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© Research
Publication : Journal of the American Society of Nephrology

Transcriptional Changes in Kidney Allografts with Histology of Antibody-Mediated Rejection without Anti-HLA Donor-Specific Antibodies

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of the American Society of Nephrology - 08 Jul 2020

Jasper Callemeyn, Evelyne Lerut, Henriette de Loor, Ingrid Arijs, Olivier Thaunat, Alice Koenig, Vannary Meas-Yedid, Jean-Christophe Olivo-Marin, Philip Halloran, Jessica Chang, Lieven Thorrez, Dirk Kuypers, Ben Sprangers, Leentje Van Lommel, Frans Schuit, Marie Essig, Wilfried Gwinner, Dany Anglicheau, Pierre Marquet and Maarten Naesens

Link to Pubmed [PMID] – 32641395

Link to DOI [DOI] – 10.1681/ASN.2020030306

J Am Soc Nephrol. 2020 Sep;31(9):2168-2183

Donor-specific anti-HLA antibodies (HLA-DSAs) are often not detectable in serum of kidney allograft recipients whose biopsies display histology of antibody-mediated rejection (ABMR), which creates uncertainty in clinical decision making. The authors show that ABMR histology associates with a distinct transcriptional profile that is independent of the presence of HLA-DSAs, although the presence of HLA-DSAs is also an independent risk factor for graft failure after ABMR histology. However, molecular assessment of allograft biopsy specimens does not elucidate the underlying cause of ABMR histology, and these findings indicate that therapeutic decisions should not be based solely on the histologic and molecular presentation. Future studies should work toward identifying and targeting the underlying stimulus of ABMR histology.