Timeline

Frédérique Michel

Group Leader

01 Apr 2023

publication

Central Role of Macrophages and Nucleic Acid Release in Myasthenia Gravis Thymus.

19 Jan 2022

project

Signatures microARNs cellulaires dans la sclérose en plaques -SEP-MIR

01 Jan 2022

publication

IFN-I inducible miR-3614-5p targets ADAR1 isoforms and fine tunes innate immune activation.

01 Jan 2021

publication

Altered Immune Phenotypes and HLA-DQB1 Gene Variation in Multiple Sclerosis Patients Failing Interferon β Treatment.

20 Feb 2020

event

Department of Immunology seminar: Roberto Mallone, Benign islet autoimmunity and type 1 diabetes: lessons from CD8+ T cells

01 Jan 2020

publication

Two common disease-associated TYK2 variants impact exon splicing and TYK2 dosage.

01 Jan 2020

publication

Human Ubiquitin-Specific Peptidase 18 Is Regulated by microRNAs via the 3’Untranslated Region, A Sequence Duplicated in Long Intergenic Non-coding RNA Genes Residing in chr22q11.21.

08 May 2019

publication

Expression of endogenous retroviruses reflects increased usage of atypical enhancers in T cells

27 Feb 2017

publication

Type I interferon-enhanced IL-10 expression in human CD4 T cells is regulated by STAT3, STAT2, and BATF transcription factors

15 Sep 2015

project

TYK2 variants in cytokine signaling and autoimmune diseases

14 Sep 2015

project

Cellular and molecular immunoprofiling of multiple sclerosis patients

14 Sep 2015

project

Role of IFN-I in the development of IL-10-producing CD4 T cells

15 Jul 2013

publication

Type I interferon potentiates T-cell receptor mediated induction of IL-10-producing CD4⁺ T cells

28 Jan 2013

publication

Two rare disease-associated Tyk2 variants are catalytically impaired but signaling competent.

29 Jun 2012

publication

A conserved polylysine motif in CD86 cytoplasmic tail is necessary for cytoskeletal association and effective co-stimulation.

30 Nov 2010

publication

T cell receptor signal initiation induced by low-grade stimulation requires the cooperation of LAT in human T cells

01 Sep 2008

publication

Tailoring T-cell receptor signals by proximal negative feedback mechanisms.

01 Aug 2007

publication

The JNK/AP-1 pathway upregulates expression of the recycling endosome rab11a gene in B cells transformed by Theileria.

19 Mar 2007

publication

A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76.

16 Oct 2006

publication

T cell receptor for antigen induces linker for activation of T cell-dependent activation of a negative signaling complex involving Dok-2, SHIP-1, and Grb-2

01 Apr 2006

publication

Role of Fyn in the rearrangement of tubulin cytoskeleton induced through TCR.

01 Apr 2006

publication

Costimulatory receptors in a teleost fish: typical CD28, elusive CTLA4.

25 Aug 2005

publication

Direct recognition by alphabeta cytolytic T cells of Hfe, a MHC class Ib molecule without antigen-presenting function

01 Jun 2004

publication

Cognate MHC-TCR interaction leads to apoptosis of antigen-presenting cells.

01 Dec 2003

publication

CD28-mediated co-stimulation: a quantitative support for TCR signalling

01 Apr 2003

publication

Molecular modifiers of T cell antigen receptor triggering threshold: the mechanism of CD28 costimulatory receptor.

23 Dec 2002

publication

CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling

15 Oct 2002

publication

Engagement of the inhibitory receptor CD158a interrupts TCR signaling, preventing dynamic membrane reorganization in CTL/tumor cell interaction.

06 Aug 2002

publication

CD28 costimulation: a source of Vav-1 for TCR signaling with the help of SLP-76?

01 Feb 2002

publication

Vav cooperates with CD28 to induce NF-kappaB activation via a pathway involving Rac-1 and mitogen-activated kinase kinase 1.

01 Dec 2001

publication

CD28 as a molecular amplifier extending TCR ligation and signaling capabilities.

01 Nov 2001

publication

The membrane-microfilament linker ezrin is involved in the formation of the immunological synapse and in T cell activation.

01 Aug 2001

publication

An absolute requirement for Fyn in T cell receptor-induced caspase activation and apoptosis.

01 May 2001

publication

Differential roles of Lck and Itk in T cell response to antigen recognition revealed by calcium imaging and electron microscopy.

01 Oct 2000

publication

CD28 utilizes Vav-1 to enhance TCR-proximal signaling and NF-AT activation.

27 Jul 2000

publication

Increased protein synthesis after T cell activation in presence of cyclosporin A.

15 Jun 1999

publication

Fyn membrane localization is necessary to induce the constitutive tyrosine phosphorylation of Sam68 in the nucleus of T lymphocytes.

05 Mar 1999

publication

Tyrosine 319, a newly identified phosphorylation site of ZAP-70, plays a critical role in T cell antigen receptor signaling.

27 Nov 1998

publication

Fyn and ZAP-70 are required for Vav phosphorylation in T cells stimulated by antigen-presenting cells.

01 Nov 1997

publication

Enrichment of antigen-specific T lymphocytes by panning on immobilized MHC-peptide complexes.

15 Apr 1997

publication

Molecular characterization and role in T cell activation of staphylococcal enterotoxin A binding to the HLA-DR alpha-chain.

20 Dec 1996

publication

Mutation of tyrosines 492/493 in the kinase domain of ZAP-70 affects multiple T-cell receptor signaling pathways.

01 Nov 1996

publication

Induction of T cell adhesion by antigen stimulation and modulation by the coreceptor CD4.

01 Sep 1996

publication

p95vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells.

15 Apr 1993

publication

Defective calcium response in B-chronic lymphocytic leukemia cells. Alteration of early protein tyrosine phosphorylation and of the mechanism responsible for cell calcium influx.

01 Apr 1992

publication

HIV-1 env, nef, and gag-specific T-cell immunity in mice: conserved epitopes in nef p27 and gag p25 proteins.

01 Jan 1992

publication

Enhancement of HIV-specific cytotoxic T lymphocyte responses by zidovudine (AZT) treatment.

01 Sep 1989

publication

Multiple subsets of HIV-specific cytotoxic T lymphocytes in humans and in mice.

15 Jan 1989

publication

Unusually high frequencies of HIV-specific cytotoxic T lymphocytes in humans.

01 Jan 1989

publication

Cytotoxic T lymphocytes in HIV-induced disease: implications for therapy and vaccination.

01 Dec 1988

publication

HIV-specific T lymphocyte immunity in mice immunized with a recombinant vaccinia virus.

15 Sep 1988

publication

Immune recognition of AIDS virus antigens by human and murine cytotoxic T lymphocytes.

01 Jun 1987

publication

Enhancement of bronchoalveolar cell recovery and stimulation of alveolar macrophage chemiluminescence and resistance to influenza virus after treatment with RU 41821 aerosol.

01 Jan 1987

publication

A little guide for advanced search:

Central Role of Macrophages and Nucleic Acid Release in Myasthenia Gravis Thymus.

Signatures microARNs cellulaires dans la sclérose en plaques -SEP-MIR

IFN-I inducible miR-3614-5p targets ADAR1 isoforms and fine tunes innate immune activation.

Altered Immune Phenotypes and HLA-DQB1 Gene Variation in Multiple Sclerosis Patients Failing Interferon β Treatment.

Department of Immunology seminar: Roberto Mallone, Benign islet autoimmunity and type 1 diabetes: lessons from CD8+ T cells

Two common disease-associated TYK2 variants impact exon splicing and TYK2 dosage.

Human Ubiquitin-Specific Peptidase 18 Is Regulated by microRNAs via the 3’Untranslated Region, A Sequence Duplicated in Long Intergenic Non-coding RNA Genes Residing in chr22q11.21.

Expression of endogenous retroviruses reflects increased usage of atypical enhancers in T cells

Type I interferon-enhanced IL-10 expression in human CD4 T cells is regulated by STAT3, STAT2, and BATF transcription factors

TYK2 variants in cytokine signaling and autoimmune diseases

Cellular and molecular immunoprofiling of multiple sclerosis patients

Role of IFN-I in the development of IL-10-producing CD4 T cells

Type I interferon potentiates T-cell receptor mediated induction of IL-10-producing CD4⁺ T cells

Two rare disease-associated Tyk2 variants are catalytically impaired but signaling competent.

A conserved polylysine motif in CD86 cytoplasmic tail is necessary for cytoskeletal association and effective co-stimulation.

T cell receptor signal initiation induced by low-grade stimulation requires the cooperation of LAT in human T cells

Tailoring T-cell receptor signals by proximal negative feedback mechanisms.

The JNK/AP-1 pathway upregulates expression of the recycling endosome rab11a gene in B cells transformed by Theileria.

A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76.

T cell receptor for antigen induces linker for activation of T cell-dependent activation of a negative signaling complex involving Dok-2, SHIP-1, and Grb-2

Role of Fyn in the rearrangement of tubulin cytoskeleton induced through TCR.

Costimulatory receptors in a teleost fish: typical CD28, elusive CTLA4.

Direct recognition by alphabeta cytolytic T cells of Hfe, a MHC class Ib molecule without antigen-presenting function

Cognate MHC-TCR interaction leads to apoptosis of antigen-presenting cells.

CD28-mediated co-stimulation: a quantitative support for TCR signalling

Molecular modifiers of T cell antigen receptor triggering threshold: the mechanism of CD28 costimulatory receptor.

CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling

Engagement of the inhibitory receptor CD158a interrupts TCR signaling, preventing dynamic membrane reorganization in CTL/tumor cell interaction.

CD28 costimulation: a source of Vav-1 for TCR signaling with the help of SLP-76?

Vav cooperates with CD28 to induce NF-kappaB activation via a pathway involving Rac-1 and mitogen-activated kinase kinase 1.

CD28 as a molecular amplifier extending TCR ligation and signaling capabilities.

The membrane-microfilament linker ezrin is involved in the formation of the immunological synapse and in T cell activation.

An absolute requirement for Fyn in T cell receptor-induced caspase activation and apoptosis.

Differential roles of Lck and Itk in T cell response to antigen recognition revealed by calcium imaging and electron microscopy.

CD28 utilizes Vav-1 to enhance TCR-proximal signaling and NF-AT activation.

Increased protein synthesis after T cell activation in presence of cyclosporin A.

Fyn membrane localization is necessary to induce the constitutive tyrosine phosphorylation of Sam68 in the nucleus of T lymphocytes.

Tyrosine 319, a newly identified phosphorylation site of ZAP-70, plays a critical role in T cell antigen receptor signaling.

Fyn and ZAP-70 are required for Vav phosphorylation in T cells stimulated by antigen-presenting cells.

Enrichment of antigen-specific T lymphocytes by panning on immobilized MHC-peptide complexes.

Molecular characterization and role in T cell activation of staphylococcal enterotoxin A binding to the HLA-DR alpha-chain.

Mutation of tyrosines 492/493 in the kinase domain of ZAP-70 affects multiple T-cell receptor signaling pathways.

Induction of T cell adhesion by antigen stimulation and modulation by the coreceptor CD4.

p95vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells.

Defective calcium response in B-chronic lymphocytic leukemia cells. Alteration of early protein tyrosine phosphorylation and of the mechanism responsible for cell calcium influx.

HIV-1 env, nef, and gag-specific T-cell immunity in mice: conserved epitopes in nef p27 and gag p25 proteins.

Enhancement of HIV-specific cytotoxic T lymphocyte responses by zidovudine (AZT) treatment.

Multiple subsets of HIV-specific cytotoxic T lymphocytes in humans and in mice.

Unusually high frequencies of HIV-specific cytotoxic T lymphocytes in humans.

Cytotoxic T lymphocytes in HIV-induced disease: implications for therapy and vaccination.

HIV-specific T lymphocyte immunity in mice immunized with a recombinant vaccinia virus.

Immune recognition of AIDS virus antigens by human and murine cytotoxic T lymphocytes.

Enhancement of bronchoalveolar cell recovery and stimulation of alveolar macrophage chemiluminescence and resistance to influenza virus after treatment with RU 41821 aerosol.

Effects of RU 41740 aerosol treatment on mouse bronchoalveolar cells, and protection afforded against influenza virus infection.