Gene expression profiling in germinal center B cells
Germinal centers (GC) are essential for an effective humoral immune response. The GC provides an environment that stimulates B cells to proliferate in response to antigens and accumulate somatic mutations in immunoglobulin (Ig) genes, […]
The role of a gradient of the chemokine CXCL12 in hematopoietic development and in a normal immune response. (Collaboration with F. Arenzana-Seisdedos, granted ANR funding)
Interaction with heparan sulfate proteoglycans is supposed to provide chemokines with the capacity to immobilize on cell surface and extracellular matrix for accomplishing both tissue homing and signaling of attracted cells. The laboratory of […]
Deregulation of hematopoiesis by Interleukin-10 over-expression (Joint project with the University of Minho, Portugal, granted ANR international funding)
Cytokines are soluble molecules that regulate a large array of developmental processes. In the hematopoietic system, cytokines mediate the production of mature blood cells from specific lineages, by directly acting on hematopoietic progenitors. Cytokines […]
2019Biology and therapeutic potential of interleukin-10, J. Exp. Med. 2020 Jan6;217(1);.
2018The Dynamics of Interleukin-10-Afforded Protection during Dextran Sulfate Sodium-Induced Colitis, Front Immunol 2018;9:400.
2017Guidelines for the use of flow cytometry and cell sorting in immunological studies, Eur. J. Immunol. 2017 Oct;47(10):1584-1797.
2017Asynchronous lineage priming determines commitment to T cell and B cell lineages in fetal liver, Nat. Immunol. 2017 18(10):1139-1149.
2017Differential expression of Cathepsin E in transthyretin amyloidosis: from neuropathology to the immune system, J Neuroinflammation 2017 Jun;14(1):115.
2017Essential role of immobilized chemokine CXCL12 in the regulation of the humoral immune response, Proc. Natl. Acad. Sci. U.S.A. 2017 Feb;114(9):2319-2324.
2016Fetal B cell development, In Ratcliffe, M.J.H. (Editor in chief), Encyclopedia of Immunobiology, Vol. 1, pp.46-51 Oxford : Academic Press.
2015Immune quiescence of the brain is set by astroglial connexin 43, J. Neurosci. 2015 Mar;35(10):4427-39.
2014Independent recruitment of Igh alleles in V(D)J recombination, Nat Commun 2014;5:5623.
2014Interleukin-1 signaling pathway as a therapeutic target in transthyretin amyloidosis, Amyloid 2014 Sep;21(3):175-84.
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