Timeline

Sophie Vichier-Guerre

Permanent Researcher

16 May 2024

publication

Dynamic microfluidic single-cell screening identifies pheno-tuning compounds to potentiate tuberculosis therapy

16 May 2024

publication

Dynamic microfluidic single-cell screening identifies pheno-tuning compounds to potentiate tuberculosis therapy

18 Apr 2024

publication

Adenine, a key player in biology and medicinal chemistry

07 Feb 2023

publication

Interaction network among de novo purine nucleotide biosynthesis enzymes in Escherichia coli.

01 Jun 2022

publication

Identification of Chemical Probes Targeting MBD2.

22 Feb 2020

publication

Fermentation Products of Commensal Bacteria Alter Enterocyte Lipid Metabolism

03 Jan 2020

publication

An expedient synthesis of flexible nucleosides through enzymatic glycosylation of proximal and distal fleximer bases

20 Jun 2019

publication

Crystal structure of the Trypanosoma cruzi EIF4E5 translation factor homologue in complex with mRNA cap-4

02 Feb 2019

publication

First-in-class allosteric inhibitors of bacterial IMPDHs

02 Jan 2019

publication

2′-Deoxyribonucleoside 5′-triphosphates bearing 4-phenyl and 4-pyrimidinyl imidazoles as DNA polymerase substrates

09 Mar 2018

project

Protein synthesis machinery of Trypanosomatid as a therapeutic target

09 Jan 2018

team

Epigenetic Chemical Biology

12 Sep 2017

publication

An expedient synthesis of flexible nucleosides via a regiocontrolled enzymatic glycosylation of functionalized imidazoles

11 Mar 2016

publication

Expedient and generic synthesis of imidazole nucleosides by enzymatic transglycosylation

03 Sep 2015

project

Inhibitors of Pseudomonas aeruginosa IMPDH

12 Nov 2014

publication

A convenient synthesis of 4(5)-(hetero)aryl-1H-imidazoles via microwave-assisted Suzuki-Miyaura cross-coupling reaction

01 Sep 2010

publication

Characterisation of a DNA polymerase highly mutated along the template binding interface

18 Aug 2010

publication

Glycosidic Tn-based vaccines targeting dermal dendritic cells favor germinal center B-cell development and potent antibody response in the absence of adjuvant

01 Dec 2006

publication

Carbohydrate antigens: synthesis aspects and immunological applications in cancer

18 Sep 2006

publication

A population of thermostable reverse transcriptases evolved from Thermus aquaticus DNA polymerase I by phage display

18 Oct 2005

publication

How to broaden enzyme substrate specificity: strategies, implications and applications

01 Jul 2004

publication

Synthesis and immunological evaluation of an antitumor neoglycopeptide vaccine bearing a novel homoserine Tn antigen

01 Sep 2003

publication

Induction of carbohydrate-specific antibodies in HLA-DR transgenic mice by a synthetic glycopeptide: a potential anti cancer vaccine for human use

14 Apr 2003

publication

Iterative cycles of in vitro protein selection for DNA polymerase activity

15 Feb 2001

publication

Anti-tumor immunity provided by a synthetic multiple antigenic glycopeptide displaying a tri-Tn glycotope

01 Feb 2001

publication

High density O-glycosylation of the MUC2 tandem repeat unit by N-acetylgalactosaminyltransferase-3 in colonic adenocarcinoma extracts

01 Feb 2000

publication

Short synthetic glycopeptides successfully induce antibody responses to carcinoma-associated Tn antigen

01 Apr 1999

publication

A fully synthetic immunogen carrying a carcinoma-associated carbohydrate for active specific immunotherapy

09 Jul 1998

publication

Selective mRNA degradation by antisense oligonucleotide-2,5A chimeras: Involvement of RNase H and RNase L

04 Apr 1997

publication

Stereoisomers of Deoxynucleoside 5′-Triphosphates as Substrates for Template-dependent and -independent DNA Polymerases

01 Jan 1994

publication

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Timeline

Dynamic microfluidic single-cell screening identifies pheno-tuning compounds to potentiate tuberculosis therapy

Dynamic microfluidic single-cell screening identifies pheno-tuning compounds to potentiate tuberculosis therapy

Adenine, a key player in biology and medicinal chemistry

Interaction network among de novo purine nucleotide biosynthesis enzymes in Escherichia coli.

Identification of Chemical Probes Targeting MBD2.

Fermentation Products of Commensal Bacteria Alter Enterocyte Lipid Metabolism

An expedient synthesis of flexible nucleosides through enzymatic glycosylation of proximal and distal fleximer bases

Crystal structure of the Trypanosoma cruzi EIF4E5 translation factor homologue in complex with mRNA cap-4

First-in-class allosteric inhibitors of bacterial IMPDHs

2′-Deoxyribonucleoside 5′-triphosphates bearing 4-phenyl and 4-pyrimidinyl imidazoles as DNA polymerase substrates

Protein synthesis machinery of Trypanosomatid as a therapeutic target

Epigenetic Chemical Biology

An expedient synthesis of flexible nucleosides via a regiocontrolled enzymatic glycosylation of functionalized imidazoles

Expedient and generic synthesis of imidazole nucleosides by enzymatic transglycosylation

Inhibitors of Pseudomonas aeruginosa IMPDH

A convenient synthesis of 4(5)-(hetero)aryl-1H-imidazoles via microwave-assisted Suzuki-Miyaura cross-coupling reaction

Characterisation of a DNA polymerase highly mutated along the template binding interface

Glycosidic Tn-based vaccines targeting dermal dendritic cells favor germinal center B-cell development and potent antibody response in the absence of adjuvant

Carbohydrate antigens: synthesis aspects and immunological applications in cancer

A population of thermostable reverse transcriptases evolved from Thermus aquaticus DNA polymerase I by phage display

How to broaden enzyme substrate specificity: strategies, implications and applications

Synthesis and immunological evaluation of an antitumor neoglycopeptide vaccine bearing a novel homoserine Tn antigen

Induction of carbohydrate-specific antibodies in HLA-DR transgenic mice by a synthetic glycopeptide: a potential anti cancer vaccine for human use

Iterative cycles of in vitro protein selection for DNA polymerase activity

Anti-tumor immunity provided by a synthetic multiple antigenic glycopeptide displaying a tri-Tn glycotope

High density O-glycosylation of the MUC2 tandem repeat unit by N-acetylgalactosaminyltransferase-3 in colonic adenocarcinoma extracts

Short synthetic glycopeptides successfully induce antibody responses to carcinoma-associated Tn antigen

A fully synthetic immunogen carrying a carcinoma-associated carbohydrate for active specific immunotherapy

Selective mRNA degradation by antisense oligonucleotide-2,5A chimeras: Involvement of RNase H and RNase L

Stereoisomers of Deoxynucleoside 5′-Triphosphates as Substrates for Template-dependent and -independent DNA Polymerases

New Insights into the Resistance of α-Oligonucleotides to Nucleases