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© Research
Publication : The Journal of infectious diseases

Human T cell leukemia virus Type I (HTLV-I) infection induces greater expansions of CD8 T lymphocytes in persons with HTLV-I-associated myelopathy/tropical spastic paraparesis than in asymptomatic carriers

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of infectious diseases - 13 Feb 2001

Ureta-Vidal A, Pique C, Garcia Z, Dehée A, Tortevoye P, Désiré N, Gessain A, Chancerel B, Gout O, Lemonnier FA, Cochet M

Link to Pubmed [PMID] – 11237801

J. Infect. Dis. 2001 Mar;183(6):857-64

A quantitative study of the T cell receptor repertoire was performed ex vivo on CD4 and CD8 T cell subsets of human T cell leukemia virus type I (HTLV-I)-infected asymptomatic carriers and patients with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Indexes of oligoclonality that compiled all repertoire modifications were calculated for peripheral blood mononuclear cells and for CD4 and CD8 T cell subsets. Both patients with HAM/TSP and asymptomatic carriers had greater T lymphocyte expansions than did uninfected donors, which was independent of age and at least twice higher in the CD8 than in the CD4 cell compartment. Some expanded CD8 T cells corresponded to cytotoxic T lymphocytes directed against various epitopes of the immunodominant Tax protein. Patients with HAM/TSP had significantly higher CD8 cell expansions than did asymptomatic carriers. These results highlight the prognostic value of measuring CD8 T cell expansions during follow-up of HTLV-I infection.

https://www.ncbi.nlm.nih.gov/pubmed/11237801