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© Institut Pasteur
Macrophages et lymphocytes de souris. Image colorisée.
Publication : The Journal of experimental medicine

Biology and therapeutic potential of interleukin-10

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of experimental medicine - 14 Oct 2019

Saraiva M, Vieira P, O'Garra A

Link to Pubmed [PMID] – 31611251

J. Exp. Med. 2020 Jan6;217(1);

The cytokine IL-10 is a key anti-inflammatory mediator ensuring protection of a host from over-exuberant responses to pathogens and microbiota, while playing important roles in other settings as sterile wound healing, autoimmunity, cancer, and homeostasis. Here we discuss our current understanding of the regulation of IL-10 production and of the molecular pathways associated with IL-10 responses. In addition to IL-10’s classic inhibitory effects on myeloid cells, we also describe the nonclassic roles attributed to this pleiotropic cytokine, including how IL-10 regulates basic processes of neural and adipose cells and how it promotes CD8 T cell activation, as well as epithelial repair. We further discuss its therapeutic potential in the context of different diseases and the outstanding questions that may help develop an effective application of IL-10 in diverse clinical settings.

https://www.ncbi.nlm.nih.gov/pubmed/31611251