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© Research
Publication : Trends in microbiology

The Evolution of Protein Secretion Systems by Co-option and Tinkering of Cellular Machineries.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Trends in microbiology - 01 May 2020

Denise R, Abby SS, Rocha EPC,

Link to Pubmed [PMID] – 32298615

Link to DOI [DOI] – S0966-842X(20)30007-X10.1016/j.tim.2020.01.005

Trends Microbiol. 2020 May; 28(5): 372-386

Protein secretion is important for many biotic and abiotic interactions. The evolution of protein secretion systems of bacteria, and related nanomachines, occurred by the co-option of machineries for motility, conjugation, injection, or adhesion. Some of these secretion systems emerged many times, whereas others are unique. In most cases, their evolution occurred by successive rounds of gene accretion, deletion, and horizontal transfer, resulting in machines that can be very different from the original ones. The frequency with which such co-option processes occurred seems to depend on the complexity of the systems, their differences to the ancestral machines, the availability of genetic material to tinker with, and possibly on the mechanisms of effector recognition. Understanding the evolution of secretion systems illuminates their functional diversification and could drive the discovery of novel systems.

https://pubmed.ncbi.nlm.nih.gov/32298615