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© Research
Publication : Journal of fungi (Basel, Switzerland)

The New GPI-Anchored Protein, SwgA, Is Involved in Nitrogen Metabolism in the Pathogenic Filamentous Fungus Aspergillus fumigatus.

Team: Ultrastructural BioImaging
Member: Rémi Beau
Member: Maryse Moya-Nilges
Member: Thierry Fontaine
Member: Jean-Paul Latge
Member: Isabelle Mouyna
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of fungi (Basel, Switzerland) - 15 Feb 2023

Samalova M, Flamant P, Beau R, Bromley M, Moya-Nilges M, Fontaine T, Latgé JP, Mouyna I

Link to Pubmed [PMID] – 36836370

Link to DOI – 10.3390/jof9020256

J Fungi (Basel) 2023 Feb; 9(2):

GPI-anchored proteins display very diverse biological (biochemical and immunological) functions. An in silico analysis has revealed that the genome of Aspergillus fumigatus contains 86 genes coding for putative GPI-anchored proteins (GPI-APs). Past research has demonstrated the involvement of GPI-APs in cell wall remodeling, virulence, and adhesion. We analyzed a new GPI-anchored protein called SwgA. We showed that this protein is mainly present in the Clavati of Aspergillus and is absent from yeasts and other molds. The protein, localized in the membrane of A. fumigatus, is involved in germination, growth, and morphogenesis, and is associated with nitrogen metabolism and thermosensitivity. swgA is controlled by the nitrogen regulator AreA. This current study indicates that GPI-APs have more general functions in fungal metabolism than cell wall biosynthesis.