Timeline

Eliane Meurs
Permanent Researcher
23 Nov 2017
publication

Inhibition of the inflammatory response to stress by targeting interaction between PKR and its cellular activator PACT

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17 Jun 2016
news

VIROLOGY DEPARTMENT SEMINAR

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17 Sep 2015
project

Interferon induction, inflammation and stress in HCV infection and stress-related pathologies

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23 Jul 2015
project

Interaction of HCV with the IFN and stress pathways

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03 Jul 2015
project

Chronic infections with Hepatitis C (HCV) and Hepatitis B (HBV) viruses

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11 May 2015
team

Viral Genomics and Vaccination

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01 May 2015
publication

Increased levels of cerebrospinal fluid JNK3 associated with amyloid pathology: links to cognitive decline

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23 Jul 2014
publication

HIV-1 translation and its regulation by cellular factors PKR and PACT

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29 Oct 2012
publication

dsRNA-dependent protein kinase PKR and its role in stress, signaling and HCV infection

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13 Oct 2011
publication

Hepatitis C virus reveals a novel early control in acute immune response

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11 May 2010
publication

Hepatitis C virus controls interferon production through PKR activation

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01 Jan 2010
publication

ER targeting and retention of the HCV NS4B protein relies on the concerted action of multiple structural features including its transmembrane domains

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22 Jun 2009
publication

Polo-like kinase 1 (PLK1) regulates interferon (IFN) induction by MAVS

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21 May 2007
publication

Lipoprotein lipase mediates hepatitis C virus (HCV) cell entry and inhibits HCV infection

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15 Mar 2007
publication

Cutting Edge: Influenza A virus activates TLR3-dependent inflammatory and RIG-I-dependent antiviral responses in human lung epithelial cells

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01 Dec 2006
publication

The protein kinase IKKepsilon can inhibit HCV expression independently of IFN and its own expression is downregulated in HCV-infected livers

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01 Dec 2006
publication

A hepatitis C virus (HCV) NS3/4A protease-dependent strategy for the identification and purification of HCV-infected cells

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28 Feb 2006
publication

The N-terminus of PKR is responsible for the activation of the NF-kappaB signaling pathway by interacting with the IKK complex

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01 Apr 2005
publication

Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilon

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17 Mar 2004
publication

Positive effect of the hepatitis C virus nonstructural 5A protein on viral multiplication

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09 Dec 2002
publication

The TAR RNA-binding protein, TRBP, stimulates the expression of TAR-containing RNAs in vitro and in vivo independently of its ability to inhibit the dsRNA-dependent kinase PKR

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15 Oct 2002
publication

The role of the phosphorus BI-BII transition in protein-DNA recognition: the NF-kappaB complex

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14 Feb 2002
publication

Variability of the nonstructural 5A protein of hepatitis C virus type 3a isolates and relation to interferon sensitivity

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03 Jul 2001
publication

Two dimerization domains in the trans-activation response RNA-binding protein (TRBP) individually reverse the protein kinase R inhibition of HIV-1 long terminal repeat expression

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01 Oct 2000
publication

1H-13C nuclear magnetic resonance assignment and structural characterization of HIV-1 Tat protein

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01 Jul 2000
publication

PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex

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01 Jun 2000
publication

Expression of hepatitis C virus proteins interferes with the antiviral action of interferon independently of PKR-mediated control of protein synthesis

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01 Jan 2000
publication

Activation of p38 mitogen-activated protein kinase and c-Jun NH(2)-terminal kinase by double-stranded RNA and encephalomyocarditis virus: involvement of RNase L, protein kinase R, and alternative pathways

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23 Apr 1999
publication

Full peptide synthesis, purification, and characterization of six Tat variants. Differences observed between HIV-1 isolates from Africa and other continents

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11 Oct 1996
publication

Double-stranded RNA-dependent protein kinase mediates c-Myc suppression induced by type I interferons

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20 Dec 1995
publication

Human PKR transfected into murine cells stimulates expression of genes under control of the HIV1 or HTLV-I LTR

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21 Jul 1995
publication

Molecular mechanisms responsible for malignant transformation by regulatory and catalytic domain variants of the interferon-induced enzyme RNA-dependent protein kinase

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01 May 1995
publication

Nuclear localization of the interferon-inducible protein kinase PKR in human cells and transfected mouse cells

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01 Oct 1994
publication

Characterization of an interferon-induced 48-kD protein immunologically related to the double-stranded RNA-activated protein kinase PKR

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15 Nov 1993
publication

Molecular cloning of two new interferon-induced, highly related nuclear phosphoproteins

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01 Jun 1993
publication

Localization of the human interferon-induced, ds-RNA activated p68 kinase gene (PRKR) to chromosome 2p21-p22

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01 Jan 1993
publication

Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase

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01 Dec 1992
publication

Detection of protein kinase homologues and viral RNA-binding domains utilizing polyclonal antiserum prepared against a baculovirus-expressed ds RNA-activated 68,000-Da protein kinase

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01 Oct 1992
publication

Constitutive expression of human double-stranded RNA-activated p68 kinase in murine cells mediates phosphorylation of eukaryotic initiation factor 2 and partial resistance to encephalomyocarditis virus growth

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01 Apr 1992
publication

Human p68 kinase exhibits growth suppression in yeast and homology to the translational regulator GCN2

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01 Nov 1991
publication

Functional expression and RNA binding analysis of the interferon-induced, double-stranded RNA-activated, 68,000-Mr protein kinase in a cell-free system

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22 Oct 1991
publication

Functional expression and characterization of the interferon-induced double-stranded RNA activated P68 protein kinase from Escherichia coli

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27 Jul 1990
publication

Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon

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01 Jun 1988
publication

Alpha-interferon inhibits the expression of heavy chain mu messenger RNA in Daudi cells

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01 Jul 1987
publication

Rapid decrease in the levels of the double-stranded RNA-dependent protein kinase during virus infections

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01 Jan 1985
publication

The 2-5A system in control and interferon-treated K/BALB cells infected with encephalomyocarditis virus

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01 Jan 1984
publication

Purification of the major species of human leucocyte interferon with the help of a monoclonal antibody

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01 Sep 1982
publication

Use of an anti-human leukocyte interferon monoclonal antibody for the purification and radioimmunoassay of human alpha interferon

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01 Feb 1981
publication

Interferon-mediated antiviral state in human MRC5 cells in the absence of detectable levels of 2-5A synthetase and protein kinase

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15 Jul 1980
publication

Antiviral response and induction of specific proteins in cells treated with immune T (type II) interferon analogous to that from viral interferon (type I)-treated cells

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01 Aug 1979
publication

Prophage substitution and prophage loss from superinfected Escherichia coli recA(P1) lysogens

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01 Jul 1979
publication

Increased nuclease activity in cells treated with pppA2’p5’A2’p5′ A

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