 Oct 2012
publication

Universal cancer peptide-based therapeutic vaccine breaks tolerance against telomerase and eradicates established tumor

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19 Sep 2012
publication

Hyperediting of human T-cell leukemia virus type 2 and simian T-cell leukemia virus type 3 by the dsRNA adenosine deaminase ADAR-1

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13 Sep 2012
publication

Human Tribbles 3 protects nuclear DNA from cytidine deamination by APOBEC3A

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06 Jun 2012
publication

Structural variability of the herpes simplex virus 1 genome in vitro and in vivo

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17 Jan 2012
publication

Evolution of the primate APOBEC3A cytidine deaminase gene and identification of related coding regions

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12 Oct 2011
publication

Research investment: Vaccine research loses out

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01 Jun 2011
publication

Genetic editing of herpes simplex virus 1 and Epstein-Barr herpesvirus genomes by human APOBEC3 cytidine deaminases in culture and in vivo

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31 Mar 2011
publication

Fitness ranking of individual mutants drives patterns of epistatic interactions in HIV-1

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02 Mar 2011
publication

Somatic hypermutation of human mitochondrial and nuclear DNA by APOBEC3 cytidine deaminases, a pathway for DNA catabolism

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15 Dec 2010
publication

Double-stranded RNA adenosine deaminase ADAR-1-induced hypermutated genomes among inactivated seasonal influenza and live attenuated measles virus vaccines

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21 Jul 2010
publication

Immunogenicity of a recombinant lentiviral vector carrying human telomerase tumor antigen in HLA-B*0702 transgenic mice

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28 May 2010
publication

APOBEC1 and APOBEC3 cytidine deaminases as restriction factors for hepadnaviral genomes in non-humans in vivo

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27 May 2010
publication

Massive APOBEC3 editing of hepatitis B viral DNA in cirrhosis

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12 May 2010
publication

APOBEC3G generates nonsense mutations in human T-cell leukemia virus type 1 proviral genomes in vivo

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03 Feb 2010
publication

Targeting human telomerase reverse transcriptase with recombinant lentivector is highly effective to stimulate antitumor CD8 T-cell immunity in vivo

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21 Oct 2009
publication

Human APOBEC1 cytidine deaminase edits HBV DNA

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17 Jun 2009
publication

Oral administration of low doses of plant-based HBsAg induced antigen-specific IgAs and IgGs in mice, without increasing levels of regulatory T cells

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12 Mar 2009
publication

Powerful mutators lurking in the genome

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26 Jan 2009
publication

Genetic editing of HBV DNA by monodomain human APOBEC3 cytidine deaminases and the recombinant nature of APOBEC3G

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01 Nov 2008
publication

Murine APOBEC1 is a powerful mutator of retroviral and cellular RNA in vitro and in vivo

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02 Jul 2008
publication

Immunogenicity and tolerance following HIV-1/HBV plant-based oral vaccine administration

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30 May 2008
publication

Inversing the natural hydrogen bonding rule to selectively amplify GC-rich ADAR-edited RNAs

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11 Apr 2008
publication

Evidence for editing of human papillomavirus DNA by APOBEC3 in benign and precancerous lesions

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14 Feb 2007
publication

Induction of mutations in Drosophila melanogaster gypsy retroelements by modulation of intracellular deoxynucleoside triphosphate pools in vivo

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08 Sep 2006
publication

Twin gradients in APOBEC3 edited HIV-1 DNA reflect the dynamics of lentiviral replication

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22 Aug 2006
publication

Optimisation of secretion of recombinant HBsAg virus-like particles: Impact on the development of HIV-1/HBV bivalent vaccines

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21 Mar 2006
publication

The HIV-1 clade C promoter is particularly well adapted to replication in the gut in primary infection

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01 Mar 2006
publication

Clade-specific differences in active viral replication and compartmentalization

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01 Jan 2006
publication

Restriction of foamy viruses by APOBEC cytidine deaminases

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01 Dec 2005
publication

The majority of human immunodeficiency virus type 1 particles present within splenic germinal centres are produced locally

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01 Sep 2005
publication

Extensive editing of a small fraction of human T-cell leukemia virus type 1 genomes by four APOBEC3 cytidine deaminases

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01 Feb 2005
publication

HIV-1 clade promoters strongly influence spatial and temporal dynamics of viral replication in vivo

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01 Jan 2005
publication

Recovery of APOBEC3-edited human immunodeficiency virus G->A hypermutants by differential DNA denaturation PCR

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15 Dec 2004
publication

A universal primer set for PCR amplification of nuclear histone H4 genes from all animal species

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30 Apr 2004
publication

APOBEC3G is a single-stranded DNA cytidine deaminase and functions independently of HIV reverse transcriptase

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01 Feb 2004
publication

Simian immunodeficiency virus promoter exchange results in a highly attenuated strain that protects against uncloned challenge virus

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01 Oct 2003
publication

Death and the retrovirus

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01 Apr 2003
publication

Network analysis of human and simian immunodeficiency virus sequence sets reveals massive recombination resulting in shorter pathways

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01 Nov 2002
publication

Identification of a hepatitis B virus genome in wild chimpanzees (Pan troglodytes schweinfurthi) from East Africa indicates a wide geographical dispersion among equatorial African primates

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28 May 2002
publication

Analysis of a library of macaque nuclear mitochondrial sequences confirms macaque origin of divergent sequences from old oral polio vaccine samples

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01 Apr 2002
publication

Sustained G–>A hypermutation during reverse transcription of an entire human immunodeficiency virus type 1 strain Vau group O genome

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01 Mar 2002
publication

Phylogeny derived from coding retroviral genome organization

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