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© Research
Publication : Genomics

Localization of the human interferon-induced, ds-RNA activated p68 kinase gene (PRKR) to chromosome 2p21-p22

Team: Archived: Hepacivirus and Innate Immunity
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Genomics - 01 Jun 1993

Squire J, Meurs EF, Chong KL, McMillan NA, Hovanessian AG, Williams BR

Link to Pubmed [PMID] – 7686884

Genomics 1993 Jun;16(3):768-70

The interferon-induced dsRNA-activated protein kinase (PRKR) belongs to a subclass of serine/threonine kinases, involved in the regulation of protein synthesis by phosphorylation of the alpha subunit of initiation factor eIF2. Somatic cell hybrids segregating human chromosomes were used to assign this kinase to human chromosome 2. Fluorescence in situ hybridization confirmed this assignment and further localized the gene (PRKR) to the boundary region of bands p21 and 22.