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© Research
Publication : Science's STKE : signal transduction knowledge environment

CD28 costimulation: a source of Vav-1 for TCR signaling with the help of SLP-76?

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Science's STKE : signal transduction knowledge environment - 06 Aug 2002

Michel F, Acuto O

Link to Pubmed [PMID] – 12165654

Sci. STKE 2002 Aug;2002(144):pe35

T cells require dual stimulation to become activated. When T cells encounter antigen-presenting cells, both the T cell receptor (TCR) and the CD28 coreceptor are ligated and activated. Michel and Acuto discuss how the adaptor SLP-76, which is recruited to the activated TCR complex, and the Rho family guanosine triphosphatase exchanger Vav-1, which is recruited by the CD28 receptor and TCR, may form a macromolecular complex that results in T cells activation. Vav-1 may serve as a central integrator between CD28 signaling and TCR signaling through its indirect effects on phosphoinositide 3-kinase-dependent signaling.

http://www.ncbi.nlm.nih.gov/pubmed/12165654