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© Research
Publication : Nature immunology

CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature immunology - 23 Dec 2002

Irles C, Symons A, Michel F, Bakker TR, van der Merwe PA, Acuto O

Link to Pubmed [PMID] – 12496963

Nat. Immunol. 2003 Feb;4(2):189-97

The transmembrane phosphatase CD45 regulates both Lck activity and T cell receptor (TCR) signaling. Here we have tested whether the large ectodomain of CD45 has a role in this regulation. A CD45 chimera containing the large ectodomain of CD43 efficiently rescues TCR signaling in CD45-null T cells, whereas CD45 chimeras containing small ectodomains from other phosphatases do not. Both basal Lck activity in unstimulated cells and the TCR-induced increase in tyrosine phosphorylation of the TCR zeta-chain and in Lck activity depend on the expression of CD45 with a large ectodomain. Unlike CD45 chimeras containing small ectodomains, both the CD45 chimera with a large ectodomain and wild-type CD45 itself are partially localized to glycosphingolipid-enriched membranes (GEMs). Taken together, these data show that the large CD45 ectodomain is required for optimal TCR signaling.

http://www.ncbi.nlm.nih.gov/pubmed/12496963