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© Pierre Gounon
Entrée de Listeria dans une cellule épithéliale (Grossissement X 10000). Image colorisée.
Publication : Journal of cell science

WASP-related proteins, Abi1 and Ena/VASP are required for Listeria invasion induced by the Met receptor

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of cell science - 15 Mar 2005

Bierne H, Miki H, Innocenti M, Scita G, Gertler FB, Takenawa T, Cossart P

Link to Pubmed [PMID] – 15769844

J. Cell. Sci. 2005 Apr;118(Pt 7):1537-47

Internalisation of the pathogenic bacterium Listeria monocytogenes involves interactions between the invasion protein InlB and the hepatocyte growth factor receptor, Met. Using colocalisation studies, dominant-negative constructs and small interfering RNA (siRNA), we demonstrate a cell-type-dependent requirement for various WASP-related proteins in Listeria entry and InlB-induced membrane ruffling. The WAVE2 isoform is essential for InlB-induced cytoskeletal rearrangements in Vero cells. In HeLa cells, WAVE1, WAVE2 and N-WASP cooperate to promote these processes. Abi1, a key component of WAVE complexes, is recruited at the entry site in both cell types and its inactivation by RNA interference impairs InlB-mediated processes. Ena/VASP proteins also play a role in Listeria internalization, and their deregulation by sequestration or overexpression, modifies actin cups beneath entering particles. Taken together, these results identify the WAVE complex, N-WASP and Ena/VASP as key effectors of the Met signalling pathway and of Listeria entry and highlight the existence of redundant and/or cooperative functions among WASP-family members.

http://www.ncbi.nlm.nih.gov/pubmed/15769844