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© Research
Publication : Vaccine

Immunogenicity and tolerance following HIV-1/HBV plant-based oral vaccine administration

Team: Archived: Molecular Retrovirology
Member: Simon Wain-Hobson
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Vaccine - 02 Jul 2008

Guetard D, Greco R, Cervantes Gonzalez M, Celli S, Kostrzak A, Langlade-Demoyen P, Sala F, Wain-Hobson S, Sala M

Link to Pubmed [PMID] – 18601967

Vaccine 2008 Aug;26(35):4477-85

Transgenic tobacco plants expressing a HIV-1 polyepitope associated with hepatitis B (HBV) virus-like particles (VLPs) were previously described. It is demonstrated here that oral administration of these transgenic plants to humanized HSB mice to boost DNA-priming can elicit anti-HIV-1 specific CD8+ T cell activation detectable in mesenteric lymph nodes. Nevertheless, a significant regulatory T cell activation was induced in vivo by the vaccination protocols. The balance between tolerance and immunogenicity remains the main concern in the proof of concept of plant-based vaccine.