For project proposals, please submit your project request here on PPMS (stratocore): for the facility use MSBio Core Facilty Request Form : https://ppms.eu/pasteur/req/?pf=29&project=true&form=68. Additionally, you can complete this form and send it to proteomics@pasteur.fr. […]
Every Tuesday mornings from 10am to 12am, Hub engineers are enlisted to provide a direct support to any members of Institut Pasteur seeking help on bioinformatics or biostatistics related subjects. You can come directly […]
Circular dichroism (CD) spectroscopy allows the determination of secondary and tertiary structures, the analysis of conformational changes and the measure of thermal and chemical stability of folding. Differential Scanning Calorimetry (DSC) gives access to […]
Circular dichroism (CD) allows the measurement of secondary and tertiary structures, the analyse of conformational changes, the kinetic of folding and the thermal and chemical stability of folding. Fluorescence spectroscopy gives access to the […]
Analytical Ultracentrifugation gives access to the mass and shape of macromolecules in solution, allowing to evaluate their oligomerization state, their stoichiometry and the equilibrium constant of assemblies. Dynamic Light Scattering (cuvette or microplaque) allows […]
Static Light Scattering allows to measure the mass and intrinsic viscosity of macromolecules Analytical Ultracentrifugation gives access to the oligomerization state and the stoichiometry of molecular assemblies
What we do Phage display technology enables the selection from repertoires of VHH displayed on the surface of filamentous bacteriophage. Llamas or Alpacas are immunized with antigens provided by the users; once the serum […]
X-Ray Diffraction system is composed by : – A RIGAKU micromax 007 X-ray generator with standard rotating anode (wavelength 1.54 Å). – A system of multi-layer X-ray optics from OSMIC. – A mar345dtb […]
Crystal optimization service To refine the conditions of crystallization, the robot Matrixmaker allows to generate solutions of crystallization on various kind of supports (tubes 50 ml, tubes 15 ml, tube Eppendorf 1.5 or 2 […]
Application process of crystallization at 18°C or 4°C In the platform we can setup high-throughput crystallization experiments (18°C or 4°C) with the vapour diffusion (sitting or hanging drop), the microbatch, and the cubic phase […]