Timeline

Frédérique Michel
Group Leader
01 Apr 2023
publication

Central Role of Macrophages and Nucleic Acid Release in Myasthenia Gravis Thymus.

Read more
19 Jan 2022
project

Signatures microARNs cellulaires dans la sclérose en plaques -SEP-MIR

Read more
01 Jan 2022
publication

IFN-I inducible miR-3614-5p targets ADAR1 isoforms and fine tunes innate immune activation.

Read more
01 Jan 2021
publication

Altered Immune Phenotypes and HLA-DQB1 Gene Variation in Multiple Sclerosis Patients Failing Interferon β Treatment.

Read more
20 Feb 2020
event

Department of Immunology seminar: Roberto Mallone, Benign islet autoimmunity and type 1 diabetes: lessons from CD8+ T cells

Read more
01 Jan 2020
publication

Two common disease-associated TYK2 variants impact exon splicing and TYK2 dosage.

Read more
01 Jan 2020
publication

Human Ubiquitin-Specific Peptidase 18 Is Regulated by microRNAs via the 3’Untranslated Region, A Sequence Duplicated in Long Intergenic Non-coding RNA Genes Residing in chr22q11.21.

Read more
08 May 2019
publication

Expression of endogenous retroviruses reflects increased usage of atypical enhancers in T cells

Read more
27 Feb 2017
publication

Type I interferon-enhanced IL-10 expression in human CD4 T cells is regulated by STAT3, STAT2, and BATF transcription factors

Read more
15 Sep 2015
project

TYK2 variants in cytokine signaling and autoimmune diseases

Read more
14 Sep 2015
project

Cellular and molecular immunoprofiling of multiple sclerosis patients

Read more
14 Sep 2015
project

Role of IFN-I in the development of IL-10-producing CD4 T cells

Read more
15 Jul 2013
publication

Type I interferon potentiates T-cell receptor mediated induction of IL-10-producing CD4⁺ T cells

Read more
28 Jan 2013
publication

Two rare disease-associated Tyk2 variants are catalytically impaired but signaling competent.

Read more
29 Jun 2012
publication

A conserved polylysine motif in CD86 cytoplasmic tail is necessary for cytoskeletal association and effective co-stimulation.

Read more
30 Nov 2010
publication

T cell receptor signal initiation induced by low-grade stimulation requires the cooperation of LAT in human T cells

Read more
01 Sep 2008
publication

Tailoring T-cell receptor signals by proximal negative feedback mechanisms.

Read more
01 Aug 2007
publication

The JNK/AP-1 pathway upregulates expression of the recycling endosome rab11a gene in B cells transformed by Theileria.

Read more
19 Mar 2007
publication

A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76.

Read more
16 Oct 2006
publication

T cell receptor for antigen induces linker for activation of T cell-dependent activation of a negative signaling complex involving Dok-2, SHIP-1, and Grb-2

Read more
01 Apr 2006
publication

Role of Fyn in the rearrangement of tubulin cytoskeleton induced through TCR.

Read more
01 Apr 2006
publication

Costimulatory receptors in a teleost fish: typical CD28, elusive CTLA4.

Read more
25 Aug 2005
publication

Direct recognition by alphabeta cytolytic T cells of Hfe, a MHC class Ib molecule without antigen-presenting function

Read more
01 Jun 2004
publication

Cognate MHC-TCR interaction leads to apoptosis of antigen-presenting cells.

Read more
01 Dec 2003
publication

CD28-mediated co-stimulation: a quantitative support for TCR signalling

Read more
01 Apr 2003
publication

Molecular modifiers of T cell antigen receptor triggering threshold: the mechanism of CD28 costimulatory receptor.

Read more
23 Dec 2002
publication

CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling

Read more
15 Oct 2002
publication

Engagement of the inhibitory receptor CD158a interrupts TCR signaling, preventing dynamic membrane reorganization in CTL/tumor cell interaction.

Read more
06 Aug 2002
publication

CD28 costimulation: a source of Vav-1 for TCR signaling with the help of SLP-76?

Read more
01 Feb 2002
publication

Vav cooperates with CD28 to induce NF-kappaB activation via a pathway involving Rac-1 and mitogen-activated kinase kinase 1.

Read more
01 Dec 2001
publication

CD28 as a molecular amplifier extending TCR ligation and signaling capabilities.

Read more
01 Nov 2001
publication

The membrane-microfilament linker ezrin is involved in the formation of the immunological synapse and in T cell activation.

Read more
01 Aug 2001
publication

An absolute requirement for Fyn in T cell receptor-induced caspase activation and apoptosis.

Read more
01 May 2001
publication

Differential roles of Lck and Itk in T cell response to antigen recognition revealed by calcium imaging and electron microscopy.

Read more
01 Oct 2000
publication

CD28 utilizes Vav-1 to enhance TCR-proximal signaling and NF-AT activation.

Read more
27 Jul 2000
publication

Increased protein synthesis after T cell activation in presence of cyclosporin A.

Read more
15 Jun 1999
publication

Fyn membrane localization is necessary to induce the constitutive tyrosine phosphorylation of Sam68 in the nucleus of T lymphocytes.

Read more
05 Mar 1999
publication

Tyrosine 319, a newly identified phosphorylation site of ZAP-70, plays a critical role in T cell antigen receptor signaling.

Read more
27 Nov 1998
publication

Fyn and ZAP-70 are required for Vav phosphorylation in T cells stimulated by antigen-presenting cells.

Read more
01 Nov 1997
publication

Enrichment of antigen-specific T lymphocytes by panning on immobilized MHC-peptide complexes.

Read more
15 Apr 1997
publication

Molecular characterization and role in T cell activation of staphylococcal enterotoxin A binding to the HLA-DR alpha-chain.

Read more
20 Dec 1996
publication

Mutation of tyrosines 492/493 in the kinase domain of ZAP-70 affects multiple T-cell receptor signaling pathways.

Read more
01 Nov 1996
publication

Induction of T cell adhesion by antigen stimulation and modulation by the coreceptor CD4.

Read more
01 Sep 1996
publication

p95vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells.

Read more
15 Apr 1993
publication

Defective calcium response in B-chronic lymphocytic leukemia cells. Alteration of early protein tyrosine phosphorylation and of the mechanism responsible for cell calcium influx.

Read more
01 Apr 1992
publication

HIV-1 env, nef, and gag-specific T-cell immunity in mice: conserved epitopes in nef p27 and gag p25 proteins.

Read more
01 Jan 1992
publication

Enhancement of HIV-specific cytotoxic T lymphocyte responses by zidovudine (AZT) treatment.

Read more
01 Sep 1989
publication

Multiple subsets of HIV-specific cytotoxic T lymphocytes in humans and in mice.

Read more
15 Jan 1989
publication

Unusually high frequencies of HIV-specific cytotoxic T lymphocytes in humans.

Read more
01 Jan 1989
publication

Cytotoxic T lymphocytes in HIV-induced disease: implications for therapy and vaccination.

Read more
01 Dec 1988
publication

HIV-specific T lymphocyte immunity in mice immunized with a recombinant vaccinia virus.

Read more
15 Sep 1988
publication

Immune recognition of AIDS virus antigens by human and murine cytotoxic T lymphocytes.

Read more
01 Jun 1987
publication

Enhancement of bronchoalveolar cell recovery and stimulation of alveolar macrophage chemiluminescence and resistance to influenza virus after treatment with RU 41821 aerosol.

Read more
01 Jan 1987
publication

Effects of RU 41740 aerosol treatment on mouse bronchoalveolar cells, and protection afforded against influenza virus infection.

Read more