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© Therese Couderc, Marc Lecuit
Publication : Transplant infectious disease : an official journal of the Transplantation Society

Synergistic effect of carbapenem-teicoplanin combination during severe Rhodococcus equi pneumonia in a kidney transplant recipient

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Transplant infectious disease : an official journal of the Transplantation Society - 02 Jun 2009

El Karoui K, Guillet C, Sekkal N, Lanternier F, Méchaï F, Hue K, Hiesse C, Mamzer Bruneel MF, Catherinot E, Viard JP, Mainardi JL, Lecuit M, Ferroni A, Lortholary O

Link to Pubmed [PMID] – 19497046

Transpl Infect Dis 2009 Aug;11(4):359-62

Rhodococcus equi is a bacterial pathogen of domestic animals that can infect immunocompromised patients, especially those with impaired cellular immunity, such as transplant recipients. No standard treatment has been established, but therapy must be prolonged, as relapses are common and can occur at the initial site or distant locations. Here we report a case of R. equi-associated pulmonary abscess in a renal transplant recipient successfully treated with a combination of carbapenem and teicoplanin. This combination was shown to be synergistic. It has minimal side effects in transplant recipients and appears to be an effective initial treatment for this severe infection.

http://www.ncbi.nlm.nih.gov/pubmed/19497046