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© Pierre Gounon
Entrée de Listeria dans une cellule épithéliale (Grossissement X 10000). Image colorisée.
Publication : Biophysical journal

Transcription within condensed chromatin: Steric hindrance facilitates elongation

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Biophysical journal - 01 Mar 2010

Bécavin C, Barbi M, Victor JM, Lesne A

Link to Pubmed [PMID] – 20197036

Biophys. J. 2010 Mar;98(5):824-33

During eukaryotic transcription, RNA-polymerase activity generates torsional stress in DNA, having a negative impact on the elongation process. Using our previous studies of chromatin fiber structure and conformational transitions, we suggest that this torsional stress can be alleviated, thanks to a tradeoff between the fiber twist and nucleosome conformational transitions into an activated state named “reversome”. Our model enlightens the origin of polymerase pauses, and leads to the counterintuitive conclusion that chromatin-organized compaction might facilitate polymerase progression. Indeed, in a compact and well-structured chromatin loop, steric hindrance between nucleosomes enforces sequential transitions, thus ensuring that the polymerase always meets a permissive nucleosomal state.

http://www.ncbi.nlm.nih.gov/pubmed/20197036