Study the neuroinvasiveness of neurotropic Flaviviruses
Flaviviruses such as Japanese encephalitis virus (JEV), West Nile virus (WNV), Yellow Fever virus (YFV) and Zika virus, can infect neuronals cells and cause neuronal damages, when given access to the central nervous system […]
Neural progenitor cell infection by Zika virus in the mouse developing neocortex
Neurotropic flaviviruses are human pathogens responsible for numerous viral encephalitic diseases. West Nile and Japanese encephalitis flaviviruses infect the adult brain and are also responsible for congenital infections that impact fetal brain development. Zika […]
Role of PDZ-binding motif from Flavivirus non-structural proteins in flaviviral life cycle
Arthropod-borne viruses (arboviruses) include numerous human and animal pathogens that are important global health threats. Flaviviruses are arboviruses belonging to the Flaviviridae family. They include neurotropic viruses such as West Nile (WNV), Japanese encephalitis […]
Mutation in Japanese Encephalitis and West Nile virus M protein affects late stages of virus life cycle and pathogenesis.
Flavivirus pre-membrane (prM) protein is important in assembly of viral particles. Its ectodomain is well conserved among flaviviruses. Previous work has shown that expression of this domain can trigger apoptosis in mammalian cells and […]
2017Identifying Attenuating Mutations: Tools for a New Vaccine Design against Flaviviruses, Intervirology 2017;60:8-18.
2016Comparative Analysis Between Flaviviruses Reveals Specific Neural Stem Cell Tropism for Zika Virus in the Mouse Developing Neocortex, EBioMedicine. 2016 Jul 16. pii: S2352-3964(16)30323-1..
2016The E glycoprotein plays an essential role in the high pathogenicity of European-Mediterranean IS98 strain of West Nile virus., Virology. 2016 May;492:53-65. doi: 10.1016/j.virol.2016.02.009. Epub 2016 Feb 19..
2015A Single Amino Acid Substitution in the M Protein Attenuates Japanese Encephalitis Virus in Mammalian Hosts., J Virol. 2015 Dec 9;90(5):2676-89. doi: 10.1128/JVI.01176-15..
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