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© Pierre Gounon
Entrée de Listeria dans une cellule épithéliale (Grossissement X 10000). Image colorisée.
Publication : Current opinion in immunology

The use of host cell machinery in the pathogenesis of Listeria monocytogenes

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in immunology - 01 Feb 2001

Cossart P, Bierne H

Link to Pubmed [PMID] – 11154924

Curr. Opin. Immunol. 2001 Feb;13(1):96-103

The bacterial pathogen, Listeria monocytogenes, exploits the host cell’s machinery, enabling the pathogen to enter into cells and spread from cell to cell. Three bacterial surface proteins are crucial for these processes: internalin and InlB, which mediate entry into cells, and ActA, which induces actin polymerisation at one pole of the bacterium and promotes intracellular and intercellular motility. Recent studies have identified several of the cellular factors involved in the entry process and major discoveries have unravelled the mechanisms underlying the actin-based motility. Increasing evidence shows that many cellular genes are up- or down-regulated during infection and probably play a role in the establishment of infection, inflammation and induction of the host immune response.

http://www.ncbi.nlm.nih.gov/pubmed/11154924